Synthesis and antitumor activity of pyrano[3,2-i]-fused camptothecin derivatives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-09

AUTHORS

Bihong Hong, Guangrong Meng, Hanyi Tan, Jiajun Li, Kaimin Kong, Qian Zhang

ABSTRACT

A novel series of A-ring modified hexacyclic camptothecin derivatives containing a pyranone ring fused at the 9-positions and 10-positions were designed and synthesized. These new derivatives were screened against four human tumor cell lines and the results showed most of the compounds possessed comparable cytotoxicity to 10-hydroxycamptothecin (HCPT) in vitro. The pyranono-fused derivatives, except for the one with methoxyformyl group at 4′-position (12), displayed similar inhibitory efficiency to saturated dihydropyrano-fused camptothecins (6 and 7) and superior cytotoxic activity compared with topotecan (TPT). These results indicated that the saturated and unsaturated fused-pyran rings would not disrupt the base-stacking between camptothecins and the DNA base pair, as well as the interactions between the compounds and Topoisomerase I. More... »

PAGES

884-891

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-019-02342-4

DOI

http://dx.doi.org/10.1007/s00044-019-02342-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113330261


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