A potential anticancer agent 1,2-di(quinazolin-4-yl)diselane induces apoptosis in non-small-cell lung cancer A549 cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-05

AUTHORS

Yinjiu Huang, Xiaomei Hu, Gang Liu, Hao Liu, Jianguo Hu, Zhenzhong Feng, Bi Tang, Jun Qian, Qiyi Wang, Yuyuan Zhang, Yanan Pu

ABSTRACT

Lung cancer is presently the most commonly diagnosed metastatic tumor and the leading cause of cancer-related deaths worldwide. Moreover, drug resistance occurs frequently in lung cancer patients. There is an urgent need for developing promising anticancer drugs to improve overall survival of patients with lung cancer. In our recent antitumor drug discovery study, 1,2-di(quinazolin-4-yl)diselane (LG003) exhibited broad spectrum antitumor effects, and demonstrated such effect on A549 cells through physiological pathways rather than cytotoxicity. This suggests that compound LG003 is a potential antitumor agent. In the present study, treatment time and dosage tests indicated LG003 inhibited A549 cells in time- and dosage-dependent manner. Morphological observation did show that compound LG003 treatment resulted in inhibition of cell proliferation and morphological changes in time- and dosage-dependent manner. Subsequent cell cycle analysis revealed that LG003-induced G1-phase arrest followed by accumulation in hypodiploid population phase in cell cycle progression. The typical apoptosis-like morphological changes were also observed in synchronous observation of A549 cells. AO/EB staining and DNA ladder assay confirmed LG003-induced nuclear condensation and characteristic apoptotic DNA ladder in A549 cells. Annexin V-FITC apoptosis analysis indicated that LG003 treatment for 48 h induced the apoptosis of A549 cells in a dosage-dependent manner. Based on these results, we concluded that LG003 executed antitumor activity mainly through inhibiting cell proliferation in the early stage of treatment, then inducing apoptotic death which implied that LG003 should be a potential antitumor candidate worthing more extensive study to be developed as anticancer agents against Lung cancer. More... »

PAGES

2085-2096

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-014-1283-7

DOI

http://dx.doi.org/10.1007/s00044-014-1283-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002923167


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Bioscience, Bengbu Medical College, 233030, Bengbu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Yinjiu", 
        "id": "sg:person.014555453641.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014555453641.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Bioscience, Bengbu Medical College, 233030, Bengbu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Xiaomei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ludong University", 
          "id": "https://www.grid.ac/institutes/grid.443651.1", 
          "name": [
            "School of Chemistry and Materials Science, Ludong University, 264025, Yantai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Gang", 
        "id": "sg:person.07674254222.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07674254222.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Faculty of Pharmacy, Bengbu Medical College, 233030, Bengbu, Anhui, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Hao", 
        "id": "sg:person.01212142420.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212142420.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Scientific Research Center, Bengbu Medical College, 233030, Bengbu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Jianguo", 
        "id": "sg:person.014237122137.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014237122137.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Pathology, Bengbu Medical College, 233030, Bengbu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Feng", 
        "givenName": "Zhenzhong", 
        "id": "sg:person.01200601705.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200601705.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Affiliated Hospital of Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.414884.5", 
          "name": [
            "The First Affiliated Hospital of Bengbu Medical College, 233030, Bengbu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "Bi", 
        "id": "sg:person.014457467742.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014457467742.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "First Affiliated Hospital of Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.414884.5", 
          "name": [
            "The First Affiliated Hospital of Bengbu Medical College, 233030, Bengbu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qian", 
        "givenName": "Jun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Scientific Research Center, Bengbu Medical College, 233030, Bengbu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Qiyi", 
        "id": "sg:person.01363533155.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363533155.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Bioscience, Bengbu Medical College, 233030, Bengbu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yuyuan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Bengbu Medical College", 
          "id": "https://www.grid.ac/institutes/grid.252957.e", 
          "name": [
            "Department of Bioscience, Bengbu Medical College, 233030, Bengbu, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pu", 
        "givenName": "Yanan", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ejphar.2012.02.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000658688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-08-1643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003030877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0046404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005251295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0046404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005251295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/10590501.2013.844757", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006103989"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.83", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007412704", 
          "https://doi.org/10.1038/onc.2013.83"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2007.01.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007774118"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11523-013-0258-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009759282", 
          "https://doi.org/10.1007/s11523-013-0258-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11523-013-0258-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009759282", 
          "https://doi.org/10.1007/s11523-013-0258-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/cbi20110312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010975894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20121513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012847890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bj20121513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012847890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0054170", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016907359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2009.06.066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017353038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12011-013-9715-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018171902", 
          "https://doi.org/10.1007/s12011-013-9715-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2009.01.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018561204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-1447", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019588324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c0mb00345j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020411402"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/nu5051734", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020625585"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.e12-02-0125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022602637"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1141478", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023671304"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0027444", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025148859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa044238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025668991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4196/kjpp.2012.16.5.321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026982196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/2159-8290.cd-11-0287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029033130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/cancers5010131", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030966615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejphar.2011.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032696226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-03-0268", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032987125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1254/jphs.12052fp", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035595872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/0973-1482.98979", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036391162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3945/jn.113.177410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037843429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1747-0285.2011.01234.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038477649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12011-012-9563-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042327089", 
          "https://doi.org/10.1007/s12011-012-9563-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10616-011-9395-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042708946", 
          "https://doi.org/10.1007/s10616-011-9395-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.radonc.2009.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043172882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7314/apjcp.2014.15.15.6301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044618583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4021/jocmr1215w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048674397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0707270105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048800685"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0041179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050179034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0031539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052840487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0036813", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053537590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601913478972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064081166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1570180811666140214204858", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069202763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/1570180811666140617212723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069202797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v18.i48.7166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071368940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076870458", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077509150", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077844758", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/medicina47090069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078486442"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-05", 
    "datePublishedReg": "2015-05-01", 
    "description": "Lung cancer is presently the most commonly diagnosed metastatic tumor and the leading cause of cancer-related deaths worldwide. Moreover, drug resistance occurs frequently in lung cancer patients. There is an urgent need for developing promising anticancer drugs to improve overall survival of patients with lung cancer. In our recent antitumor drug discovery study, 1,2-di(quinazolin-4-yl)diselane (LG003) exhibited broad spectrum antitumor effects, and demonstrated such effect on A549 cells through physiological pathways rather than cytotoxicity. This suggests that compound LG003 is a potential antitumor agent. In the present study, treatment time and dosage tests indicated LG003 inhibited A549 cells in time- and dosage-dependent manner. Morphological observation did show that compound LG003 treatment resulted in inhibition of cell proliferation and morphological changes in time- and dosage-dependent manner. Subsequent cell cycle analysis revealed that LG003-induced G1-phase arrest followed by accumulation in hypodiploid population phase in cell cycle progression. The typical apoptosis-like morphological changes were also observed in synchronous observation of A549 cells. AO/EB staining and DNA ladder assay confirmed LG003-induced nuclear condensation and characteristic apoptotic DNA ladder in A549 cells. Annexin V-FITC apoptosis analysis indicated that LG003 treatment for 48 h induced the apoptosis of A549 cells in a dosage-dependent manner. Based on these results, we concluded that LG003 executed antitumor activity mainly through inhibiting cell proliferation in the early stage of treatment, then inducing apoptotic death which implied that LG003 should be a potential antitumor candidate worthing more extensive study to be developed as anticancer agents against Lung cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00044-014-1283-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7020739", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6985751", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5012572", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6982648", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1102690", 
        "issn": [
          "1054-2523", 
          "1554-8120"
        ], 
        "name": "Medicinal Chemistry Research", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "24"
      }
    ], 
    "name": "A potential anticancer agent 1,2-di(quinazolin-4-yl)diselane induces apoptosis in non-small-cell lung cancer A549 cells", 
    "pagination": "2085-2096", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0dec15bae4e4b05419b0d50ed85beb9ba72a2d70d7b4d6806396aaff8afc4d6e"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00044-014-1283-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002923167"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00044-014-1283-7", 
      "https://app.dimensions.ai/details/publication/pub.1002923167"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:40", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000503.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00044-014-1283-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00044-014-1283-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00044-014-1283-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00044-014-1283-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00044-014-1283-7'


 

This table displays all metadata directly associated to this object as RDF triples.

284 TRIPLES      21 PREDICATES      73 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00044-014-1283-7 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nc70d914171cf4e73b0b4444e02e3080f
4 schema:citation sg:pub.10.1007/s10616-011-9395-0
5 sg:pub.10.1007/s11523-013-0258-9
6 sg:pub.10.1007/s12011-012-9563-x
7 sg:pub.10.1007/s12011-013-9715-7
8 sg:pub.10.1038/onc.2013.83
9 https://app.dimensions.ai/details/publication/pub.1076870458
10 https://app.dimensions.ai/details/publication/pub.1077509150
11 https://app.dimensions.ai/details/publication/pub.1077844758
12 https://doi.org/10.1016/j.ejphar.2007.01.020
13 https://doi.org/10.1016/j.ejphar.2009.01.030
14 https://doi.org/10.1016/j.ejphar.2009.06.066
15 https://doi.org/10.1016/j.ejphar.2011.02.005
16 https://doi.org/10.1016/j.ejphar.2012.02.020
17 https://doi.org/10.1016/j.radonc.2009.09.006
18 https://doi.org/10.1039/c0mb00345j
19 https://doi.org/10.1042/bj20121513
20 https://doi.org/10.1042/cbi20110312
21 https://doi.org/10.1056/nejmoa044238
22 https://doi.org/10.1073/pnas.0707270105
23 https://doi.org/10.1080/10590501.2013.844757
24 https://doi.org/10.1091/mbc.e12-02-0125
25 https://doi.org/10.1111/j.1747-0285.2011.01234.x
26 https://doi.org/10.1126/science.1141478
27 https://doi.org/10.1158/0008-5472.can-08-1643
28 https://doi.org/10.1158/1078-0432.ccr-03-0268
29 https://doi.org/10.1158/1078-0432.ccr-08-1447
30 https://doi.org/10.1158/2159-8290.cd-11-0287
31 https://doi.org/10.1177/1947601913478972
32 https://doi.org/10.1254/jphs.12052fp
33 https://doi.org/10.1371/journal.pone.0027444
34 https://doi.org/10.1371/journal.pone.0031539
35 https://doi.org/10.1371/journal.pone.0036813
36 https://doi.org/10.1371/journal.pone.0041179
37 https://doi.org/10.1371/journal.pone.0046404
38 https://doi.org/10.1371/journal.pone.0054170
39 https://doi.org/10.2174/1570180811666140214204858
40 https://doi.org/10.2174/1570180811666140617212723
41 https://doi.org/10.3390/cancers5010131
42 https://doi.org/10.3390/medicina47090069
43 https://doi.org/10.3390/nu5051734
44 https://doi.org/10.3748/wjg.v18.i48.7166
45 https://doi.org/10.3945/jn.113.177410
46 https://doi.org/10.4021/jocmr1215w
47 https://doi.org/10.4103/0973-1482.98979
48 https://doi.org/10.4196/kjpp.2012.16.5.321
49 https://doi.org/10.7314/apjcp.2014.15.15.6301
50 schema:datePublished 2015-05
51 schema:datePublishedReg 2015-05-01
52 schema:description Lung cancer is presently the most commonly diagnosed metastatic tumor and the leading cause of cancer-related deaths worldwide. Moreover, drug resistance occurs frequently in lung cancer patients. There is an urgent need for developing promising anticancer drugs to improve overall survival of patients with lung cancer. In our recent antitumor drug discovery study, 1,2-di(quinazolin-4-yl)diselane (LG003) exhibited broad spectrum antitumor effects, and demonstrated such effect on A549 cells through physiological pathways rather than cytotoxicity. This suggests that compound LG003 is a potential antitumor agent. In the present study, treatment time and dosage tests indicated LG003 inhibited A549 cells in time- and dosage-dependent manner. Morphological observation did show that compound LG003 treatment resulted in inhibition of cell proliferation and morphological changes in time- and dosage-dependent manner. Subsequent cell cycle analysis revealed that LG003-induced G1-phase arrest followed by accumulation in hypodiploid population phase in cell cycle progression. The typical apoptosis-like morphological changes were also observed in synchronous observation of A549 cells. AO/EB staining and DNA ladder assay confirmed LG003-induced nuclear condensation and characteristic apoptotic DNA ladder in A549 cells. Annexin V-FITC apoptosis analysis indicated that LG003 treatment for 48 h induced the apoptosis of A549 cells in a dosage-dependent manner. Based on these results, we concluded that LG003 executed antitumor activity mainly through inhibiting cell proliferation in the early stage of treatment, then inducing apoptotic death which implied that LG003 should be a potential antitumor candidate worthing more extensive study to be developed as anticancer agents against Lung cancer.
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree false
56 schema:isPartOf Nb4dbb20ca2c7467dae1dfafeee635f6f
57 Nfe3eac401ca84bf4b0d873a19a340356
58 sg:journal.1102690
59 schema:name A potential anticancer agent 1,2-di(quinazolin-4-yl)diselane induces apoptosis in non-small-cell lung cancer A549 cells
60 schema:pagination 2085-2096
61 schema:productId N7d77c3d3dc734ee5875d437b7deefcf6
62 N8e872b655a5d42adacd09c27012ad369
63 N9b6bbd82a3604d54bdd0e21f4892f8e7
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002923167
65 https://doi.org/10.1007/s00044-014-1283-7
66 schema:sdDatePublished 2019-04-10T16:40
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher N06516ff41e024e73bc35a8048c4016a4
69 schema:url http://link.springer.com/10.1007%2Fs00044-014-1283-7
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N06516ff41e024e73bc35a8048c4016a4 schema:name Springer Nature - SN SciGraph project
74 rdf:type schema:Organization
75 N100418061d3b46a18e97c003fcad1db2 rdf:first sg:person.01200601705.15
76 rdf:rest N10a4c5cde85b430aaf645af21879ef7e
77 N10597fc0dc844185b559b3fdd962ffb2 rdf:first sg:person.014237122137.17
78 rdf:rest N100418061d3b46a18e97c003fcad1db2
79 N10a4c5cde85b430aaf645af21879ef7e rdf:first sg:person.014457467742.18
80 rdf:rest Nc248af5d012d4eb885a76beb7dfb63bd
81 N273305e3e0e047d999e8cee69681ba3b rdf:first Nb560e92c475a4834bd6eac3b15b0af2b
82 rdf:rest rdf:nil
83 N3455c8cbd9b24f5b94608c5e494a430a schema:affiliation https://www.grid.ac/institutes/grid.414884.5
84 schema:familyName Qian
85 schema:givenName Jun
86 rdf:type schema:Person
87 N6d8e34f3687d4932a0139a0e1a7bd465 rdf:first sg:person.07674254222.12
88 rdf:rest N7bc632c9c140493695b166ae7d526740
89 N7bc632c9c140493695b166ae7d526740 rdf:first sg:person.01212142420.00
90 rdf:rest N10597fc0dc844185b559b3fdd962ffb2
91 N7d77c3d3dc734ee5875d437b7deefcf6 schema:name readcube_id
92 schema:value 0dec15bae4e4b05419b0d50ed85beb9ba72a2d70d7b4d6806396aaff8afc4d6e
93 rdf:type schema:PropertyValue
94 N8e872b655a5d42adacd09c27012ad369 schema:name doi
95 schema:value 10.1007/s00044-014-1283-7
96 rdf:type schema:PropertyValue
97 N9b6bbd82a3604d54bdd0e21f4892f8e7 schema:name dimensions_id
98 schema:value pub.1002923167
99 rdf:type schema:PropertyValue
100 Nb1b3a020b8284fb582f2187cf2f6f22d schema:affiliation https://www.grid.ac/institutes/grid.252957.e
101 schema:familyName Zhang
102 schema:givenName Yuyuan
103 rdf:type schema:Person
104 Nb4dbb20ca2c7467dae1dfafeee635f6f schema:issueNumber 5
105 rdf:type schema:PublicationIssue
106 Nb560e92c475a4834bd6eac3b15b0af2b schema:affiliation https://www.grid.ac/institutes/grid.252957.e
107 schema:familyName Pu
108 schema:givenName Yanan
109 rdf:type schema:Person
110 Nb56bf8490d834aeca477a3c2dd1f8ff1 rdf:first Nc225d803ff9b49768474fb4b752eb804
111 rdf:rest N6d8e34f3687d4932a0139a0e1a7bd465
112 Nc225d803ff9b49768474fb4b752eb804 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
113 schema:familyName Hu
114 schema:givenName Xiaomei
115 rdf:type schema:Person
116 Nc248af5d012d4eb885a76beb7dfb63bd rdf:first N3455c8cbd9b24f5b94608c5e494a430a
117 rdf:rest Nf0b1ddee5b8e47e6bed5146ac1cd6ecb
118 Nc70d914171cf4e73b0b4444e02e3080f rdf:first sg:person.014555453641.32
119 rdf:rest Nb56bf8490d834aeca477a3c2dd1f8ff1
120 Need272e71359406b954cbd03f608588e rdf:first Nb1b3a020b8284fb582f2187cf2f6f22d
121 rdf:rest N273305e3e0e047d999e8cee69681ba3b
122 Nf0b1ddee5b8e47e6bed5146ac1cd6ecb rdf:first sg:person.01363533155.19
123 rdf:rest Need272e71359406b954cbd03f608588e
124 Nfe3eac401ca84bf4b0d873a19a340356 schema:volumeNumber 24
125 rdf:type schema:PublicationVolume
126 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
127 schema:name Medical and Health Sciences
128 rdf:type schema:DefinedTerm
129 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
130 schema:name Oncology and Carcinogenesis
131 rdf:type schema:DefinedTerm
132 sg:grant.5012572 http://pending.schema.org/fundedItem sg:pub.10.1007/s00044-014-1283-7
133 rdf:type schema:MonetaryGrant
134 sg:grant.6982648 http://pending.schema.org/fundedItem sg:pub.10.1007/s00044-014-1283-7
135 rdf:type schema:MonetaryGrant
136 sg:grant.6985751 http://pending.schema.org/fundedItem sg:pub.10.1007/s00044-014-1283-7
137 rdf:type schema:MonetaryGrant
138 sg:grant.7020739 http://pending.schema.org/fundedItem sg:pub.10.1007/s00044-014-1283-7
139 rdf:type schema:MonetaryGrant
140 sg:journal.1102690 schema:issn 1054-2523
141 1554-8120
142 schema:name Medicinal Chemistry Research
143 rdf:type schema:Periodical
144 sg:person.01200601705.15 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
145 schema:familyName Feng
146 schema:givenName Zhenzhong
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01200601705.15
148 rdf:type schema:Person
149 sg:person.01212142420.00 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
150 schema:familyName Liu
151 schema:givenName Hao
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212142420.00
153 rdf:type schema:Person
154 sg:person.01363533155.19 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
155 schema:familyName Wang
156 schema:givenName Qiyi
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01363533155.19
158 rdf:type schema:Person
159 sg:person.014237122137.17 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
160 schema:familyName Hu
161 schema:givenName Jianguo
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014237122137.17
163 rdf:type schema:Person
164 sg:person.014457467742.18 schema:affiliation https://www.grid.ac/institutes/grid.414884.5
165 schema:familyName Tang
166 schema:givenName Bi
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014457467742.18
168 rdf:type schema:Person
169 sg:person.014555453641.32 schema:affiliation https://www.grid.ac/institutes/grid.252957.e
170 schema:familyName Huang
171 schema:givenName Yinjiu
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014555453641.32
173 rdf:type schema:Person
174 sg:person.07674254222.12 schema:affiliation https://www.grid.ac/institutes/grid.443651.1
175 schema:familyName Liu
176 schema:givenName Gang
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07674254222.12
178 rdf:type schema:Person
179 sg:pub.10.1007/s10616-011-9395-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042708946
180 https://doi.org/10.1007/s10616-011-9395-0
181 rdf:type schema:CreativeWork
182 sg:pub.10.1007/s11523-013-0258-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009759282
183 https://doi.org/10.1007/s11523-013-0258-9
184 rdf:type schema:CreativeWork
185 sg:pub.10.1007/s12011-012-9563-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042327089
186 https://doi.org/10.1007/s12011-012-9563-x
187 rdf:type schema:CreativeWork
188 sg:pub.10.1007/s12011-013-9715-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018171902
189 https://doi.org/10.1007/s12011-013-9715-7
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/onc.2013.83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007412704
192 https://doi.org/10.1038/onc.2013.83
193 rdf:type schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1076870458 schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1077509150 schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1077844758 schema:CreativeWork
197 https://doi.org/10.1016/j.ejphar.2007.01.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007774118
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1016/j.ejphar.2009.01.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018561204
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1016/j.ejphar.2009.06.066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017353038
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.ejphar.2011.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032696226
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.ejphar.2012.02.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000658688
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.radonc.2009.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043172882
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1039/c0mb00345j schema:sameAs https://app.dimensions.ai/details/publication/pub.1020411402
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1042/bj20121513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012847890
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1042/cbi20110312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010975894
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1056/nejmoa044238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025668991
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1073/pnas.0707270105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048800685
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1080/10590501.2013.844757 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006103989
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1091/mbc.e12-02-0125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022602637
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1111/j.1747-0285.2011.01234.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1038477649
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1126/science.1141478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023671304
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1158/0008-5472.can-08-1643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003030877
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1158/1078-0432.ccr-03-0268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032987125
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1158/1078-0432.ccr-08-1447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019588324
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1158/2159-8290.cd-11-0287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029033130
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1177/1947601913478972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064081166
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1254/jphs.12052fp schema:sameAs https://app.dimensions.ai/details/publication/pub.1035595872
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1371/journal.pone.0027444 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025148859
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1371/journal.pone.0031539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052840487
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1371/journal.pone.0036813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053537590
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1371/journal.pone.0041179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050179034
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1371/journal.pone.0046404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005251295
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1371/journal.pone.0054170 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016907359
250 rdf:type schema:CreativeWork
251 https://doi.org/10.2174/1570180811666140214204858 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069202763
252 rdf:type schema:CreativeWork
253 https://doi.org/10.2174/1570180811666140617212723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069202797
254 rdf:type schema:CreativeWork
255 https://doi.org/10.3390/cancers5010131 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030966615
256 rdf:type schema:CreativeWork
257 https://doi.org/10.3390/medicina47090069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078486442
258 rdf:type schema:CreativeWork
259 https://doi.org/10.3390/nu5051734 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020625585
260 rdf:type schema:CreativeWork
261 https://doi.org/10.3748/wjg.v18.i48.7166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071368940
262 rdf:type schema:CreativeWork
263 https://doi.org/10.3945/jn.113.177410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037843429
264 rdf:type schema:CreativeWork
265 https://doi.org/10.4021/jocmr1215w schema:sameAs https://app.dimensions.ai/details/publication/pub.1048674397
266 rdf:type schema:CreativeWork
267 https://doi.org/10.4103/0973-1482.98979 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036391162
268 rdf:type schema:CreativeWork
269 https://doi.org/10.4196/kjpp.2012.16.5.321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026982196
270 rdf:type schema:CreativeWork
271 https://doi.org/10.7314/apjcp.2014.15.15.6301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044618583
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.252957.e schema:alternateName Bengbu Medical College
274 schema:name Department of Bioscience, Bengbu Medical College, 233030, Bengbu, People’s Republic of China
275 Department of Pathology, Bengbu Medical College, 233030, Bengbu, People’s Republic of China
276 Faculty of Pharmacy, Bengbu Medical College, 233030, Bengbu, Anhui, People’s Republic of China
277 Scientific Research Center, Bengbu Medical College, 233030, Bengbu, People’s Republic of China
278 rdf:type schema:Organization
279 https://www.grid.ac/institutes/grid.414884.5 schema:alternateName First Affiliated Hospital of Bengbu Medical College
280 schema:name The First Affiliated Hospital of Bengbu Medical College, 233030, Bengbu, People’s Republic of China
281 rdf:type schema:Organization
282 https://www.grid.ac/institutes/grid.443651.1 schema:alternateName Ludong University
283 schema:name School of Chemistry and Materials Science, Ludong University, 264025, Yantai, People’s Republic of China
284 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...