Social insect colony size is correlated with rates of molecular evolution View Full Text


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Article Info

DATE

2022-04-27

AUTHORS

B. E. R. Rubin

ABSTRACT

Larger numbers of germline cell divisions can increase the number of mutations inherited by offspring. Therefore, in systems where the number of offspring is dependent on the number of germline cell divisions, a higher overall rate of molecular evolution may be expected. Here, I examine whether colony size in social insects, which varies from tens to millions, influences molecular evolutionary rates via this mechanism. Comparative analyses of whole genomes from three clades of social insects, including eight species in the ant genus Pseudomyrmex, seven fungus-growing ants, and 11 bees, reveal that rates of molecular evolution are positively correlated with colony size. The additional germline cell divisions necessary to maintain large colony sizes may lead to mutation accumulation in the germlines of queens of these species, a process similar to that which occurs in aging human males. Among species with large colonies, I also find a weak signal of intensified constraint on DNA repair genes. This pattern suggests the intriguing possibility that the additional mutations that occur in these taxa may increase selective pressure for replication fidelity. Finally, I find that colony size is negatively associated with GC-content in five highly conserved genes across 115 ant genera, a pattern consistent with a positive relationship between substitution rate and colony size. Colony size, a fundamental facet of eusociality, appears to play a previously unappreciated role in genome evolution. More... »

PAGES

147-157

References to SciGraph publications

  • 1997-10. Extraordinary lifespans in ants: a test of evolutionary theories of ageing in NATURE
  • 2013-07-11. De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis in NATURE PROTOCOLS
  • 2017-09-20. Parental influence on human germline de novo mutations in 1,548 trios from Iceland in NATURE
  • 2006-10. Insights into social insects from the genome of the honeybee Apis mellifera in NATURE
  • 2006-08-07. AUGUSTUS at EGASP: using EST, protein and genomic alignments for improved gene prediction in the human genome in GENOME BIOLOGY
  • 2011-05-15. Full-length transcriptome assembly from RNA-Seq data without a reference genome in NATURE BIOTECHNOLOGY
  • 2014-08-20. Comparative population genomics in animals uncovers the determinants of genetic diversity in NATURE
  • 2011-04-28. Proteinortho: Detection of (Co-)orthologs in large-scale analysis in BMC BIOINFORMATICS
  • 1998-08. Queen lifespan and colony characteristics in ants and termites in INSECTES SOCIAUX
  • 2015-04-24. The genomes of two key bumblebee species with primitive eusocial organization in GENOME BIOLOGY
  • 2016-08-25. Comparative genomics reveals convergent rates of evolution in ant–plant mutualisms in NATURE COMMUNICATIONS
  • 2014-01-30. Finding the missing honey bee genes: lessons learned from a genome upgrade in BMC GENOMICS
  • 1994. The Insect Ovary, Ultrastructure, previtellogenic growth and evolution in NONE
  • 2011-12-22. MAKER2: an annotation pipeline and genome-database management tool for second-generation genome projects in BMC BIOINFORMATICS
  • 2019-04-25. BUSCO: Assessing Genome Assembly and Annotation Completeness in GENE PREDICTION
  • 2013-06-19. Parasitic plants have increased rates of molecular evolution across all three genomes in BMC ECOLOGY AND EVOLUTION
  • 1987-11. Very slightly deleterious mutations and the molecular clock in JOURNAL OF MOLECULAR EVOLUTION
  • 2016-07-20. Reciprocal genomic evolution in the ant–fungus agricultural symbiosis in NATURE COMMUNICATIONS
  • 2012-08-22. Rate of de novo mutations and the importance of father’s age to disease risk in NATURE
  • 2015-03-09. HISAT: a fast spliced aligner with low memory requirements in NATURE METHODS
  • 1991-06. Life span of queens in the antFormica exsecta in INSECTES SOCIAUX
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