Bis-(5-substituted-2-thiono-1,3,5-thiadiazinan-3-yl) butane as a scaffold of anti-proliferative activity, blended by a multicomponent process View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01-30

AUTHORS

Abdel-Nasser El-Shorbagi, Mohamed El-Naggar, Hamadeh Tarazi, Sachin Chaudhary, Hajjaj Abdu-Allah, Fatema Hersi, Hany Omar

ABSTRACT

In the search for promising anti-proliferative agents that might be helpful in the treatment of cancer effectively, several compounds in a series (4b–j) comprising 1,4-bis (5-substituted -2-thiono-2H-tetrahydro-1,3,5-thiadiazin-3-yl) butane derivatives have been isolated. The aimed two privileged thiadiazinane pharmacophores were symmetrically assembled in one molecular frame via 1,4-diaminobutane; the endogenous compound produced by the breakdown of some amino acids that’s known as putrescine. The thiadiazinane rings bearing variable substituents at N-5 as well. The structure of the new derivatives, which were obtained by domino-reactions in water are confirmed by NMR and ESI-MS spectra. Data of 1H-NMR and 13C-NMR. NMR-spectra revealed symmetrical structural features. The anti-proliferative activity was evaluated against five different human cancer cell lines. Compounds 4b, 4d, 4e, and 4j (IC50 range 0.11–0.24 µM), were found potent against Hep3B (hepatocellular carcinoma). Compounds 4d and 4e are also potent (IC50 = 0.42 and 0.41 µM) against U-87 MG (Brain (glioblastoma astrocytoma)). Moreover, 4d provided (IC50 = 0.53 µM) against HepG2 (hepatocellular carcinoma), (A549 (lung carcinoma), and HT-29 (human colorectal adenocarcinoma), as well as normal cell line (fibroblast F180). All the derivatives 4b, 4d, 4e, and 4j are not only more potent, but also relatively safer than doxorubicin in the cell-lines mentioned. The anti-proliferative profile indicates that these compounds are good leads as anti-cancer agents and merit further studies to optimize their structure, detect their bio-targets and in vivo activity.New butane-bis-thiadiazinanes 4e, 4d, 4j, and 4b were found potent against Hep3B (hepatocellular carcinoma) providing (IC50 of 0.11, 0.21, 0.21, and 0.24 µM, respectively) and of high safety index (SI), compared to doxorubicin. More... »

PAGES

1103-1110

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-018-2133-9

DOI

http://dx.doi.org/10.1007/s00044-018-2133-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100718022


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Sharjah Institute for Medical Research, University of Sharjah, 27272, Sharjah, UAE", 
          "id": "http://www.grid.ac/institutes/grid.412789.1", 
          "name": [
            "College of Pharmacy, University of Sharjah, 27272, Sharjah, UAE", 
            "Sharjah Institute for Medical Research, University of Sharjah, 27272, Sharjah, UAE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "El-Shorbagi", 
        "givenName": "Abdel-Nasser", 
        "id": "sg:person.01264737617.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264737617.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Sciences, University of Sharjah, 27272, Sharjah, UAE", 
          "id": "http://www.grid.ac/institutes/grid.412789.1", 
          "name": [
            "College of Sciences, University of Sharjah, 27272, Sharjah, UAE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "El-Naggar", 
        "givenName": "Mohamed", 
        "id": "sg:person.010761030456.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010761030456.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sharjah Institute for Medical Research, University of Sharjah, 27272, Sharjah, UAE", 
          "id": "http://www.grid.ac/institutes/grid.412789.1", 
          "name": [
            "College of Pharmacy, University of Sharjah, 27272, Sharjah, UAE", 
            "Sharjah Institute for Medical Research, University of Sharjah, 27272, Sharjah, UAE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tarazi", 
        "givenName": "Hamadeh", 
        "id": "sg:person.014306363665.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014306363665.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "College of Pharmacy, University of Sharjah, 27272, Sharjah, UAE", 
          "id": "http://www.grid.ac/institutes/grid.412789.1", 
          "name": [
            "College of Pharmacy, University of Sharjah, 27272, Sharjah, UAE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chaudhary", 
        "givenName": "Sachin", 
        "id": "sg:person.014100735651.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014100735651.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Assiut, 71526, Assiut, Egypt", 
          "id": "http://www.grid.ac/institutes/grid.252487.e", 
          "name": [
            "Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Assiut, 71526, Assiut, Egypt"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Abdu-Allah", 
        "givenName": "Hajjaj", 
        "id": "sg:person.01363750761.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363750761.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sharjah Institute for Medical Research, University of Sharjah, 27272, Sharjah, UAE", 
          "id": "http://www.grid.ac/institutes/grid.412789.1", 
          "name": [
            "Sharjah Institute for Medical Research, University of Sharjah, 27272, Sharjah, UAE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hersi", 
        "givenName": "Fatema", 
        "id": "sg:person.01000204165.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000204165.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sharjah Institute for Medical Research, University of Sharjah, 27272, Sharjah, UAE", 
          "id": "http://www.grid.ac/institutes/grid.412789.1", 
          "name": [
            "College of Pharmacy, University of Sharjah, 27272, Sharjah, UAE", 
            "Sharjah Institute for Medical Research, University of Sharjah, 27272, Sharjah, UAE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Omar", 
        "givenName": "Hany", 
        "id": "sg:person.01306554275.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306554275.06"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf00944183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027828778", 
          "https://doi.org/10.1007/bf00944183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc3599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026519625", 
          "https://doi.org/10.1038/nrc3599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/j.pharep.2015.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024014115", 
          "https://doi.org/10.1016/j.pharep.2015.09.007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00204-002-0329-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008644601", 
          "https://doi.org/10.1007/s00204-002-0329-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12272-010-2222-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006056494", 
          "https://doi.org/10.1007/s12272-010-2222-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-01-30", 
    "datePublishedReg": "2018-01-30", 
    "description": "In the search for promising anti-proliferative agents that might be helpful in the treatment of cancer effectively, several compounds in a series (4b\u2013j) comprising 1,4-bis (5-substituted -2-thiono-2H-tetrahydro-1,3,5-thiadiazin-3-yl) butane derivatives have been isolated. The aimed two privileged thiadiazinane pharmacophores were symmetrically assembled in one molecular frame via 1,4-diaminobutane; the endogenous compound produced by the breakdown of some amino acids that\u2019s known as putrescine. The thiadiazinane rings bearing variable substituents at N-5 as well. The structure of the new derivatives, which were obtained by domino-reactions in water are confirmed by NMR and ESI-MS spectra. Data of 1H-NMR and 13C-NMR. NMR-spectra revealed symmetrical structural features. The anti-proliferative activity was evaluated against five different human cancer cell lines. Compounds 4b, 4d, 4e, and 4j (IC50 range 0.11\u20130.24\u2009\u00b5M), were found potent against Hep3B (hepatocellular carcinoma). Compounds 4d and 4e are also potent (IC50\u2009=\u20090.42 and 0.41\u2009\u00b5M) against U-87 MG (Brain (glioblastoma astrocytoma)). Moreover, 4d provided (IC50\u2009=\u20090.53\u2009\u00b5M) against HepG2 (hepatocellular carcinoma), (A549 (lung carcinoma), and HT-29 (human colorectal adenocarcinoma), as well as normal cell line (fibroblast F180). All the derivatives 4b, 4d, 4e, and 4j are not only more potent, but also relatively safer than doxorubicin in the cell-lines mentioned. The anti-proliferative profile indicates that these compounds are good leads as anti-cancer agents and merit further studies to optimize their structure, detect their bio-targets and in vivo activity.New butane-bis-thiadiazinanes 4e, 4d, 4j, and 4b were found potent against Hep3B (hepatocellular carcinoma) providing (IC50 of 0.11, 0.21, 0.21, and 0.24 \u00b5M, respectively) and of high safety index (SI), compared to doxorubicin.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00044-018-2133-9", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1102690", 
        "issn": [
          "1054-2523", 
          "1554-8120"
        ], 
        "name": "Medicinal Chemistry Research", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "27"
      }
    ], 
    "keywords": [
      "cancer cell lines", 
      "anti-proliferative agents", 
      "treatment of cancer", 
      "ESI-MS spectra", 
      "different human cancer cell lines", 
      "human cancer cell lines", 
      "anti-proliferative activity", 
      "U-87 MG", 
      "NMR-spectra", 
      "cell lines", 
      "endogenous compounds", 
      "molecular frame", 
      "butane derivatives", 
      "compound 4b", 
      "new derivatives", 
      "variable substituent", 
      "compound 4d", 
      "cancer", 
      "structural features", 
      "compounds", 
      "treatment", 
      "derivatives", 
      "Hep3B", 
      "amino acids", 
      "NMR", 
      "HepG2", 
      "agents", 
      "substituents", 
      "pharmacophore", 
      "activity", 
      "putrescine", 
      "spectra", 
      "water", 
      "N-5", 
      "acid", 
      "search", 
      "structure", 
      "data", 
      "lines", 
      "Mg", 
      "features", 
      "series", 
      "breakdown", 
      "frame", 
      "privileged thiadiazinane pharmacophores", 
      "thiadiazinane pharmacophores", 
      "thiadiazinane", 
      "symmetrical structural features"
    ], 
    "name": "Bis-(5-substituted-2-thiono-1,3,5-thiadiazinan-3-yl) butane as a scaffold of anti-proliferative activity, blended by a multicomponent process", 
    "pagination": "1103-1110", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1100718022"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00044-018-2133-9"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00044-018-2133-9", 
      "https://app.dimensions.ai/details/publication/pub.1100718022"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_785.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00044-018-2133-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00044-018-2133-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00044-018-2133-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00044-018-2133-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00044-018-2133-9'


 

This table displays all metadata directly associated to this object as RDF triples.

175 TRIPLES      22 PREDICATES      78 URIs      65 LITERALS      6 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00044-018-2133-9 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N8f7a164ace6c4184a0564572ab268eb8
4 schema:citation sg:pub.10.1007/bf00944183
5 sg:pub.10.1007/s00204-002-0329-7
6 sg:pub.10.1007/s12272-010-2222-x
7 sg:pub.10.1016/j.pharep.2015.09.007
8 sg:pub.10.1038/nrc3599
9 schema:datePublished 2018-01-30
10 schema:datePublishedReg 2018-01-30
11 schema:description In the search for promising anti-proliferative agents that might be helpful in the treatment of cancer effectively, several compounds in a series (4b–j) comprising 1,4-bis (5-substituted -2-thiono-2H-tetrahydro-1,3,5-thiadiazin-3-yl) butane derivatives have been isolated. The aimed two privileged thiadiazinane pharmacophores were symmetrically assembled in one molecular frame via 1,4-diaminobutane; the endogenous compound produced by the breakdown of some amino acids that’s known as putrescine. The thiadiazinane rings bearing variable substituents at N-5 as well. The structure of the new derivatives, which were obtained by domino-reactions in water are confirmed by NMR and ESI-MS spectra. Data of 1H-NMR and 13C-NMR. NMR-spectra revealed symmetrical structural features. The anti-proliferative activity was evaluated against five different human cancer cell lines. Compounds 4b, 4d, 4e, and 4j (IC50 range 0.11–0.24 µM), were found potent against Hep3B (hepatocellular carcinoma). Compounds 4d and 4e are also potent (IC50 = 0.42 and 0.41 µM) against U-87 MG (Brain (glioblastoma astrocytoma)). Moreover, 4d provided (IC50 = 0.53 µM) against HepG2 (hepatocellular carcinoma), (A549 (lung carcinoma), and HT-29 (human colorectal adenocarcinoma), as well as normal cell line (fibroblast F180). All the derivatives 4b, 4d, 4e, and 4j are not only more potent, but also relatively safer than doxorubicin in the cell-lines mentioned. The anti-proliferative profile indicates that these compounds are good leads as anti-cancer agents and merit further studies to optimize their structure, detect their bio-targets and in vivo activity.New butane-bis-thiadiazinanes 4e, 4d, 4j, and 4b were found potent against Hep3B (hepatocellular carcinoma) providing (IC50 of 0.11, 0.21, 0.21, and 0.24 µM, respectively) and of high safety index (SI), compared to doxorubicin.
12 schema:genre article
13 schema:inLanguage en
14 schema:isAccessibleForFree false
15 schema:isPartOf Nd7441cac551d43358f2c75f3160f82e5
16 Ndbafbd8a67c7406fbe791044d016eddc
17 sg:journal.1102690
18 schema:keywords ESI-MS spectra
19 Hep3B
20 HepG2
21 Mg
22 N-5
23 NMR
24 NMR-spectra
25 U-87 MG
26 acid
27 activity
28 agents
29 amino acids
30 anti-proliferative activity
31 anti-proliferative agents
32 breakdown
33 butane derivatives
34 cancer
35 cancer cell lines
36 cell lines
37 compound 4b
38 compound 4d
39 compounds
40 data
41 derivatives
42 different human cancer cell lines
43 endogenous compounds
44 features
45 frame
46 human cancer cell lines
47 lines
48 molecular frame
49 new derivatives
50 pharmacophore
51 privileged thiadiazinane pharmacophores
52 putrescine
53 search
54 series
55 spectra
56 structural features
57 structure
58 substituents
59 symmetrical structural features
60 thiadiazinane
61 thiadiazinane pharmacophores
62 treatment
63 treatment of cancer
64 variable substituent
65 water
66 schema:name Bis-(5-substituted-2-thiono-1,3,5-thiadiazinan-3-yl) butane as a scaffold of anti-proliferative activity, blended by a multicomponent process
67 schema:pagination 1103-1110
68 schema:productId N0ae930babc894d22bc114d601ead8f1a
69 Na67100811328422289d7ac108ccb131c
70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100718022
71 https://doi.org/10.1007/s00044-018-2133-9
72 schema:sdDatePublished 2022-01-01T18:49
73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
74 schema:sdPublisher N171b813045ce41498b39f0cecc9f7392
75 schema:url https://doi.org/10.1007/s00044-018-2133-9
76 sgo:license sg:explorer/license/
77 sgo:sdDataset articles
78 rdf:type schema:ScholarlyArticle
79 N0ae930babc894d22bc114d601ead8f1a schema:name dimensions_id
80 schema:value pub.1100718022
81 rdf:type schema:PropertyValue
82 N171b813045ce41498b39f0cecc9f7392 schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N3c23c396d55a455b8690ee7317feef64 rdf:first sg:person.014306363665.45
85 rdf:rest Nb1290afea6cc4d1991650a230384dcee
86 N53a388d87dd4402e9c3d7b3f57ca22a9 rdf:first sg:person.01306554275.06
87 rdf:rest rdf:nil
88 N56e78f9123494aa39617d9b83f4e7c76 rdf:first sg:person.01000204165.06
89 rdf:rest N53a388d87dd4402e9c3d7b3f57ca22a9
90 N871bf6d6feb74182a69df80d3ae2876d rdf:first sg:person.01363750761.54
91 rdf:rest N56e78f9123494aa39617d9b83f4e7c76
92 N89c7bb6a1ab441129c5033b2a387cb7a rdf:first sg:person.010761030456.41
93 rdf:rest N3c23c396d55a455b8690ee7317feef64
94 N8f7a164ace6c4184a0564572ab268eb8 rdf:first sg:person.01264737617.87
95 rdf:rest N89c7bb6a1ab441129c5033b2a387cb7a
96 Na67100811328422289d7ac108ccb131c schema:name doi
97 schema:value 10.1007/s00044-018-2133-9
98 rdf:type schema:PropertyValue
99 Nb1290afea6cc4d1991650a230384dcee rdf:first sg:person.014100735651.37
100 rdf:rest N871bf6d6feb74182a69df80d3ae2876d
101 Nd7441cac551d43358f2c75f3160f82e5 schema:issueNumber 4
102 rdf:type schema:PublicationIssue
103 Ndbafbd8a67c7406fbe791044d016eddc schema:volumeNumber 27
104 rdf:type schema:PublicationVolume
105 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
106 schema:name Medical and Health Sciences
107 rdf:type schema:DefinedTerm
108 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
109 schema:name Oncology and Carcinogenesis
110 rdf:type schema:DefinedTerm
111 sg:journal.1102690 schema:issn 1054-2523
112 1554-8120
113 schema:name Medicinal Chemistry Research
114 schema:publisher Springer Nature
115 rdf:type schema:Periodical
116 sg:person.01000204165.06 schema:affiliation grid-institutes:grid.412789.1
117 schema:familyName Hersi
118 schema:givenName Fatema
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000204165.06
120 rdf:type schema:Person
121 sg:person.010761030456.41 schema:affiliation grid-institutes:grid.412789.1
122 schema:familyName El-Naggar
123 schema:givenName Mohamed
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010761030456.41
125 rdf:type schema:Person
126 sg:person.01264737617.87 schema:affiliation grid-institutes:grid.412789.1
127 schema:familyName El-Shorbagi
128 schema:givenName Abdel-Nasser
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01264737617.87
130 rdf:type schema:Person
131 sg:person.01306554275.06 schema:affiliation grid-institutes:grid.412789.1
132 schema:familyName Omar
133 schema:givenName Hany
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306554275.06
135 rdf:type schema:Person
136 sg:person.01363750761.54 schema:affiliation grid-institutes:grid.252487.e
137 schema:familyName Abdu-Allah
138 schema:givenName Hajjaj
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363750761.54
140 rdf:type schema:Person
141 sg:person.014100735651.37 schema:affiliation grid-institutes:grid.412789.1
142 schema:familyName Chaudhary
143 schema:givenName Sachin
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014100735651.37
145 rdf:type schema:Person
146 sg:person.014306363665.45 schema:affiliation grid-institutes:grid.412789.1
147 schema:familyName Tarazi
148 schema:givenName Hamadeh
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014306363665.45
150 rdf:type schema:Person
151 sg:pub.10.1007/bf00944183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027828778
152 https://doi.org/10.1007/bf00944183
153 rdf:type schema:CreativeWork
154 sg:pub.10.1007/s00204-002-0329-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008644601
155 https://doi.org/10.1007/s00204-002-0329-7
156 rdf:type schema:CreativeWork
157 sg:pub.10.1007/s12272-010-2222-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006056494
158 https://doi.org/10.1007/s12272-010-2222-x
159 rdf:type schema:CreativeWork
160 sg:pub.10.1016/j.pharep.2015.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024014115
161 https://doi.org/10.1016/j.pharep.2015.09.007
162 rdf:type schema:CreativeWork
163 sg:pub.10.1038/nrc3599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026519625
164 https://doi.org/10.1038/nrc3599
165 rdf:type schema:CreativeWork
166 grid-institutes:grid.252487.e schema:alternateName Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Assiut, 71526, Assiut, Egypt
167 schema:name Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, University of Assiut, 71526, Assiut, Egypt
168 rdf:type schema:Organization
169 grid-institutes:grid.412789.1 schema:alternateName College of Pharmacy, University of Sharjah, 27272, Sharjah, UAE
170 College of Sciences, University of Sharjah, 27272, Sharjah, UAE
171 Sharjah Institute for Medical Research, University of Sharjah, 27272, Sharjah, UAE
172 schema:name College of Pharmacy, University of Sharjah, 27272, Sharjah, UAE
173 College of Sciences, University of Sharjah, 27272, Sharjah, UAE
174 Sharjah Institute for Medical Research, University of Sharjah, 27272, Sharjah, UAE
175 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...