Total synthesis of the linear and angular 3-methylated regioisomers of the marine natural product Kealiiquinone and biological evaluation of related ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

César R. Solorio-Alvarado, Velayudham Ramadoss, Rocío Gámez-Montaño, Juan R. Zapata-Morales, Angel J. Alonso-Castro

ABSTRACT

A straightforward, concise, and building block-scalable, seven-step total synthesis of the unnatural 3-methylated regioisomer analog of the marine alkaloid kealiiquinone is described. The construction by a regioselective way of the 4-anisyl-3-methylbenzimidazolone core of this analog, as well as the homologation of the aromatic π-system through a 4π ring opening/6π ring closure sequence for the 1,4-quinoid ring construction by using the squaric acid chemistry, are the key features of this procedure. In light that only one total synthesis of this 3-methyl-iso-kealiiquinone has been described by using a Friedel−Crafts reaction as the key step, herein, we present our pericyclic-based strategy which was successfully concluded with the aforementioned alkaloid synthesis. The biological evaluation of these unnatural derivatives was carried out on MDA-MB231 human cancer cell lines of breast. The cis-platin (CDDP) was used as a positive control of activity. More... »

PAGES

473-484

Journal

TITLE

Medicinal Chemistry Research

ISSUE

4

VOLUME

28

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-019-02290-z

DOI

http://dx.doi.org/10.1007/s00044-019-02290-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112025869


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0305", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Organic Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Universidad de Guanajuato", 
          "id": "https://www.grid.ac/institutes/grid.412891.7", 
          "name": [
            "Divisi\u00f3n de Ciencias Naturales y Exactas, Departamento de Qu\u00edmica, Universidad de Guanajuato, Campus Guanajuato, Cerro de la Venada S/N, 36040, Guanajuato, Guanajuato, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Solorio-Alvarado", 
        "givenName": "C\u00e9sar R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad de Guanajuato", 
          "id": "https://www.grid.ac/institutes/grid.412891.7", 
          "name": [
            "Divisi\u00f3n de Ciencias Naturales y Exactas, Departamento de Qu\u00edmica, Universidad de Guanajuato, Campus Guanajuato, Cerro de la Venada S/N, 36040, Guanajuato, Guanajuato, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ramadoss", 
        "givenName": "Velayudham", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad de Guanajuato", 
          "id": "https://www.grid.ac/institutes/grid.412891.7", 
          "name": [
            "Divisi\u00f3n de Ciencias Naturales y Exactas, Departamento de Qu\u00edmica, Universidad de Guanajuato, Campus Guanajuato, Cerro de la Venada S/N, 36040, Guanajuato, Guanajuato, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "G\u00e1mez-Monta\u00f1o", 
        "givenName": "Roc\u00edo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad de Guanajuato", 
          "id": "https://www.grid.ac/institutes/grid.412891.7", 
          "name": [
            "Divisi\u00f3n de Ciencias Naturales y Exactas, Departamento de Farmacia, Universidad de Guanajuato, Campus Guanajuato, Noria Alta S/N, 36050, Guanajuato, Guanajuato, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zapata-Morales", 
        "givenName": "Juan R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universidad de Guanajuato", 
          "id": "https://www.grid.ac/institutes/grid.412891.7", 
          "name": [
            "Divisi\u00f3n de Ciencias Naturales y Exactas, Departamento de Farmacia, Universidad de Guanajuato, Campus Guanajuato, Noria Alta S/N, 36050, Guanajuato, Guanajuato, Mexico"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alonso-Castro", 
        "givenName": "Angel J.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0040-4039(00)96549-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006045966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tips.2010.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008241262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/md202073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014020541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo4027337", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014634123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b007560o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015216405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/np9920900323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015688210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5012/bkcs.2013.34.2.357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018220150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/md201014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018563039"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/md12021066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029486438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1521-3773(19990301)38:5<643::aid-anie643>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040021310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2017.01.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053872168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2017.01.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053872168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2017.01.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053872168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00133a032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055708851"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja020635t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055825576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja020635t", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055825576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja0364118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055833917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja0364118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055833917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja404673s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055854779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja9806128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055869553"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo00033a051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055962252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo00061a011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055964042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo00240a011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055974778"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo00246a017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055975127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo960484a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056035806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo960484a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056035806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/np400538q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056232402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ol100665m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056249901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ol100665m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056249901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ol300704w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056252913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/op060200g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056287687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/op060200g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056287687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3998/ark.5550190.p009.631", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071818596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules22050781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085388439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules22050781", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085388439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.joc.8b01436", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106055343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c8ra06676k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1106464162"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-04", 
    "datePublishedReg": "2019-04-01", 
    "description": "A straightforward, concise, and building block-scalable, seven-step total synthesis of the unnatural 3-methylated regioisomer analog of the marine alkaloid kealiiquinone is described. The construction by a regioselective way of the 4-anisyl-3-methylbenzimidazolone core of this analog, as well as the homologation of the aromatic \u03c0-system through a 4\u03c0 ring opening/6\u03c0 ring closure sequence for the 1,4-quinoid ring construction by using the squaric acid chemistry, are the key features of this procedure. In light that only one total synthesis of this 3-methyl-iso-kealiiquinone has been described by using a Friedel\u2212Crafts reaction as the key step, herein, we present our pericyclic-based strategy which was successfully concluded with the aforementioned alkaloid synthesis. The biological evaluation of these unnatural derivatives was carried out on MDA-MB231 human cancer cell lines of breast. The cis-platin (CDDP) was used as a positive control of activity.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00044-019-02290-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1102690", 
        "issn": [
          "1054-2523", 
          "1554-8120"
        ], 
        "name": "Medicinal Chemistry Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Total synthesis of the linear and angular 3-methylated regioisomers of the marine natural product Kealiiquinone and biological evaluation of related Leucetta sp. alkaloids on human breast cancer", 
    "pagination": "473-484", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f1fcb1af0d59d375637eb02e16fb74275f46399743df9a98797126b945006a78"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00044-019-02290-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112025869"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00044-019-02290-z", 
      "https://app.dimensions.ai/details/publication/pub.1112025869"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78934_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00044-019-02290-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00044-019-02290-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00044-019-02290-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00044-019-02290-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00044-019-02290-z'


 

This table displays all metadata directly associated to this object as RDF triples.

172 TRIPLES      21 PREDICATES      56 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00044-019-02290-z schema:about anzsrc-for:03
2 anzsrc-for:0305
3 schema:author N05190a6fa33b4dd8ac6544a8360e32c5
4 schema:citation https://doi.org/10.1002/(sici)1521-3773(19990301)38:5<643::aid-anie643>3.0.co;2-g
5 https://doi.org/10.1016/j.bmc.2017.01.024
6 https://doi.org/10.1016/j.tips.2010.02.005
7 https://doi.org/10.1016/s0040-4039(00)96549-3
8 https://doi.org/10.1021/acs.joc.8b01436
9 https://doi.org/10.1021/ja00133a032
10 https://doi.org/10.1021/ja020635t
11 https://doi.org/10.1021/ja0364118
12 https://doi.org/10.1021/ja404673s
13 https://doi.org/10.1021/ja9806128
14 https://doi.org/10.1021/jo00033a051
15 https://doi.org/10.1021/jo00061a011
16 https://doi.org/10.1021/jo00240a011
17 https://doi.org/10.1021/jo00246a017
18 https://doi.org/10.1021/jo4027337
19 https://doi.org/10.1021/jo960484a
20 https://doi.org/10.1021/np400538q
21 https://doi.org/10.1021/ol100665m
22 https://doi.org/10.1021/ol300704w
23 https://doi.org/10.1021/op060200g
24 https://doi.org/10.1039/b007560o
25 https://doi.org/10.1039/c8ra06676k
26 https://doi.org/10.1039/np9920900323
27 https://doi.org/10.3390/md12021066
28 https://doi.org/10.3390/md201014
29 https://doi.org/10.3390/md202073
30 https://doi.org/10.3390/molecules22050781
31 https://doi.org/10.3998/ark.5550190.p009.631
32 https://doi.org/10.5012/bkcs.2013.34.2.357
33 schema:datePublished 2019-04
34 schema:datePublishedReg 2019-04-01
35 schema:description A straightforward, concise, and building block-scalable, seven-step total synthesis of the unnatural 3-methylated regioisomer analog of the marine alkaloid kealiiquinone is described. The construction by a regioselective way of the 4-anisyl-3-methylbenzimidazolone core of this analog, as well as the homologation of the aromatic π-system through a 4π ring opening/6π ring closure sequence for the 1,4-quinoid ring construction by using the squaric acid chemistry, are the key features of this procedure. In light that only one total synthesis of this 3-methyl-iso-kealiiquinone has been described by using a Friedel−Crafts reaction as the key step, herein, we present our pericyclic-based strategy which was successfully concluded with the aforementioned alkaloid synthesis. The biological evaluation of these unnatural derivatives was carried out on MDA-MB231 human cancer cell lines of breast. The cis-platin (CDDP) was used as a positive control of activity.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N009ee9327980499a87969236fb8d5621
40 N7880a9d8281c49feb7d0a87af6092c37
41 sg:journal.1102690
42 schema:name Total synthesis of the linear and angular 3-methylated regioisomers of the marine natural product Kealiiquinone and biological evaluation of related Leucetta sp. alkaloids on human breast cancer
43 schema:pagination 473-484
44 schema:productId N6a862e645f2d44a7adb253e116ea900d
45 Nd73c53d8607c4259bee033f5747d72be
46 Ne9038d7a64e3414eb06625c9796c9cac
47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112025869
48 https://doi.org/10.1007/s00044-019-02290-z
49 schema:sdDatePublished 2019-04-11T13:17
50 schema:sdLicense https://scigraph.springernature.com/explorer/license/
51 schema:sdPublisher Ncef8fe8826014fb78b0d87c3cc9f1b64
52 schema:url https://link.springer.com/10.1007%2Fs00044-019-02290-z
53 sgo:license sg:explorer/license/
54 sgo:sdDataset articles
55 rdf:type schema:ScholarlyArticle
56 N009ee9327980499a87969236fb8d5621 schema:issueNumber 4
57 rdf:type schema:PublicationIssue
58 N02d3f7efcbbf4b3d99f330e0ed7fa57c schema:affiliation https://www.grid.ac/institutes/grid.412891.7
59 schema:familyName Alonso-Castro
60 schema:givenName Angel J.
61 rdf:type schema:Person
62 N05190a6fa33b4dd8ac6544a8360e32c5 rdf:first Nca8dabc286324b55a47bf1b0248c0290
63 rdf:rest N5064cd1d72a942648a6ed0e9fac7225f
64 N0d11bfa9cde64edf8f5f064db7962633 rdf:first N02d3f7efcbbf4b3d99f330e0ed7fa57c
65 rdf:rest rdf:nil
66 N4556d25ac23942968383a344be32f178 schema:affiliation https://www.grid.ac/institutes/grid.412891.7
67 schema:familyName Zapata-Morales
68 schema:givenName Juan R.
69 rdf:type schema:Person
70 N5064cd1d72a942648a6ed0e9fac7225f rdf:first Ndc4596b17000433a8e7831bb2a831f02
71 rdf:rest N8ca95de50e334d72b38c239f473b8360
72 N51185c9a47854acdaf64f3ed1d9edb36 schema:affiliation https://www.grid.ac/institutes/grid.412891.7
73 schema:familyName Gámez-Montaño
74 schema:givenName Rocío
75 rdf:type schema:Person
76 N6a862e645f2d44a7adb253e116ea900d schema:name dimensions_id
77 schema:value pub.1112025869
78 rdf:type schema:PropertyValue
79 N75b0383975f14f7386f52e76ad7955ff rdf:first N4556d25ac23942968383a344be32f178
80 rdf:rest N0d11bfa9cde64edf8f5f064db7962633
81 N7880a9d8281c49feb7d0a87af6092c37 schema:volumeNumber 28
82 rdf:type schema:PublicationVolume
83 N8ca95de50e334d72b38c239f473b8360 rdf:first N51185c9a47854acdaf64f3ed1d9edb36
84 rdf:rest N75b0383975f14f7386f52e76ad7955ff
85 Nca8dabc286324b55a47bf1b0248c0290 schema:affiliation https://www.grid.ac/institutes/grid.412891.7
86 schema:familyName Solorio-Alvarado
87 schema:givenName César R.
88 rdf:type schema:Person
89 Ncef8fe8826014fb78b0d87c3cc9f1b64 schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 Nd73c53d8607c4259bee033f5747d72be schema:name doi
92 schema:value 10.1007/s00044-019-02290-z
93 rdf:type schema:PropertyValue
94 Ndc4596b17000433a8e7831bb2a831f02 schema:affiliation https://www.grid.ac/institutes/grid.412891.7
95 schema:familyName Ramadoss
96 schema:givenName Velayudham
97 rdf:type schema:Person
98 Ne9038d7a64e3414eb06625c9796c9cac schema:name readcube_id
99 schema:value f1fcb1af0d59d375637eb02e16fb74275f46399743df9a98797126b945006a78
100 rdf:type schema:PropertyValue
101 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
102 schema:name Chemical Sciences
103 rdf:type schema:DefinedTerm
104 anzsrc-for:0305 schema:inDefinedTermSet anzsrc-for:
105 schema:name Organic Chemistry
106 rdf:type schema:DefinedTerm
107 sg:journal.1102690 schema:issn 1054-2523
108 1554-8120
109 schema:name Medicinal Chemistry Research
110 rdf:type schema:Periodical
111 https://doi.org/10.1002/(sici)1521-3773(19990301)38:5<643::aid-anie643>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1040021310
112 rdf:type schema:CreativeWork
113 https://doi.org/10.1016/j.bmc.2017.01.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053872168
114 rdf:type schema:CreativeWork
115 https://doi.org/10.1016/j.tips.2010.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008241262
116 rdf:type schema:CreativeWork
117 https://doi.org/10.1016/s0040-4039(00)96549-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006045966
118 rdf:type schema:CreativeWork
119 https://doi.org/10.1021/acs.joc.8b01436 schema:sameAs https://app.dimensions.ai/details/publication/pub.1106055343
120 rdf:type schema:CreativeWork
121 https://doi.org/10.1021/ja00133a032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055708851
122 rdf:type schema:CreativeWork
123 https://doi.org/10.1021/ja020635t schema:sameAs https://app.dimensions.ai/details/publication/pub.1055825576
124 rdf:type schema:CreativeWork
125 https://doi.org/10.1021/ja0364118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055833917
126 rdf:type schema:CreativeWork
127 https://doi.org/10.1021/ja404673s schema:sameAs https://app.dimensions.ai/details/publication/pub.1055854779
128 rdf:type schema:CreativeWork
129 https://doi.org/10.1021/ja9806128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055869553
130 rdf:type schema:CreativeWork
131 https://doi.org/10.1021/jo00033a051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055962252
132 rdf:type schema:CreativeWork
133 https://doi.org/10.1021/jo00061a011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055964042
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1021/jo00240a011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055974778
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1021/jo00246a017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055975127
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1021/jo4027337 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014634123
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1021/jo960484a schema:sameAs https://app.dimensions.ai/details/publication/pub.1056035806
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1021/np400538q schema:sameAs https://app.dimensions.ai/details/publication/pub.1056232402
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1021/ol100665m schema:sameAs https://app.dimensions.ai/details/publication/pub.1056249901
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1021/ol300704w schema:sameAs https://app.dimensions.ai/details/publication/pub.1056252913
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1021/op060200g schema:sameAs https://app.dimensions.ai/details/publication/pub.1056287687
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1039/b007560o schema:sameAs https://app.dimensions.ai/details/publication/pub.1015216405
152 rdf:type schema:CreativeWork
153 https://doi.org/10.1039/c8ra06676k schema:sameAs https://app.dimensions.ai/details/publication/pub.1106464162
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1039/np9920900323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015688210
156 rdf:type schema:CreativeWork
157 https://doi.org/10.3390/md12021066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029486438
158 rdf:type schema:CreativeWork
159 https://doi.org/10.3390/md201014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018563039
160 rdf:type schema:CreativeWork
161 https://doi.org/10.3390/md202073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014020541
162 rdf:type schema:CreativeWork
163 https://doi.org/10.3390/molecules22050781 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085388439
164 rdf:type schema:CreativeWork
165 https://doi.org/10.3998/ark.5550190.p009.631 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071818596
166 rdf:type schema:CreativeWork
167 https://doi.org/10.5012/bkcs.2013.34.2.357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018220150
168 rdf:type schema:CreativeWork
169 https://www.grid.ac/institutes/grid.412891.7 schema:alternateName Universidad de Guanajuato
170 schema:name División de Ciencias Naturales y Exactas, Departamento de Farmacia, Universidad de Guanajuato, Campus Guanajuato, Noria Alta S/N, 36050, Guanajuato, Guanajuato, Mexico
171 División de Ciencias Naturales y Exactas, Departamento de Química, Universidad de Guanajuato, Campus Guanajuato, Cerro de la Venada S/N, 36040, Guanajuato, Guanajuato, Mexico
172 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...