The modulatory effect of green tea catechin on drug resistance in human ovarian cancer cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-16

AUTHORS

Dawid Przystupski, Olga Michel, Joanna Rossowska, Stanisław Kwiatkowski, Jolanta Saczko, Julita Kulbacka

ABSTRACT

Numerous in vitro and in vivo studies have demonstrated the antiproliferative effect of green tea. It has been speculated that one of its compounds — catechin, may affect multidrug resistance (MDR) phenomena. We examined the effect of catechin and cisplatin on human ovarian cancer cells’ SKOV-3 viability. It was also studied whether preincubation with catechin modulates drug resistance revealed by SKOV-3 cells. Catechin at concentrations up to 200 µM has been shown to be slightly toxic to the tested cells. Analysis of cells after preincubation with catechin revealed increased cytotoxicity of cisplatin compared to the cells treated only with cytostatic and changed expression of MDR-related proteins. Pre-treatment with catechin enhanced cisplatin cytotoxicity by promoting apoptosis and changing activity of membrane proteins involved in drug metabolism, uptake and efflux, especially P-glycoprotein, GST, LRP and BCRP. The obtained results and available reports prove that catechin and its derivatives can potentially be used in chemotherapy as a modulator of MDR phenomena. More... »

PAGES

1-11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-019-02324-6

DOI

http://dx.doi.org/10.1007/s00044-019-02324-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112829503


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00044-019-02324-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00044-019-02324-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00044-019-02324-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00044-019-02324-6'


 

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