Synthesis of NSAIDs–Se derivatives as potent anticancer agents View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

lei Liu, Shaolei Li, Xiaolong Li, Min Zhong, Yin Lu, Yang Jiajie, Zhang Yongmin, Xianran He

ABSTRACT

In the present study, a series of NSAIDs–Se derivatives include selenocyanates and diselenides were synthesized and characterized, their anticancer activities against the human cancer cell lines SW480, HeLa, A549, and HepG2 were determined. Interestingly, most of the new compounds showed active in reducing the viability of different cancer lines. Compounds 1a and 1m exhibited higher promising activities than other derivatives. As the most active compound 1a showed IC50 values lower than 20 μM against the four cancer cell lines, particularly against SW480 with IC50 values below 10 μm, it shows the potential to be a promising molecular chemotherapeutic agent for colorectal cancer. More... »

PAGES

2071-2078

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-018-2216-7

DOI

http://dx.doi.org/10.1007/s00044-018-2216-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105556406


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