In vitro anticholinesterase activity and molecular docking studies of coumarin derivatives isolated from roots of Heptaptera cilicica View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-09-22

AUTHORS

Hilal Özbek, Zühal Güvenalp, Gülderen Yılmaz, Kadir Ö. Yerdelen, Cavit Kazaz, Ömür L. Demirezer

ABSTRACT

The chloroform extract of the roots of Heptaptera cilicica (Boiss. & Bal.) Tutin (Apiaceae) was investigated in terms of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory effects by Ellman method. Afterwards, a new furocoumarin: trichoclin angelate with five known coumarin derivatives: umbelliprenin, badrakemone, badrakemin, badrakemin acetate and prunate were isolated from this extract. Their structures were identified by means of spectroscopic methods (1D, 2D-NMR and HRESIMS). The next step of our study was determining AChE and BuChE inhibitory activities of the compounds by molecular docking and in vitro methods. According to the results, prunate was found to be the most potent compound, which exhibited significant inhibitory potency against acetylcholinesterase (IC50 = 1.76 ± 0.003 µM) and butyrylcholinesterase (IC50 = 0.21 ± 0.002 μM) as compared with the reference compound, galantamine hydrobromide. More... »

PAGES

538-545

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-017-2080-x

DOI

http://dx.doi.org/10.1007/s00044-017-2080-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091896800


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