The functions of mucosal T cells in containing the indigenous commensal flora of the intestine View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2002-12

AUTHORS

A. J. Macpherson, M. M. Martinic, N. Harris

ABSTRACT

. There is an immense load of non-pathogenic commensal bacteria in the distal small intestine and the colon of mammals. The physical barrier that prevents penetration (translocation) of these organisms into the body is a simple epithelium comprised of the single enterocyte/colonocyte cell layer with its overlying mucus. In this review, we discuss the roles of intestinal T cells in initiating and regulating innate and adaptive mucosal immune responses of the mucosal immune system that avoid or limit penetration of the commensal intestinal bacteria. More... »

PAGES

2088-2096

Journal

TITLE

Cellular and Molecular Life Sciences

ISSUE

12

VOLUME

59

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s000180200009

DOI

http://dx.doi.org/10.1007/s000180200009

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017777892

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12568335


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