An efficient synthesis of indolo[2,3-b]quinoline guanidine derivatives with their in vitro and in vivo study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-12

AUTHORS

Katarzyna Sidoryk, Marta Świtalska, Piotr Rózga, Joanna Wietrzyk, Iwona Bujak, Bartłomiej Żerek, Łukasz Kaczmarek, Marcin Cybulski

ABSTRACT

An optimization of the guanidylation process by verifying the efficacy of common guanylation reagents in order to obtain the guanidine derivatives of indolo[2,3-b]quinoline has been performed. As a result, a high-yield procedure using N,N'-di-Boc-N''-triflylguanidine was applied to synthesize the guanidine derivative of indolo[2,3-b]quinoline 1 in a gram scale for specific in vitro and in vivo biological research. Extensive studies on the antiproliferative activity against eight human tumor cell lines were completed. Compound 1 revealed the highest activity against A549 lung adenocarcinoma and MCF7 breast cancer cell lines. Thus, 1 was evaluated for the in vivo anticancer activity against 4T1 mammary gland carcinoma and KLN205 murine lung carcinoma in mouse models. The anticancer effect was observed in the KLN205 model with a 37% tumor growth inhibition at the 20 mg/kg dose. This anticancer activity of 1 was comparable to that of cyclophosphamide which inhibited murine lung tumor growth in the range of 27-43% at the dose of 100 mg/kg. The biochemistry research after 1 admission, including measurements of blood parameters like alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and urea and creatinine, were also performed. More... »

PAGES

3354-3366

References to SciGraph publications

  • 2015-12. Drug sensitivity in cancer cell lines is not tissue-specific in MOLECULAR CANCER
  • 2001-12. The Guanidinium Group in Molecular Recognition: Design and Synthetic Approaches in JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00044-017-2028-1

    DOI

    http://dx.doi.org/10.1007/s00044-017-2028-1

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29170613


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