Synthesis, spectroscopic characterization, X-ray structure, and in vivo neurotropic activity of new 1,5-benzodiazepin-2-ones View Full Text


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Article Info

DATE

2016-09

AUTHORS

Alexandr A. Gaponov, Elena T. Zlenko, Svetlana V. Shishkina, Oleg V. Shishkin, Oleksii M. Antypenko, Serhii V. Tretiakov, Vitaliy A. Palchikov

ABSTRACT

The paper reports the synthesis and in vivo pharmacological studies of a series of N-alkyl-1,5-benzodiazepine-2-ones. In this work, 19 novel benzodiazepine derivatives have been prepared and characterized by spectroscopic methods including 2D nuclear magnetic resonance techniques. Crystal structure of 1-benzyl-8-methyl-4-phenyl-1H-benzo[b][1,4]diazepin-2(3H)-one has also been determined by X-ray diffraction. Prediction of activity spectra for substances prediction and docking studies onto human serum albumin were conducted. Two compounds under these investigation showed high antihypoxic, tranquilizing, and anticonvulsant activity in vivo. More... »

PAGES

1768-1780

References to SciGraph publications

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  • 1982-04. Antileptazol activity and kinetic of CP 1414 S (7-nitro-2-amino-5-phenyl-3-H-, 1,5-benzodiazepine-4-one) in the rat and mouse in EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
  • 2011-06. Five-membered oxaza heterocyclic compounds on the basis of epoxides and aziridines in RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
  • 2013-06. Morpholines. Synthesis and biological activity in RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
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