Laboratory Monitoring of Heparin and the Combination of Heparin and the Platelet Glycoprotein IIb/IIIa Receptor Antibody Fragment Abciximab (c7E3) in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-08

AUTHORS

Ralf Zahn, Hannelore Haubelt, Sabine Bechtloff, Steffen Schneider, Birgit Frilling, Jörg Rustige, Parvaneh Marsalek, Karlheinz Seidl, Jochen Senges, Peter Hellstern

ABSTRACT

BACKGROUND: Previous studies in patients undergoing percutaneous transluminal coronary angioplasty (PTCA) have restricted laboratory monitoring to the activated clotting time (ACT). It remains unknown whether the ACT-prolonging effect of abciximab is clinically equivalent to a comparable degree of anti-coagulation by heparin. PATIENTS AND METHODS: 30 patients undergoing PTCA received 100 IU of heparin/kg body weight. Another 30 patients received an initial bolus of 70 IU of heparin/kg + abciximab. We determined ACT, laboratory and onsite activated partial thromboplastin time (APTT) and plasma heparin levels. RESULTS: Despite markedly different preintervention heparin dosing, the ACTs were not significantly different between groups. After termination of PTCA, the median ACTs of both study groups were nearly equivalent (267 vs. 272 s; p = 0.79). The median ACT-prolonging effect of abciximab could be equated with 0.68 IU/ml heparin. Both APTT assays were not suitable for monitoring the anticoagulant effects during PTCA due to their high sensitivity. By contrast, the plasma heparin levels clearly reflected the different heparin doses. The weak correlation (r = 0.23) between ACTs and heparin levels in patients receiving heparin + abciximab was due to excessively prolonged ACTs in six patients (540-1,245 s). These data could be attributed to an unusually high response to abciximab. By contrast, the ACT was a reliable measure of the anticoagulant effect of heparin in patients receiving exclusively heparin. CONCLUSIONS: ACT reflects both heparin and abciximab therapy, whereas heparin levels reflect only heparin dose. The APTT assays were not suitable for monitoring the anticoagulant effects during PTCA. More... »

PAGES

445-452

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00059-003-2349-3

DOI

http://dx.doi.org/10.1007/s00059-003-2349-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016213700

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12928744


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angioplasty, Balloon, Coronary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antibodies, Monoclonal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Anticoagulants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Coagulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Data Interpretation, Statistical", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Therapy, Combination", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrinolytic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heparin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin Fab Fragments", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Partial Thromboplastin Time", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Aggregation Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Glycoprotein GPIIb-IIIa Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sensitivity and Specificity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Whole Blood Coagulation Time", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Leipzig University", 
          "id": "https://www.grid.ac/institutes/grid.9647.c", 
          "name": [
            "Department of Cardiology, Heart Center Ludwigshafen, Germany", 
            "Department of Cardiology, Heart Center, Bremserstra\u00dfe 79, 67063, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zahn", 
        "givenName": "Ralf", 
        "id": "sg:person.01016713172.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016713172.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Hemostaseology and Transfusion Medicine, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haubelt", 
        "givenName": "Hannelore", 
        "id": "sg:person.01200045035.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200045035.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Hemostaseology and Transfusion Medicine, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bechtloff", 
        "givenName": "Sabine", 
        "id": "sg:person.01010632222.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010632222.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiology, Heart Center Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schneider", 
        "givenName": "Steffen", 
        "id": "sg:person.011364136412.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011364136412.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiology, Heart Center Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frilling", 
        "givenName": "Birgit", 
        "id": "sg:person.0760761056.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760761056.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Eli Lilly (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.435900.b", 
          "name": [
            "Lilly Deutschland GmbH, Bad Homburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rustige", 
        "givenName": "J\u00f6rg", 
        "id": "sg:person.01362743075.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362743075.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Eli Lilly (Germany)", 
          "id": "https://www.grid.ac/institutes/grid.435900.b", 
          "name": [
            "Lilly Deutschland GmbH, Bad Homburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Marsalek", 
        "givenName": "Parvaneh", 
        "id": "sg:person.0601446774.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601446774.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiology, Heart Center Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Seidl", 
        "givenName": "Karlheinz", 
        "id": "sg:person.01267010655.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267010655.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Cardiology, Heart Center Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Senges", 
        "givenName": "Jochen", 
        "id": "sg:person.01201414614.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201414614.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute of Hemostaseology and Transfusion Medicine, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hellstern", 
        "givenName": "Peter", 
        "id": "sg:person.0721160742.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721160742.85"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/1053-0770(93)90160-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000162038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0049-3848(90)90075-n", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004049369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(96)00749-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005769124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199706123362401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017752478"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0735-1097(94)90636-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025923389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(99)80616-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038040926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1213/00000539-198404000-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039371992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199404073301402", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040255966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(97)00796-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040303702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5223(96)70191-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053148911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.95.3.614", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063337791"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2003-08", 
    "datePublishedReg": "2003-08-01", 
    "description": "BACKGROUND: Previous studies in patients undergoing percutaneous transluminal coronary angioplasty (PTCA) have restricted laboratory monitoring to the activated clotting time (ACT). It remains unknown whether the ACT-prolonging effect of abciximab is clinically equivalent to a comparable degree of anti-coagulation by heparin.\nPATIENTS AND METHODS: 30 patients undergoing PTCA received 100 IU of heparin/kg body weight. Another 30 patients received an initial bolus of 70 IU of heparin/kg + abciximab. We determined ACT, laboratory and onsite activated partial thromboplastin time (APTT) and plasma heparin levels.\nRESULTS: Despite markedly different preintervention heparin dosing, the ACTs were not significantly different between groups. After termination of PTCA, the median ACTs of both study groups were nearly equivalent (267 vs. 272 s; p = 0.79). The median ACT-prolonging effect of abciximab could be equated with 0.68 IU/ml heparin. Both APTT assays were not suitable for monitoring the anticoagulant effects during PTCA due to their high sensitivity. By contrast, the plasma heparin levels clearly reflected the different heparin doses. The weak correlation (r = 0.23) between ACTs and heparin levels in patients receiving heparin + abciximab was due to excessively prolonged ACTs in six patients (540-1,245 s). These data could be attributed to an unusually high response to abciximab. By contrast, the ACT was a reliable measure of the anticoagulant effect of heparin in patients receiving exclusively heparin.\nCONCLUSIONS: ACT reflects both heparin and abciximab therapy, whereas heparin levels reflect only heparin dose. The APTT assays were not suitable for monitoring the anticoagulant effects during PTCA.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00059-003-2349-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1087175", 
        "issn": [
          "0340-9937", 
          "1615-6692"
        ], 
        "name": "Herz", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Laboratory Monitoring of Heparin and the Combination of Heparin and the Platelet Glycoprotein IIb/IIIa Receptor Antibody Fragment Abciximab (c7E3) in Patients Undergoing Percutaneous Transluminal Coronary Angioplasty (PTCA)", 
    "pagination": "445-452", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "4d412e6a0b02a1ebbd1e07d8178beb770f878ee9e74004d70d5ee6fe519c4f2c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12928744"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7801231"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00059-003-2349-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016213700"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00059-003-2349-3", 
      "https://app.dimensions.ai/details/publication/pub.1016213700"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:53", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000487.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00059-003-2349-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00059-003-2349-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00059-003-2349-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00059-003-2349-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00059-003-2349-3'


 

This table displays all metadata directly associated to this object as RDF triples.

263 TRIPLES      21 PREDICATES      60 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00059-003-2349-3 schema:about N10d9001cf4734e9982786711e03dd322
2 N1618cadde6a843c18660394dca56c4c2
3 N1b0f6dc90be043128693b6334f5d165e
4 N1be45aa8cc5041f18defdb9aa6115263
5 N1c99597af1b74b3789d21f85c6a4d83a
6 N1eecaf4e720e470e91e5c37a27db08d0
7 N3589408a227a4a27af902cba1491e7b0
8 N35e1b4009fe444309e1bfabd3f64544b
9 N3621804acd8e43b487084d79a875400b
10 N37a2c9eeb688490e91a1247af8fde0e7
11 N3cdd12d0de2343a0b71018c0cea05abb
12 N7d8451d86509487e8b797a181321a935
13 N808e60f03b3141acaceb471d59d3d128
14 N883e68109352432c9a0a34ed401e31fb
15 N8901be53726b45a8a6b4a0036c51de43
16 N9d3e42aba1e84b67a332e6c1ab4a91ba
17 Nb131c17385594986bfb1c04c0979fb1b
18 Nb9da4f45d70741a4bf9a1d12a6e6903a
19 Nbac83241a87a4f8c96df2c23e8376c1a
20 Nea37b31cc915483b8573ba1d29526ba2
21 anzsrc-for:11
22 anzsrc-for:1103
23 schema:author N7a701a8fbe7c4196a92190b209adddf0
24 schema:citation https://doi.org/10.1016/0049-3848(90)90075-n
25 https://doi.org/10.1016/0735-1097(94)90636-x
26 https://doi.org/10.1016/1053-0770(93)90160-m
27 https://doi.org/10.1016/s0002-9149(96)00749-7
28 https://doi.org/10.1016/s0002-9149(97)00796-0
29 https://doi.org/10.1016/s0002-9149(99)80616-x
30 https://doi.org/10.1016/s0022-5223(96)70191-5
31 https://doi.org/10.1056/nejm199404073301402
32 https://doi.org/10.1056/nejm199706123362401
33 https://doi.org/10.1161/01.cir.95.3.614
34 https://doi.org/10.1213/00000539-198404000-00003
35 schema:datePublished 2003-08
36 schema:datePublishedReg 2003-08-01
37 schema:description BACKGROUND: Previous studies in patients undergoing percutaneous transluminal coronary angioplasty (PTCA) have restricted laboratory monitoring to the activated clotting time (ACT). It remains unknown whether the ACT-prolonging effect of abciximab is clinically equivalent to a comparable degree of anti-coagulation by heparin. PATIENTS AND METHODS: 30 patients undergoing PTCA received 100 IU of heparin/kg body weight. Another 30 patients received an initial bolus of 70 IU of heparin/kg + abciximab. We determined ACT, laboratory and onsite activated partial thromboplastin time (APTT) and plasma heparin levels. RESULTS: Despite markedly different preintervention heparin dosing, the ACTs were not significantly different between groups. After termination of PTCA, the median ACTs of both study groups were nearly equivalent (267 vs. 272 s; p = 0.79). The median ACT-prolonging effect of abciximab could be equated with 0.68 IU/ml heparin. Both APTT assays were not suitable for monitoring the anticoagulant effects during PTCA due to their high sensitivity. By contrast, the plasma heparin levels clearly reflected the different heparin doses. The weak correlation (r = 0.23) between ACTs and heparin levels in patients receiving heparin + abciximab was due to excessively prolonged ACTs in six patients (540-1,245 s). These data could be attributed to an unusually high response to abciximab. By contrast, the ACT was a reliable measure of the anticoagulant effect of heparin in patients receiving exclusively heparin. CONCLUSIONS: ACT reflects both heparin and abciximab therapy, whereas heparin levels reflect only heparin dose. The APTT assays were not suitable for monitoring the anticoagulant effects during PTCA.
38 schema:genre research_article
39 schema:inLanguage en
40 schema:isAccessibleForFree false
41 schema:isPartOf N687f993a9bf34e5cbd472c11e6b66a37
42 Nfdff32034e2e4d2caf3951e3f40cea6e
43 sg:journal.1087175
44 schema:name Laboratory Monitoring of Heparin and the Combination of Heparin and the Platelet Glycoprotein IIb/IIIa Receptor Antibody Fragment Abciximab (c7E3) in Patients Undergoing Percutaneous Transluminal Coronary Angioplasty (PTCA)
45 schema:pagination 445-452
46 schema:productId N509f477df3a44d79a49c3763fcdca026
47 N58d5dddf8822423dbbb5b1b8ec8d64c9
48 Nd91b25ffc5de443b94e06e6c21142ec2
49 Ne028dce2b6154f0abcaa533a4732e6b2
50 Ne62fdfd9b7b24fca8daa4dda85ce9681
51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016213700
52 https://doi.org/10.1007/s00059-003-2349-3
53 schema:sdDatePublished 2019-04-11T01:53
54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
55 schema:sdPublisher N45f0fcb74ce2494db0245ea16867cd5b
56 schema:url http://link.springer.com/10.1007/s00059-003-2349-3
57 sgo:license sg:explorer/license/
58 sgo:sdDataset articles
59 rdf:type schema:ScholarlyArticle
60 N06c4923d16364329b4b708dfb6318285 schema:name Institute of Hemostaseology and Transfusion Medicine, Ludwigshafen, Germany
61 rdf:type schema:Organization
62 N10d9001cf4734e9982786711e03dd322 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Angioplasty, Balloon, Coronary
64 rdf:type schema:DefinedTerm
65 N1618cadde6a843c18660394dca56c4c2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Antibodies, Monoclonal
67 rdf:type schema:DefinedTerm
68 N1b0f6dc90be043128693b6334f5d165e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Blood Coagulation
70 rdf:type schema:DefinedTerm
71 N1be45aa8cc5041f18defdb9aa6115263 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Whole Blood Coagulation Time
73 rdf:type schema:DefinedTerm
74 N1c99597af1b74b3789d21f85c6a4d83a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Humans
76 rdf:type schema:DefinedTerm
77 N1eecaf4e720e470e91e5c37a27db08d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Anticoagulants
79 rdf:type schema:DefinedTerm
80 N3589408a227a4a27af902cba1491e7b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Fibrinolytic Agents
82 rdf:type schema:DefinedTerm
83 N35e1b4009fe444309e1bfabd3f64544b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Platelet Glycoprotein GPIIb-IIIa Complex
85 rdf:type schema:DefinedTerm
86 N3621804acd8e43b487084d79a875400b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Male
88 rdf:type schema:DefinedTerm
89 N37a2c9eeb688490e91a1247af8fde0e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Drug Therapy, Combination
91 rdf:type schema:DefinedTerm
92 N39ae22e27c9b45bf9959d3be70d4342d schema:name Department of Cardiology, Heart Center Ludwigshafen, Germany
93 rdf:type schema:Organization
94 N3a6acfcae3174e11a5fe98dfd7f986be rdf:first sg:person.01201414614.08
95 rdf:rest Nc3fcc3f12e144d0ab3cda7b8a5bec09f
96 N3affef4be7f74eb3b2fe1b4d753c59d9 schema:name Department of Cardiology, Heart Center Ludwigshafen, Germany
97 rdf:type schema:Organization
98 N3cdd12d0de2343a0b71018c0cea05abb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Platelet Aggregation Inhibitors
100 rdf:type schema:DefinedTerm
101 N3e0d534122a544a4a86e2bf9eab1bacb rdf:first sg:person.01200045035.08
102 rdf:rest N698afe38e71c49a0a6ec6b1feddd6c4d
103 N45f0fcb74ce2494db0245ea16867cd5b schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 N509f477df3a44d79a49c3763fcdca026 schema:name dimensions_id
106 schema:value pub.1016213700
107 rdf:type schema:PropertyValue
108 N55696f1eaa7e4891ada13fb50401c58b rdf:first sg:person.01362743075.80
109 rdf:rest N8d3a55f5e3224a75ad233168590175c8
110 N58d5dddf8822423dbbb5b1b8ec8d64c9 schema:name nlm_unique_id
111 schema:value 7801231
112 rdf:type schema:PropertyValue
113 N687f993a9bf34e5cbd472c11e6b66a37 schema:volumeNumber 28
114 rdf:type schema:PublicationVolume
115 N698afe38e71c49a0a6ec6b1feddd6c4d rdf:first sg:person.01010632222.70
116 rdf:rest Nada8dfcd02834ebdbe101f3aafc37031
117 N7a701a8fbe7c4196a92190b209adddf0 rdf:first sg:person.01016713172.96
118 rdf:rest N3e0d534122a544a4a86e2bf9eab1bacb
119 N7d8451d86509487e8b797a181321a935 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Female
121 rdf:type schema:DefinedTerm
122 N808e60f03b3141acaceb471d59d3d128 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Time Factors
124 rdf:type schema:DefinedTerm
125 N883e68109352432c9a0a34ed401e31fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Middle Aged
127 rdf:type schema:DefinedTerm
128 N8901be53726b45a8a6b4a0036c51de43 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Heparin
130 rdf:type schema:DefinedTerm
131 N8d3a55f5e3224a75ad233168590175c8 rdf:first sg:person.0601446774.54
132 rdf:rest N997eb0a3d5c34056bf7cda30abc87cd5
133 N997eb0a3d5c34056bf7cda30abc87cd5 rdf:first sg:person.01267010655.21
134 rdf:rest N3a6acfcae3174e11a5fe98dfd7f986be
135 N9d3e42aba1e84b67a332e6c1ab4a91ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Sensitivity and Specificity
137 rdf:type schema:DefinedTerm
138 Nada8dfcd02834ebdbe101f3aafc37031 rdf:first sg:person.011364136412.97
139 rdf:rest Nc74a85f29ecc4baa918ed609efcd526c
140 Nb131c17385594986bfb1c04c0979fb1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Aged
142 rdf:type schema:DefinedTerm
143 Nb70efdb8b9a140708aae7d524605abe6 schema:name Institute of Hemostaseology and Transfusion Medicine, Ludwigshafen, Germany
144 rdf:type schema:Organization
145 Nb9b9b129b0e34c9c93518705375cb20b schema:name Department of Cardiology, Heart Center Ludwigshafen, Germany
146 rdf:type schema:Organization
147 Nb9da4f45d70741a4bf9a1d12a6e6903a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Data Interpretation, Statistical
149 rdf:type schema:DefinedTerm
150 Nbac83241a87a4f8c96df2c23e8376c1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Partial Thromboplastin Time
152 rdf:type schema:DefinedTerm
153 Nbbd964e944ef4337a15e89ce5bf38b08 schema:name Institute of Hemostaseology and Transfusion Medicine, Ludwigshafen, Germany
154 rdf:type schema:Organization
155 Nc3fcc3f12e144d0ab3cda7b8a5bec09f rdf:first sg:person.0721160742.85
156 rdf:rest rdf:nil
157 Nc74a85f29ecc4baa918ed609efcd526c rdf:first sg:person.0760761056.27
158 rdf:rest N55696f1eaa7e4891ada13fb50401c58b
159 Nd91b25ffc5de443b94e06e6c21142ec2 schema:name doi
160 schema:value 10.1007/s00059-003-2349-3
161 rdf:type schema:PropertyValue
162 Nd9dd177fe25c4cc0ac93c0c28fbed58c schema:name Department of Cardiology, Heart Center Ludwigshafen, Germany
163 rdf:type schema:Organization
164 Ne028dce2b6154f0abcaa533a4732e6b2 schema:name pubmed_id
165 schema:value 12928744
166 rdf:type schema:PropertyValue
167 Ne62fdfd9b7b24fca8daa4dda85ce9681 schema:name readcube_id
168 schema:value 4d412e6a0b02a1ebbd1e07d8178beb770f878ee9e74004d70d5ee6fe519c4f2c
169 rdf:type schema:PropertyValue
170 Nea37b31cc915483b8573ba1d29526ba2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Immunoglobulin Fab Fragments
172 rdf:type schema:DefinedTerm
173 Nfdff32034e2e4d2caf3951e3f40cea6e schema:issueNumber 5
174 rdf:type schema:PublicationIssue
175 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
176 schema:name Medical and Health Sciences
177 rdf:type schema:DefinedTerm
178 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
179 schema:name Clinical Sciences
180 rdf:type schema:DefinedTerm
181 sg:journal.1087175 schema:issn 0340-9937
182 1615-6692
183 schema:name Herz
184 rdf:type schema:Periodical
185 sg:person.01010632222.70 schema:affiliation Nbbd964e944ef4337a15e89ce5bf38b08
186 schema:familyName Bechtloff
187 schema:givenName Sabine
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01010632222.70
189 rdf:type schema:Person
190 sg:person.01016713172.96 schema:affiliation https://www.grid.ac/institutes/grid.9647.c
191 schema:familyName Zahn
192 schema:givenName Ralf
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016713172.96
194 rdf:type schema:Person
195 sg:person.011364136412.97 schema:affiliation Nb9b9b129b0e34c9c93518705375cb20b
196 schema:familyName Schneider
197 schema:givenName Steffen
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011364136412.97
199 rdf:type schema:Person
200 sg:person.01200045035.08 schema:affiliation Nb70efdb8b9a140708aae7d524605abe6
201 schema:familyName Haubelt
202 schema:givenName Hannelore
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200045035.08
204 rdf:type schema:Person
205 sg:person.01201414614.08 schema:affiliation Nd9dd177fe25c4cc0ac93c0c28fbed58c
206 schema:familyName Senges
207 schema:givenName Jochen
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201414614.08
209 rdf:type schema:Person
210 sg:person.01267010655.21 schema:affiliation N39ae22e27c9b45bf9959d3be70d4342d
211 schema:familyName Seidl
212 schema:givenName Karlheinz
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01267010655.21
214 rdf:type schema:Person
215 sg:person.01362743075.80 schema:affiliation https://www.grid.ac/institutes/grid.435900.b
216 schema:familyName Rustige
217 schema:givenName Jörg
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362743075.80
219 rdf:type schema:Person
220 sg:person.0601446774.54 schema:affiliation https://www.grid.ac/institutes/grid.435900.b
221 schema:familyName Marsalek
222 schema:givenName Parvaneh
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0601446774.54
224 rdf:type schema:Person
225 sg:person.0721160742.85 schema:affiliation N06c4923d16364329b4b708dfb6318285
226 schema:familyName Hellstern
227 schema:givenName Peter
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721160742.85
229 rdf:type schema:Person
230 sg:person.0760761056.27 schema:affiliation N3affef4be7f74eb3b2fe1b4d753c59d9
231 schema:familyName Frilling
232 schema:givenName Birgit
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760761056.27
234 rdf:type schema:Person
235 https://doi.org/10.1016/0049-3848(90)90075-n schema:sameAs https://app.dimensions.ai/details/publication/pub.1004049369
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/0735-1097(94)90636-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025923389
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/1053-0770(93)90160-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1000162038
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0002-9149(96)00749-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005769124
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0002-9149(97)00796-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040303702
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0002-9149(99)80616-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038040926
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0022-5223(96)70191-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053148911
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1056/nejm199404073301402 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040255966
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1056/nejm199706123362401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017752478
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1161/01.cir.95.3.614 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063337791
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1213/00000539-198404000-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039371992
256 rdf:type schema:CreativeWork
257 https://www.grid.ac/institutes/grid.435900.b schema:alternateName Eli Lilly (Germany)
258 schema:name Lilly Deutschland GmbH, Bad Homburg, Germany
259 rdf:type schema:Organization
260 https://www.grid.ac/institutes/grid.9647.c schema:alternateName Leipzig University
261 schema:name Department of Cardiology, Heart Center Ludwigshafen, Germany
262 Department of Cardiology, Heart Center, Bremserstraße 79, 67063, Ludwigshafen, Germany
263 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...