Effect of complexation of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxides with palladium and copper on their anti-T. cruzi activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-07

AUTHORS

Diego Benítez, María L. Lavaggi, Dinorah Gambino, María H. Torre, Hugo Cerecetto, Mercedes González

ABSTRACT

Pd(II) and Cu(II) complexes of 3-aminoquinoxaline-2-carbonitrile 1,4-dioxides were prepared in order to improve the anti-Trypanosoma cruzi activity of these ligands. The in vitro evaluations demonstrated that the metal complexation modified the activity of the ligands in different manners. Except for one compound, complexation with palladium increased the trypanosomicidal activity 20–80-times. Besides, copper also modified favorably the activity, however, the copper compounds resulted less active than the palladium ones, at the studied doses. More... »

PAGES

1439-1444

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00044-011-9660-y

DOI

http://dx.doi.org/10.1007/s00044-011-9660-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046209982


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