Ontology type: schema:ScholarlyArticle
2013-02
AUTHORSM. Kruschewski, M. Ciurea, S. Lipka, S. Daum, L. Moser, B. Meyer, J. Gröne, J. Budczies, H. J. Buhr
ABSTRACTTrotz standardisierter operativer Techniken und multimodaler Therapiekonzepte treten kolorektale Karzinomrezidive in bis zu 20% der Fälle auf. In der kurativen Therapie dieser Patienten bildet die radikale Resektion den zentralen Bestandteil. Das Ziel dieser Arbeit war es, die Ergebnisse in der Behandlung des lokoregionären Rezidivs des kolorektalen Karzinoms zu evaluieren. Im Zeitraum Januar von 1995 bis Dezember 2007 wurden 82 Patienten wegen eines kolorektalen Karzinomrezidivs operiert, deren Primärtumor R0-reseziert worden war. Neben Patienten-, Tumor- und Therapiecharakteristika wurden das Auftreten von postoperativen Komplikationen sowie die Re-Rezidiv-Freiheit erfasst und das rezidivfreie und das Gesamtüberleben nach der Methode von Kaplan und Meier berechnet. Bei 60 der 82 Patienten (73%) wurde eine Resektion durchgeführt, bei 52% (31/60) gelang eine erneute R0-Resektion. Die postoperative Morbidität lag bei 39% (31/82), die Rate an Relaparotomien bei 13% (11/82) und die Letalität bei 7% (6/82). 48% aller Operierten erhielten ein permanentes Stoma. Ein Re-Rezidiv entwickelten 52% (16/31). Die 5-Jahres-Überlebensrate beträgt bei den R0-resezierten Patienten 35% (11/31). Ausgedehnte Re-Operationen ermöglichen häufig eine erneute R0-Resektion. Trotz relevanter Morbidität erscheint die Letalität vertretbar. Entscheidend für die Prognose ist das Re-Rezidiv. More... »
PAGES6-15
http://scigraph.springernature.com/pub.10.1007/s00053-012-0333-1
DOIhttp://dx.doi.org/10.1007/s00053-012-0333-1
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