Outcome of a polymer-free drug-coated coronary stent in bifurcation lesions—Pilot registry with serial OCT imaging View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-04-09

AUTHORS

Hendrik Wienemann, Felix Meincke, Marius Vach, Christian-Hendrik Heeger, Annika Meyer, Tobias Spangenberg, Karl Heinz Kuck, Alexander Ghanem

ABSTRACT

BackgroundPolymer-free and carrier-free drug-coated stents (DCS) represent a novel therapeutic option for the treatment of coronary artery disease. The objective of this pilot registry is to evaluate the safety and efficacy of DCS implantation in bifurcation lesions.MethodsOverall, 23 consecutive patients with 24 lesions received a Biolimus A9-coated DCS for coronary bifurcation lesions. Patients were examined with quantitative coronary angiography (QCA) and optical coherence tomography (OCT) at 3–6 months of follow-up.ResultsA total of 23 patients with 24 bifurcation lesions were included in this study. Nine (33.3%) lesions of eight patients revealed angiographical target lesion failure due to in-stent restenosis (ISR). In total, 19 patients with 20 bifurcation lesions were suitable for OCT analysis. A total of 2936 struts were analyzed and 14 struts (0.47%) were classified as malapposed. The mean luminal area (mm2) was not different in lesions with ISR vs. lesions with no ISR (5.07 ± 2.0 vs. 5.73 ± 1.34, p = 0.39) at follow-up. Lesions with ISR showed higher mean neointimal burden (27.11 ± 10.59 vs. 13.93 ± 9.16%, respectively; p = 0.009). All of the patients who presented with significant ISR required percutaneous re-intervention.ConclusionsWe observed a high rate of DCS ISR in bifurcation lesions, possibly related to increased inflammation and neoatherosclerosis. The small size of the study warrants careful interpretation of our results. Larger trials are necessary to expand knowledge of these findings. More... »

PAGES

1-9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00059-022-05109-7

DOI

http://dx.doi.org/10.1007/s00059-022-05109-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1146965238

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35397659


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189 rdf:type schema:Organization
 




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