Synthesis and potential anticonvulsant activity of new aryl sulfonyl semicarbazide derivatives View Full Text


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Article Info

DATE

2016-07

AUTHORS

Yousong Nie, Min Zhong, Zhiyuan Jiang, Jian Sun, Yangguang Gao, Fei Ding, Hang Li, Yongmin Zhang, Xianran He

ABSTRACT

In the present study on the development of new anticonvulsants, twelve new aryl sulfonyl semicarbazide derivatives were synthesized and tested for anticonvulsant activity using maximal electroshock (MES), subcutaneous pentylenetetrazole screens. Their neurotoxicity was determined by the rotorod test. The most active compound 5i showed the MES-induced seizures with ED50 value of 7.3 mg/kg and TD50 value of 402.3 mg/kg after intraperitoneally injection to mice, which provided compound 5i with a protective index (TD50/ED50) of 55.1 in the MES test. More... »

PAGES

1425-1432

References to SciGraph publications

  • 2015-12. Synthesis and potential anticonvulsant activity of new 5,5-cyclopropanespirohydantoin derivatives in MEDICINAL CHEMISTRY RESEARCH
  • 2007-01. Discovery of antiepileptic drugs in NEUROTHERAPEUTICS
  • 2005-04. Zonisamide in CNS DRUGS
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    http://scigraph.springernature.com/pub.10.1007/s00044-016-1582-2

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    http://dx.doi.org/10.1007/s00044-016-1582-2

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