The modular nature of apoptotic signaling proteins View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-07

AUTHORS

K. Hofmann

ABSTRACT

. Apoptosis, initiated by a variety of stimuli, is a physiological process that engages a well-ordered signaling cascade, eventually leading to the controlled death of the cell. The most extensively studied apoptotic stimulus is the binding of death receptors related to CD95 (Fas/Apo1) by their respective ligands. During the last years, a considerable number of proteins have been identified which act together in the receptor-proximal part of the signaling pathway. Based on localized regions of sequence similarity, it has been predicted that these proteins consist of several independently folding domains. In several cases these predictions have been confirmed by structural studies; in other cases they are at least supported by experimental data. This review focuses on the three most widespread domain families found in the apoptotic signaling proteins: the death domain, the death effector domain and the caspase recruitment domain. The recently discovered analogies between these domains, both in structure and in function, have shed some light on the overall architecture of the pathway leading from death receptor ligation to the activation of caspases and eventually to the apoptotic phenotype. More... »

PAGES

1113-1128

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s000180050361

DOI

http://dx.doi.org/10.1007/s000180050361

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053095183

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10442092


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