Lipoproteinapherese View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-04-22

AUTHORS

Adrienn Tünnemann-Tarr, Julius Ludwig Katzmann, Joachim Thiery, Ulrich Laufs

ABSTRACT

Lipoprotein apheresis is an extracorporeal procedure for the treatment of patients with homozygous familial hypercholesterolemia, patients with severe treatment-resistant hypercholesterolemia and patients with lipoprotein(a) hypercholesterolemia, who show progressive atherosclerotic cardiovascular disease despite optimal treatment. This article reports on the historical developments of the procedures, the most frequently used methods for apheresis as well as the data situation on efficacy and tolerability. Randomized prospective studies on clinical outcomes are not available. Furthermore, the article reports on a patient with homozygous familial hypercholesterolemia and 34 years of treatment with heparin-induced extracorporeal low-density lipoprotein (LDL) precipitation (HELP) apheresis, the longest treatment of this kind worldwide. A second patient with combined heterozygous familial hypercholesterolemia and 31 years of liposorber and HELP apheresis is also described. The observational studies and the case reports demonstrate the safety and long-term tolerability of the procedure. More... »

PAGES

228-235

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00059-022-05115-9

DOI

http://dx.doi.org/10.1007/s00059-022-05115-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1147317493

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35451597


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