Anticancer activity and DNA binding property of the dimers of triphenylethylene–coumarin hybrid with two amino side chains View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

Mo Zhu, Likai Zhou, Yuchao Yao, Shuai Li, Mengjiao Lv, Kerang Wang, Xiaoliu Li, Hua Chen

ABSTRACT

Novel dimers of triphenylethylene–coumarin hybrid containing two amino side chains were designed and synthesized by the condensation of three dicarboxylic acids with the amino monomeric hybrids catalyzed by HATU and DIPEA at room temperature. All the dimeric compounds exhibited significant anti-proliferative activity against four cancer cells at IC50 of near 10 μM, and higher than their corresponding monomeric compounds except compound 9b. Among them, compounds 9a (R = NEt2) linked by sebacamide and 8b (R = piperidinyl) linked by adipamide were the best ones, respectively. UV–Vis, fluorescence, and circular dichroism (CD) spectroscopies and thermal denaturation exhibited that the monomeric compounds 6b and the dimers 7b, 8b, and 9b had significant interactions with Ct-DNA by the intercalative mode of binding. The order of their anti-proliferative activities was 8b > 7b> 6b > 9b, in accordance with that of their DNA binding properties. Novel dimers of triphenylethylene–coumarin hybrid containing two amino side chains were designed and synthesized. All the dimeric compounds exhibited significant anti-proliferative activity against cancer cells. Both the length of the linker and the basic amino group had certain effects on their anti-proliferative activity. Anticancer activity and DNA binding property of the dimers of triphenylethylene–coumarin hybrid with two amino side chains More... »

PAGES

2314-2324

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-014-1296-2

DOI

http://dx.doi.org/10.1007/s00044-014-1296-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020372114


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hebei University", 
          "id": "https://www.grid.ac/institutes/grid.256885.4", 
          "name": [
            "Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, 071002, Baoding, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhu", 
        "givenName": "Mo", 
        "id": "sg:person.01274713036.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274713036.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hebei University", 
          "id": "https://www.grid.ac/institutes/grid.256885.4", 
          "name": [
            "Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, 071002, Baoding, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Likai", 
        "id": "sg:person.0746504163.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746504163.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hebei University", 
          "id": "https://www.grid.ac/institutes/grid.256885.4", 
          "name": [
            "Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, 071002, Baoding, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yao", 
        "givenName": "Yuchao", 
        "id": "sg:person.01074263146.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074263146.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hebei University", 
          "id": "https://www.grid.ac/institutes/grid.256885.4", 
          "name": [
            "Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, 071002, Baoding, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Shuai", 
        "id": "sg:person.01142376346.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142376346.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hebei University", 
          "id": "https://www.grid.ac/institutes/grid.256885.4", 
          "name": [
            "Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, 071002, Baoding, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lv", 
        "givenName": "Mengjiao", 
        "id": "sg:person.01210511546.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210511546.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hebei University", 
          "id": "https://www.grid.ac/institutes/grid.256885.4", 
          "name": [
            "Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, 071002, Baoding, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Kerang", 
        "id": "sg:person.01257714377.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257714377.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hebei University", 
          "id": "https://www.grid.ac/institutes/grid.256885.4", 
          "name": [
            "Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, 071002, Baoding, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xiaoliu", 
        "id": "sg:person.01324740146.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324740146.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hebei University", 
          "id": "https://www.grid.ac/institutes/grid.256885.4", 
          "name": [
            "Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, 071002, Baoding, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Hua", 
        "id": "sg:person.01245367727.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245367727.37"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ejmech.2013.12.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004360932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejmech.2014.02.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006013655"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2004.04.081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008222306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c1pp05106g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013788056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bioorg.2013.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015946927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2010.03.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018037634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3835(02)00031-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018621614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2013.09.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025283764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2013.12.084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027124872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(01)00859-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027746984"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bpc.2005.03.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030363612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2013.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031733841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejmech.2014.01.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035896483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ardp.201000218", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036045151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1211/jpp.59.5.0013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036114953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2013.12.095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038280996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ica.2003.07.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041911547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2008.06.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043304331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2014.04.106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045584457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2008.01.050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046533239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2010.08.017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047621781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2011.02.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047709258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-4838(99)00251-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050116249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2006.06.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050565368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.poly.2009.10.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051890210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmcl.2010.10.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051927202"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(83)90303-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053705634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(83)90303-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053705634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr200325f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054024890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00279a016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055168419"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja00707a062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055741474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm040025z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055948569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm040025z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055948569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm100757r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055951781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm100757r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055951781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm101120u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055951929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm101120u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055951929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm101337v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm101337v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200148p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200148p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952207"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200553w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200553w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952370"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200983e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm200983e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055952538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm300922h", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055953220"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm301899y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055953599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm400025g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055953616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm400045y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055953626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm400408r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055953769"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm4005175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055953815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm400546y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055953828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm5008648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055954817"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp070378k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056070518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp070378k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056070518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp102937y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056076638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp102937y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056076638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la991719r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056172100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la991719r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056172100"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ma000081j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056172558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ma000081j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056172558"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ol061918j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056248395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ol061918j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056248395"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076595658", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-06", 
    "datePublishedReg": "2015-06-01", 
    "description": "Novel dimers of triphenylethylene\u2013coumarin hybrid containing two amino side chains were designed and synthesized by the condensation of three dicarboxylic acids with the amino monomeric hybrids catalyzed by HATU and DIPEA at room temperature. All the dimeric compounds exhibited significant anti-proliferative activity against four cancer cells at IC50 of near 10 \u03bcM, and higher than their corresponding monomeric compounds except compound 9b. Among them, compounds 9a (R = NEt2) linked by sebacamide and 8b (R = piperidinyl) linked by adipamide were the best ones, respectively. UV\u2013Vis, fluorescence, and circular dichroism (CD) spectroscopies and thermal denaturation exhibited that the monomeric compounds 6b and the dimers 7b, 8b, and 9b had significant interactions with Ct-DNA by the intercalative mode of binding. The order of their anti-proliferative activities was 8b > 7b> 6b > 9b, in accordance with that of their DNA binding properties. Novel dimers of triphenylethylene\u2013coumarin hybrid containing two amino side chains were designed and synthesized. All the dimeric compounds exhibited significant anti-proliferative activity against cancer cells. Both the length of the linker and the basic amino group had certain effects on their anti-proliferative activity. Anticancer activity and DNA binding property of the dimers of triphenylethylene\u2013coumarin hybrid with two amino side chains", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00044-014-1296-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4966580", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1102690", 
        "issn": [
          "1054-2523", 
          "1554-8120"
        ], 
        "name": "Medicinal Chemistry Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "Anticancer activity and DNA binding property of the dimers of triphenylethylene\u2013coumarin hybrid with two amino side chains", 
    "pagination": "2314-2324", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "61114100123370fd3e8b786793a23e32f583c7179e6f1bdcea267360236e4e3a"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00044-014-1296-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1020372114"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00044-014-1296-2", 
      "https://app.dimensions.ai/details/publication/pub.1020372114"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:49", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000504.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00044-014-1296-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00044-014-1296-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00044-014-1296-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00044-014-1296-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00044-014-1296-2'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      21 PREDICATES      78 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00044-014-1296-2 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N800240e700fb419fb2fe8c574b9c35c1
4 schema:citation https://app.dimensions.ai/details/publication/pub.1076595658
5 https://doi.org/10.1002/ardp.201000218
6 https://doi.org/10.1016/0022-1759(83)90303-4
7 https://doi.org/10.1016/j.bioorg.2013.11.002
8 https://doi.org/10.1016/j.bmc.2006.06.029
9 https://doi.org/10.1016/j.bmc.2010.03.069
10 https://doi.org/10.1016/j.bmcl.2004.04.081
11 https://doi.org/10.1016/j.bmcl.2008.01.050
12 https://doi.org/10.1016/j.bmcl.2008.06.013
13 https://doi.org/10.1016/j.bmcl.2010.08.017
14 https://doi.org/10.1016/j.bmcl.2010.10.116
15 https://doi.org/10.1016/j.bmcl.2011.02.016
16 https://doi.org/10.1016/j.bmcl.2013.07.009
17 https://doi.org/10.1016/j.bmcl.2013.09.035
18 https://doi.org/10.1016/j.bmcl.2013.12.084
19 https://doi.org/10.1016/j.bmcl.2013.12.095
20 https://doi.org/10.1016/j.bmcl.2014.04.106
21 https://doi.org/10.1016/j.bpc.2005.03.015
22 https://doi.org/10.1016/j.ejmech.2013.12.061
23 https://doi.org/10.1016/j.ejmech.2014.01.050
24 https://doi.org/10.1016/j.ejmech.2014.02.026
25 https://doi.org/10.1016/j.ica.2003.07.010
26 https://doi.org/10.1016/j.poly.2009.10.031
27 https://doi.org/10.1016/s0014-2999(01)00859-7
28 https://doi.org/10.1016/s0167-4838(99)00251-4
29 https://doi.org/10.1016/s0304-3835(02)00031-9
30 https://doi.org/10.1021/bi00279a016
31 https://doi.org/10.1021/cr200325f
32 https://doi.org/10.1021/ja00707a062
33 https://doi.org/10.1021/jm040025z
34 https://doi.org/10.1021/jm100757r
35 https://doi.org/10.1021/jm101120u
36 https://doi.org/10.1021/jm101337v
37 https://doi.org/10.1021/jm200148p
38 https://doi.org/10.1021/jm200553w
39 https://doi.org/10.1021/jm200983e
40 https://doi.org/10.1021/jm300922h
41 https://doi.org/10.1021/jm301899y
42 https://doi.org/10.1021/jm400025g
43 https://doi.org/10.1021/jm400045y
44 https://doi.org/10.1021/jm400408r
45 https://doi.org/10.1021/jm4005175
46 https://doi.org/10.1021/jm400546y
47 https://doi.org/10.1021/jm5008648
48 https://doi.org/10.1021/jp070378k
49 https://doi.org/10.1021/jp102937y
50 https://doi.org/10.1021/la991719r
51 https://doi.org/10.1021/ma000081j
52 https://doi.org/10.1021/ol061918j
53 https://doi.org/10.1039/c1pp05106g
54 https://doi.org/10.1211/jpp.59.5.0013
55 schema:datePublished 2015-06
56 schema:datePublishedReg 2015-06-01
57 schema:description Novel dimers of triphenylethylene–coumarin hybrid containing two amino side chains were designed and synthesized by the condensation of three dicarboxylic acids with the amino monomeric hybrids catalyzed by HATU and DIPEA at room temperature. All the dimeric compounds exhibited significant anti-proliferative activity against four cancer cells at IC50 of near 10 μM, and higher than their corresponding monomeric compounds except compound 9b. Among them, compounds 9a (R = NEt2) linked by sebacamide and 8b (R = piperidinyl) linked by adipamide were the best ones, respectively. UV–Vis, fluorescence, and circular dichroism (CD) spectroscopies and thermal denaturation exhibited that the monomeric compounds 6b and the dimers 7b, 8b, and 9b had significant interactions with Ct-DNA by the intercalative mode of binding. The order of their anti-proliferative activities was 8b > 7b> 6b > 9b, in accordance with that of their DNA binding properties. Novel dimers of triphenylethylene–coumarin hybrid containing two amino side chains were designed and synthesized. All the dimeric compounds exhibited significant anti-proliferative activity against cancer cells. Both the length of the linker and the basic amino group had certain effects on their anti-proliferative activity. Anticancer activity and DNA binding property of the dimers of triphenylethylene–coumarin hybrid with two amino side chains
58 schema:genre research_article
59 schema:inLanguage en
60 schema:isAccessibleForFree false
61 schema:isPartOf N9333a50674a44a5ab5b40778c8bb0213
62 Nbdf98b82f71c44abab50f86e50df294e
63 sg:journal.1102690
64 schema:name Anticancer activity and DNA binding property of the dimers of triphenylethylene–coumarin hybrid with two amino side chains
65 schema:pagination 2314-2324
66 schema:productId N5f2fd89cb88048a58a5e6c1daad75c90
67 Ne515c2597d4f4a4da1de74f28e4a7f3e
68 Nf965041654924702b84446e08733a238
69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020372114
70 https://doi.org/10.1007/s00044-014-1296-2
71 schema:sdDatePublished 2019-04-10T15:49
72 schema:sdLicense https://scigraph.springernature.com/explorer/license/
73 schema:sdPublisher N55eca1930b394f96be1b992aaf9a7e67
74 schema:url http://link.springer.com/10.1007%2Fs00044-014-1296-2
75 sgo:license sg:explorer/license/
76 sgo:sdDataset articles
77 rdf:type schema:ScholarlyArticle
78 N3b101a071efa465ba475211db4814532 rdf:first sg:person.01142376346.04
79 rdf:rest N94c85d0ea0b74c0fb71d6ae86d86c4fc
80 N3f0c1aeeeb674aa38f410d2baed6ad73 rdf:first sg:person.01245367727.37
81 rdf:rest rdf:nil
82 N4591fcd2c57245dc97c3c7e303549add rdf:first sg:person.01324740146.31
83 rdf:rest N3f0c1aeeeb674aa38f410d2baed6ad73
84 N4ba71089aa5044049458d3bc41fddc50 rdf:first sg:person.0746504163.17
85 rdf:rest N8892264c79e8494bbdc6f8671d532613
86 N55eca1930b394f96be1b992aaf9a7e67 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N5f2fd89cb88048a58a5e6c1daad75c90 schema:name readcube_id
89 schema:value 61114100123370fd3e8b786793a23e32f583c7179e6f1bdcea267360236e4e3a
90 rdf:type schema:PropertyValue
91 N800240e700fb419fb2fe8c574b9c35c1 rdf:first sg:person.01274713036.48
92 rdf:rest N4ba71089aa5044049458d3bc41fddc50
93 N83bf38c6fea2421096354b351919b554 rdf:first sg:person.01257714377.83
94 rdf:rest N4591fcd2c57245dc97c3c7e303549add
95 N8892264c79e8494bbdc6f8671d532613 rdf:first sg:person.01074263146.05
96 rdf:rest N3b101a071efa465ba475211db4814532
97 N9333a50674a44a5ab5b40778c8bb0213 schema:issueNumber 6
98 rdf:type schema:PublicationIssue
99 N94c85d0ea0b74c0fb71d6ae86d86c4fc rdf:first sg:person.01210511546.04
100 rdf:rest N83bf38c6fea2421096354b351919b554
101 Nbdf98b82f71c44abab50f86e50df294e schema:volumeNumber 24
102 rdf:type schema:PublicationVolume
103 Ne515c2597d4f4a4da1de74f28e4a7f3e schema:name dimensions_id
104 schema:value pub.1020372114
105 rdf:type schema:PropertyValue
106 Nf965041654924702b84446e08733a238 schema:name doi
107 schema:value 10.1007/s00044-014-1296-2
108 rdf:type schema:PropertyValue
109 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
110 schema:name Biological Sciences
111 rdf:type schema:DefinedTerm
112 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
113 schema:name Biochemistry and Cell Biology
114 rdf:type schema:DefinedTerm
115 sg:grant.4966580 http://pending.schema.org/fundedItem sg:pub.10.1007/s00044-014-1296-2
116 rdf:type schema:MonetaryGrant
117 sg:journal.1102690 schema:issn 1054-2523
118 1554-8120
119 schema:name Medicinal Chemistry Research
120 rdf:type schema:Periodical
121 sg:person.01074263146.05 schema:affiliation https://www.grid.ac/institutes/grid.256885.4
122 schema:familyName Yao
123 schema:givenName Yuchao
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074263146.05
125 rdf:type schema:Person
126 sg:person.01142376346.04 schema:affiliation https://www.grid.ac/institutes/grid.256885.4
127 schema:familyName Li
128 schema:givenName Shuai
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142376346.04
130 rdf:type schema:Person
131 sg:person.01210511546.04 schema:affiliation https://www.grid.ac/institutes/grid.256885.4
132 schema:familyName Lv
133 schema:givenName Mengjiao
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01210511546.04
135 rdf:type schema:Person
136 sg:person.01245367727.37 schema:affiliation https://www.grid.ac/institutes/grid.256885.4
137 schema:familyName Chen
138 schema:givenName Hua
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245367727.37
140 rdf:type schema:Person
141 sg:person.01257714377.83 schema:affiliation https://www.grid.ac/institutes/grid.256885.4
142 schema:familyName Wang
143 schema:givenName Kerang
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257714377.83
145 rdf:type schema:Person
146 sg:person.01274713036.48 schema:affiliation https://www.grid.ac/institutes/grid.256885.4
147 schema:familyName Zhu
148 schema:givenName Mo
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274713036.48
150 rdf:type schema:Person
151 sg:person.01324740146.31 schema:affiliation https://www.grid.ac/institutes/grid.256885.4
152 schema:familyName Li
153 schema:givenName Xiaoliu
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324740146.31
155 rdf:type schema:Person
156 sg:person.0746504163.17 schema:affiliation https://www.grid.ac/institutes/grid.256885.4
157 schema:familyName Zhou
158 schema:givenName Likai
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0746504163.17
160 rdf:type schema:Person
161 https://app.dimensions.ai/details/publication/pub.1076595658 schema:CreativeWork
162 https://doi.org/10.1002/ardp.201000218 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036045151
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/0022-1759(83)90303-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053705634
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.bioorg.2013.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015946927
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.bmc.2006.06.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050565368
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.bmc.2010.03.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018037634
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.bmcl.2004.04.081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008222306
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/j.bmcl.2008.01.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046533239
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1016/j.bmcl.2008.06.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043304331
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1016/j.bmcl.2010.08.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047621781
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1016/j.bmcl.2010.10.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051927202
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1016/j.bmcl.2011.02.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047709258
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/j.bmcl.2013.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031733841
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.bmcl.2013.09.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025283764
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.bmcl.2013.12.084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027124872
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.bmcl.2013.12.095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038280996
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.bmcl.2014.04.106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045584457
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.bpc.2005.03.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030363612
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.ejmech.2013.12.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004360932
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.ejmech.2014.01.050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035896483
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.ejmech.2014.02.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006013655
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.ica.2003.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041911547
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.poly.2009.10.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051890210
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/s0014-2999(01)00859-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027746984
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/s0167-4838(99)00251-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050116249
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/s0304-3835(02)00031-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018621614
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1021/bi00279a016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055168419
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1021/cr200325f schema:sameAs https://app.dimensions.ai/details/publication/pub.1054024890
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1021/ja00707a062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055741474
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1021/jm040025z schema:sameAs https://app.dimensions.ai/details/publication/pub.1055948569
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1021/jm100757r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055951781
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1021/jm101120u schema:sameAs https://app.dimensions.ai/details/publication/pub.1055951929
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1021/jm101337v schema:sameAs https://app.dimensions.ai/details/publication/pub.1055952022
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1021/jm200148p schema:sameAs https://app.dimensions.ai/details/publication/pub.1055952207
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1021/jm200553w schema:sameAs https://app.dimensions.ai/details/publication/pub.1055952370
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1021/jm200983e schema:sameAs https://app.dimensions.ai/details/publication/pub.1055952538
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1021/jm300922h schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953220
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1021/jm301899y schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953599
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1021/jm400025g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953616
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1021/jm400045y schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953626
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1021/jm400408r schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953769
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1021/jm4005175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953815
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1021/jm400546y schema:sameAs https://app.dimensions.ai/details/publication/pub.1055953828
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1021/jm5008648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055954817
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1021/jp070378k schema:sameAs https://app.dimensions.ai/details/publication/pub.1056070518
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1021/jp102937y schema:sameAs https://app.dimensions.ai/details/publication/pub.1056076638
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1021/la991719r schema:sameAs https://app.dimensions.ai/details/publication/pub.1056172100
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1021/ma000081j schema:sameAs https://app.dimensions.ai/details/publication/pub.1056172558
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1021/ol061918j schema:sameAs https://app.dimensions.ai/details/publication/pub.1056248395
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1039/c1pp05106g schema:sameAs https://app.dimensions.ai/details/publication/pub.1013788056
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1211/jpp.59.5.0013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036114953
261 rdf:type schema:CreativeWork
262 https://www.grid.ac/institutes/grid.256885.4 schema:alternateName Hebei University
263 schema:name Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, 071002, Baoding, China
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...