Chemical composition, antioxidant, anti-lipooxygenase, antimicrobial, anti-parasite and cytotoxic activities of Polyalthia longifolia seed oil View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-02-22

AUTHORS

O. Atolani, E. T. Areh, O. S. Oguntoye, M. F. Zubair, O. A. Fabiyi, R. A. Oyegoke, D. E Tarigha, N. Adamu, O. S. Adeyemi, L. Kambizi, G. A. Olatunji

ABSTRACT

This work investigates the chemical compositions of Polyalthia longifolia Thw. seed oil with the associated antioxidant, anti-inflammatory, anti-parasite and cytotoxicity potentials. The oil of P. longifolia seed obtained by soxhlet extraction was trans-esterified and the fatty acid profile characterized using gas chromatography mass spectrometry (GC–MS). The antioxidant activity was evaluated using DPPH and ABTS assays. The anti-bacterial and anti-fungi properties of the oil were determine on clinical isolates of the organisms using agar diffusion method. The anti-inflammatory activities, cytotoxicity and anti-parasite potential were evaluated using lipooxygenase, mammalian cell and Toxoplasma gondii assays respectively. P. longifolia seed was observed to contain oleic (30.31%), linoleic acid (19.27%) and palmitic acid (15.11%) as the major fatty acids with low proportion of tricosylic acid (6.10) and stearic acid (5.56%). The oil had significant anti-lipooxygenase activity (IC50 = 0.70 ± 0.02 µg/mL) comparable to indomethacin (IC50 = 0.53 ± 0.07 µg/mL). The DPPH (IC50 = 55.91 ± 31.18 µg/mL) and ABTS (IC50 = 16.89 ± 15.50 µg/mL) antioxidant activity of the oil was lower to the ascorbic acid (IC50 = 0.34 ± 0.04 and 0.54 ± 0.04 µg/mL). The oil also showed activities against all the tested bacteria and fungi. The highest inhibition was recorded against S. aureus (17 ± 1 mm) at concentration 200 mg/mL. Further, the oils showed strong potential to restrict growth of Toxoplasma gondii in vitro, but the parasite growth inhibition was mildly abated in the presence of α-tocopherol. The seed oil of the underutilized P. longifolia possesses essential fatty acids which could be responsible for the numerous biological potentials which include anti-lipooxygenase, antioxidant, anti-inflammatory, anti-parasite, anti-microbial and cytotoxic activities. The incorporation of the natural oil into pharmaceuticals or cosmetics may enhance antioxidant, anti-inflammatory, antimicrobial and cytotoxicity potential of such products. More... »

PAGES

515-527

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-019-02301-z

DOI

http://dx.doi.org/10.1007/s00044-019-02301-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112305073


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