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    "datePublished": "2018-01-19", 
    "datePublishedReg": "2018-01-19", 
    "description": "BackgroundThe combination drug sacubitril/valsartan was reported to be superior to enalapril in reducing all-cause death, cardiovascular mortality, and heart failure (HF) hospitalizations in patients with cardiac insufficiency and reduced left ventricular ejection fraction (HFREF) with NYHA class\u00a0II\u2013IV.MethodsOur retrospective cohort study aimed to assess the effects of sacubitril/valsartan in addition to a\u00a0beta-blocker and mineral receptor antagonist (MRA) in a\u00a0group of HFREF patients with NYHA class\u00a0II\u2013III HF vs. conventional therapy (ACE inhibitor or angiotensin\u00a0II receptor blocker added to a beta-blocker plus an\u00a0MRA) administered to a\u00a0control group of HFREF patients with comparable clinical features. In both groups, treatment was supplemented by a\u00a0loop diuretic, usually furosemide, at variable doses. The primary outcomes were all-cause death and HF hospitalizations. Safety outcomes were symptomatic hypotension, angioedema, hyperkalemia, and worsening renal function.ResultsMortality at 6\u00a0months was 6.8% in patients taking sacubitril/valsartan vs. 34% in those on conventional therapy (odds ratio [OR]\u00a0= 0.14; 95% CI: 0.04\u20130.49). Moreover, there was a 4.5% rate of HF hospitalizations in the sacubitril/valsartan group vs. 59% in the control group (OR\u00a0= 0.03; 95% CI: 0.01\u20130.14). Safety outcomes were comparable in the two groups, although hypotension (systolic blood pressure <\u202f100\u2009mm\u00a0Hg) was found in 15.9% of patients in the sacubitril/valsartan group vs. 5.7% in the control group (OR\u00a0= 3.14; 95% CI: 0.94\u201310.55).ConclusionSacubitril/valsartan offered strong protection against all-cause death and HF hospitalizations at 6\u00a0months without any significant side effects. To validate this efficacious molecule, further postmarketing observational studies, focusing mainly on hypotension and angioedema are warranted.", 
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        "publisher": "Springer Nature", 
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    "name": "Sacubitril/valsartan for heart failure with reduced left ventricular ejection fraction", 
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