Design and synthesis of thienopyridines as novel templates for acetylcholinesterase inhibitors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-09

AUTHORS

Mohga M. Badran, Maha Abdel Hakeem, Suzan M. Abuel-Maaty, Afaf El-Malah, Rania M. Abdel Salam

ABSTRACT

New dual binding site acetylcholinesterase (AChE) inhibitors have been designed and synthesized as a new drug candidate for the treatment of Alzheimer’s disease (AD) through the binding to both catalytic and peripheral sites of the enzyme. Therefore, a series of thienopyridine analogs of tacrine were synthesized and investigated for their ability to inhibit the activity of AChE in comparison with tacrine. All the compounds were found to inhibit AChE activity, especially compounds 7b and 11a, which were found to be more potent than tacrine. More... »

PAGES

4087-4095

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-012-0403-5

DOI

http://dx.doi.org/10.1007/s00044-012-0403-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036341339


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136 schema:name Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Kaser El-Aini Street, P.O. Box 11562, Giza, Egypt
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