Kosten-Nutzen-Analyse neuer Lipidsenker View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-04-25

AUTHORS

Christopher Blaum, Natalie Arnold, Christoph Waldeyer

ABSTRACT

Patients with atherosclerotic cardiovascular disease have a high risk for subsequent cardiovascular events despite optimal drug treatment including statins and ezetimibe. Dyslipidemia represents a central and direct cause of this, with a frequent failure to achieve the target values recommended in the guidelines. New lipid-lowering substances are increasingly becoming available for treatment of this residual risk. Due to their high cost, cost-effectiveness analyses are required in order to justify their use. Important variables when considering the cost-effectiveness of a drug are quality adjusted life years (QALY) and the incremental cost-effectiveness ratio (ICER). The lower bounds of the ICER determining the cost-effectiveness of a treatment vary between healthcare systems. The proprotein convertase subtilisin-kexin type 9 (PCSK9) inhibitors alirocumab and evolocumab are deemed to be cost-effective particularly in patients with high levels of low-density lipoprotein cholesterol (LDL-C) prior to treatment or with a high cardiovascular risk as determined by the presence of defined risk criteria. Similar considerations apply to the PCSK9 small interfering RNA (siRNA) inclisiran. Administration of bempedoic acid is deemed cost-effective especially in patients with statin intolerance. Eicosapentaenoic acid is deemed cost-effective overall, although the data with respect to the exact placebo-controlled efficacy are still inconclusive. More... »

PAGES

236-243

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00059-022-05116-8

DOI

http://dx.doi.org/10.1007/s00059-022-05116-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1147364825

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35467096


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