Design, synthesis and anticancer activities of halogenated Phenstatin analogs as microtubule destabilizing agent View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-04

AUTHORS

Shengquan Hu, Wuji Sun, Yeming Wang, Hong Yan

ABSTRACT

A series of halogenated Phenstatin analogs were designed as microtubule destabilizing agent by docking study. It was synthesized within three steps starting from 2-chloro-5-iodobenzoic acid and substituted benzene. All the products were characterized by 1H NMR and 13C NMR spectral analysis, and the stereochemical structure was also confirmed by a single crystal X-ray diffraction crystallographic analysis. The microtubule destabilizing activities were evaluated in vitro with human liver cancer Huh-7 cell line and human lung cancer A549 cell line. Some of the HPAs were achieved IC50 about 5.0 μM against human liver cancer Huh-7 cells. More... »

PAGES

465-472

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-019-02299-4

DOI

http://dx.doi.org/10.1007/s00044-019-02299-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1111912718


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