Efficient entry to diversely functionalized spirooxindoles from isatin and their biological activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

Mazaahir Kidwai, Arti Jain, Vishal Nemaysh, Rakesh Kumar, Pratibha Mehta Luthra

ABSTRACT

A collection of structurally complex and chemically diverse small molecules is a useful tool to explore cell circuitry. In this article, we have reported the two step synthesis of diverse spirooxindoles. The key reaction to assemble the spirooxindole core is a Lewis acid catalyzed three component coupling. The final library of compounds was then analyzed for their cytotoxic activity against U87 human glioma cells. It is noteworthy to mention that this is the first report on the pharmaceutical evaluation of such compounds. Although the activity is moderate, it opens the door for new chemical modifications of spirooxindoles. More... »

PAGES

2717-2723

References to SciGraph publications

Journal

TITLE

Medicinal Chemistry Research

ISSUE

6

VOLUME

22

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-012-0249-x

DOI

http://dx.doi.org/10.1007/s00044-012-0249-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025040215


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