Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-03

AUTHORS

A.-C. Bergman, A. A. Alaiya, W. Wendler, B. Binetruy, M. Shoshan, K. Sakaguchi, T. Bergman, U. Kronenwett, G. Auer, E. Appella, H. Jörnvall, S. Linder

ABSTRACT

Signalling via the protein kinase Raf-MEK-ERK pathway is of major importance for transformation by oncogenes. To identify genes affected by inhibition of this pathway, c-JUN transformed rat fibroblasts were treated with a MEK1 inhibitor (PD98059) and subjected to two-dimensional gel electrophoresis after cell lysis. Gene products with expression influenced by MEK1 inhibition were determined by mass spectrometry of fragments from in-gel tryptic digestions. The expression of pirin, a nuclear factor I-interacting protein, was lowered after inhibition of MEK1. Western blot analysis revealed increased expression of pirin in RAS and c-JUN transformed cells in the absence of PD98059. Inhibition of MEK1 also led to reduced expression of alpha-enolase, phosphoglycerate kinase, elongation factor 2 and heterogeneous nuclear ribonucleoprotein A3, the latter two being detected as truncated proteins. In contrast, the level of ornithine aminotransferase was increased. We conclude that inhibition of MEK1 results in major alterations of protein expression in c-JUN transformed cells, suggesting that this pathway is important for oncogene-induced phenotypic changes. More... »

PAGES

467-471

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s000180050303

DOI

http://dx.doi.org/10.1007/s000180050303

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031448533

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10228560


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Calcium-Calmodulin-Dependent Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Transformed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Neoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibroblasts", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flavonoids", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, jun", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, ras", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterogeneous-Nuclear Ribonucleoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MAP Kinase Kinase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mass Spectrometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinase Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitogen-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ornithine-Oxo-Acid Transaminase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Elongation Factor 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptide Elongation Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphoglycerate Kinase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphopyruvate Hydratase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Tyrosine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proto-Oncogene Proteins c-raf", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ribonucleoproteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm (Sweden), SE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergman", 
        "givenName": "A.-C.", 
        "id": "sg:person.01256046515.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256046515.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.24381.3c", 
          "name": [
            "Unit of Cell and Molecular Analysis, Department of Oncology and Pathology, Karolinska Hospital, S-171 76 Stockholm (Sweden), SE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alaiya", 
        "givenName": "A. A.", 
        "id": "sg:person.01176606644.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176606644.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Biochemistry, Ludwig-Maximilian-University, Feodor-L\u00fcnen-Str. 25, D-81377 M\u00fcnchen (Germany), DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wendler", 
        "givenName": "W.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "French National Centre for Scientific Research", 
          "id": "https://www.grid.ac/institutes/grid.4444.0", 
          "name": [
            "Department of Cancer Research, National Center of Scientific Research, F-94801 Villejuif (France), FR"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Binetruy", 
        "givenName": "B.", 
        "id": "sg:person.0632061147.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632061147.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.24381.3c", 
          "name": [
            "Radiumhemmet's Research Laboratory, Department of Oncology and Pathology, Karolinska Hospital, S-171 76 Stockholm (Sweden), SE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shoshan", 
        "givenName": "M.", 
        "id": "sg:person.01103641055.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103641055.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda (Maryland 20892, USA), US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakaguchi", 
        "givenName": "K.", 
        "id": "sg:person.012455605442.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012455605442.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm (Sweden), SE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergman", 
        "givenName": "T.", 
        "id": "sg:person.0607361633.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607361633.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.24381.3c", 
          "name": [
            "Radiumhemmet's Research Laboratory, Department of Oncology and Pathology, Karolinska Hospital, S-171 76 Stockholm (Sweden), SE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kronenwett", 
        "givenName": "U.", 
        "id": "sg:person.01170031060.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170031060.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.24381.3c", 
          "name": [
            "Unit of Cell and Molecular Analysis, Department of Oncology and Pathology, Karolinska Hospital, S-171 76 Stockholm (Sweden), SE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Auer", 
        "givenName": "G.", 
        "id": "sg:person.01314041754.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314041754.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda (Maryland 20892, USA), US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Appella", 
        "givenName": "E.", 
        "id": "sg:person.01050473225.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050473225.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm (Sweden), SE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00f6rnvall", 
        "givenName": "H.", 
        "id": "sg:person.01211407472.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211407472.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.24381.3c", 
          "name": [
            "Radiumhemmet's Research Laboratory, Department of Oncology and Pathology, Karolinska Hospital, S-171 76 Stockholm (Sweden), SE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Linder", 
        "givenName": "S.", 
        "id": "sg:person.01050565740.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050565740.93"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1999-03", 
    "datePublishedReg": "1999-03-01", 
    "description": "Signalling via the protein kinase Raf-MEK-ERK pathway is of major importance for transformation by oncogenes. To identify genes affected by inhibition of this pathway, c-JUN transformed rat fibroblasts were treated with a MEK1 inhibitor (PD98059) and subjected to two-dimensional gel electrophoresis after cell lysis. Gene products with expression influenced by MEK1 inhibition were determined by mass spectrometry of fragments from in-gel tryptic digestions. The expression of pirin, a nuclear factor I-interacting protein, was lowered after inhibition of MEK1. Western blot analysis revealed increased expression of pirin in RAS and c-JUN transformed cells in the absence of PD98059. Inhibition of MEK1 also led to reduced expression of alpha-enolase, phosphoglycerate kinase, elongation factor 2 and heterogeneous nuclear ribonucleoprotein A3, the latter two being detected as truncated proteins. In contrast, the level of ornithine aminotransferase was increased. We conclude that inhibition of MEK1 results in major alterations of protein expression in c-JUN transformed cells, suggesting that this pathway is important for oncogene-induced phenotypic changes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s000180050303", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2710033", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2723548", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295005", 
        "issn": [
          "1420-682X", 
          "1420-9071"
        ], 
        "name": "Cellular and Molecular Life Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "name": "Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts", 
    "pagination": "467-471", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "95d0757df21d9e00375a342da025e5dbb3c2893c298763c56db860b4ef47e5af"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10228560"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9705402"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s000180050303"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031448533"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s000180050303", 
      "https://app.dimensions.ai/details/publication/pub.1031448533"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:11", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000495.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s000180050303"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s000180050303'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s000180050303'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s000180050303'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s000180050303'


 

This table displays all metadata directly associated to this object as RDF triples.

277 TRIPLES      20 PREDICATES      58 URIs      50 LITERALS      38 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s000180050303 schema:about N02af625bbcd14932a94e8e070ad5b4d0
2 N0faa665e4afd47a682908307c7c8f9c9
3 N1ac0ab7b3b2c46588eb3ecf7cc33844d
4 N1cd8a14a1be1428a91a564d60b1de92e
5 N2016cb5b8fba439ab4a64594af5569df
6 N25b34a7f0669499ab5c43c56d2c4bcf7
7 N2f15617a681045289594c760bef04de7
8 N2ff818e142ee4213bce6c7176db95191
9 N4079f878e0d240cb8d03e5c753ffa1ff
10 N40e6a216893e42228a65f64f59dd0d8a
11 N46539375f9f041c4a92669088a1029c3
12 N48e5a1a44caf495fb708c971776110a5
13 N4d716fb28b2349dc928fc722d12beaf6
14 N59e3480087674808af1e49a002cb7167
15 N5a4ababdbcc04799877349f3e9295d76
16 N681ace238fa3461da9180ea2fc48be6f
17 N72deee44c7f543d5bd6a9e0c03de3b44
18 N74b4654a67094c95b708f4c0f5c22cec
19 N802cc8f8725d4ff69f6e9c53d800e6d3
20 N8126b9f9f5874efcb3ce141f9a8bbac4
21 Nc9cf57f2786c449ab77b1bf1a90d62eb
22 Nd18faf9b7ff8463c806e1edda32c1750
23 Nd3d9837fc8754b8a94e8a6caca705c5a
24 Ne082feebf62f460f983525ee5e91a3d2
25 Ne8ba77be79664a3cae8047c8dedc4f15
26 Nf10f4f67f1114b00a18ee80037709523
27 Nf6d11ae6af714879b14450175d76d387
28 Nfb78070127b7456eb46e6f5d85da2ce4
29 Nfde732ca47e9439ca47a1caea7f50c9f
30 anzsrc-for:06
31 anzsrc-for:0601
32 schema:author Na80002fc2e3647fe8a24276da5a199fa
33 schema:datePublished 1999-03
34 schema:datePublishedReg 1999-03-01
35 schema:description Signalling via the protein kinase Raf-MEK-ERK pathway is of major importance for transformation by oncogenes. To identify genes affected by inhibition of this pathway, c-JUN transformed rat fibroblasts were treated with a MEK1 inhibitor (PD98059) and subjected to two-dimensional gel electrophoresis after cell lysis. Gene products with expression influenced by MEK1 inhibition were determined by mass spectrometry of fragments from in-gel tryptic digestions. The expression of pirin, a nuclear factor I-interacting protein, was lowered after inhibition of MEK1. Western blot analysis revealed increased expression of pirin in RAS and c-JUN transformed cells in the absence of PD98059. Inhibition of MEK1 also led to reduced expression of alpha-enolase, phosphoglycerate kinase, elongation factor 2 and heterogeneous nuclear ribonucleoprotein A3, the latter two being detected as truncated proteins. In contrast, the level of ornithine aminotransferase was increased. We conclude that inhibition of MEK1 results in major alterations of protein expression in c-JUN transformed cells, suggesting that this pathway is important for oncogene-induced phenotypic changes.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf Nb79801f638a54ced95d49b49e7f19359
40 Nff5642cd0ec7405a83dff88d1a2def8a
41 sg:journal.1295005
42 schema:name Protein kinase-dependent overexpression of the nuclear protein pirin in c-JUN and RAS transformed fibroblasts
43 schema:pagination 467-471
44 schema:productId N3e52b0406ad344608b238cee3f0cdb6f
45 Na400957affa4428fafaac045b2f3e89b
46 Nb7ce325aa6f04971bef4cf977d285c30
47 Ndcc82ef956254b4694bbc02c631ff1c7
48 Nfe184ce116fc4e3db16d8cf05e9b3b9f
49 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031448533
50 https://doi.org/10.1007/s000180050303
51 schema:sdDatePublished 2019-04-10T13:11
52 schema:sdLicense https://scigraph.springernature.com/explorer/license/
53 schema:sdPublisher N1fe46de69a1641b8a4c9ce1bafba969c
54 schema:url http://link.springer.com/10.1007/s000180050303
55 sgo:license sg:explorer/license/
56 sgo:sdDataset articles
57 rdf:type schema:ScholarlyArticle
58 N02af625bbcd14932a94e8e070ad5b4d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
59 schema:name Ribonucleoproteins
60 rdf:type schema:DefinedTerm
61 N0faa665e4afd47a682908307c7c8f9c9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
62 schema:name Cell Line, Transformed
63 rdf:type schema:DefinedTerm
64 N1ac0ab7b3b2c46588eb3ecf7cc33844d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name MAP Kinase Kinase 1
66 rdf:type schema:DefinedTerm
67 N1cd8a14a1be1428a91a564d60b1de92e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Genes, ras
69 rdf:type schema:DefinedTerm
70 N1d6b9a9a79ff40d8b3f52ba4a8240755 rdf:first Nf56667b006e3448dac97f9d59928c456
71 rdf:rest N4b4cfd7693f94bc5ad0ea6f5c25582de
72 N1fe46de69a1641b8a4c9ce1bafba969c schema:name Springer Nature - SN SciGraph project
73 rdf:type schema:Organization
74 N201066a7700d4385b960b8731cc88640 rdf:first sg:person.0607361633.91
75 rdf:rest N8ffaba78e9b54b3e98ffd9dbbdeee4f2
76 N2016cb5b8fba439ab4a64594af5569df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Mitogen-Activated Protein Kinase 3
78 rdf:type schema:DefinedTerm
79 N21f3446f8b1342e3b69b39489461f31d rdf:first sg:person.012455605442.40
80 rdf:rest N201066a7700d4385b960b8731cc88640
81 N25b34a7f0669499ab5c43c56d2c4bcf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Proto-Oncogene Proteins c-raf
83 rdf:type schema:DefinedTerm
84 N2a0388f1dc0d43e79de31ef95dab7ee9 schema:name Department of Biochemistry, Ludwig-Maximilian-University, Feodor-Lünen-Str. 25, D-81377 München (Germany), DE
85 rdf:type schema:Organization
86 N2f15617a681045289594c760bef04de7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Ornithine-Oxo-Acid Transaminase
88 rdf:type schema:DefinedTerm
89 N2ff818e142ee4213bce6c7176db95191 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Peptide Elongation Factor 2
91 rdf:type schema:DefinedTerm
92 N3e52b0406ad344608b238cee3f0cdb6f schema:name pubmed_id
93 schema:value 10228560
94 rdf:type schema:PropertyValue
95 N4079f878e0d240cb8d03e5c753ffa1ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Carrier Proteins
97 rdf:type schema:DefinedTerm
98 N40e6a216893e42228a65f64f59dd0d8a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Nuclear Proteins
100 rdf:type schema:DefinedTerm
101 N46539375f9f041c4a92669088a1029c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Heterogeneous-Nuclear Ribonucleoproteins
103 rdf:type schema:DefinedTerm
104 N48e5a1a44caf495fb708c971776110a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Rats
106 rdf:type schema:DefinedTerm
107 N4b4cfd7693f94bc5ad0ea6f5c25582de rdf:first sg:person.0632061147.30
108 rdf:rest N886e8f0e8fea43cba1e243d092b56292
109 N4d716fb28b2349dc928fc722d12beaf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Flavonoids
111 rdf:type schema:DefinedTerm
112 N59e3480087674808af1e49a002cb7167 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Mitogen-Activated Protein Kinase 1
114 rdf:type schema:DefinedTerm
115 N5a4ababdbcc04799877349f3e9295d76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Genes, jun
117 rdf:type schema:DefinedTerm
118 N681ace238fa3461da9180ea2fc48be6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Protein-Tyrosine Kinases
120 rdf:type schema:DefinedTerm
121 N6dda827f60b346a8858ae0b02fc336f2 rdf:first sg:person.01050473225.52
122 rdf:rest Nc79fca09cfaa4668bde9a24edac197ce
123 N72deee44c7f543d5bd6a9e0c03de3b44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Cell Transformation, Neoplastic
125 rdf:type schema:DefinedTerm
126 N74b4654a67094c95b708f4c0f5c22cec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Protein-Serine-Threonine Kinases
128 rdf:type schema:DefinedTerm
129 N802cc8f8725d4ff69f6e9c53d800e6d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Animals
131 rdf:type schema:DefinedTerm
132 N8126b9f9f5874efcb3ce141f9a8bbac4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Calcium-Calmodulin-Dependent Protein Kinases
134 rdf:type schema:DefinedTerm
135 N886e8f0e8fea43cba1e243d092b56292 rdf:first sg:person.01103641055.71
136 rdf:rest N21f3446f8b1342e3b69b39489461f31d
137 N8ffaba78e9b54b3e98ffd9dbbdeee4f2 rdf:first sg:person.01170031060.85
138 rdf:rest Ne16b287bb59f45b89045e6c3c74dc2b3
139 N9d0cf70c23bd49fb89f9139c41ad5c2e rdf:first sg:person.01176606644.55
140 rdf:rest N1d6b9a9a79ff40d8b3f52ba4a8240755
141 Na400957affa4428fafaac045b2f3e89b schema:name readcube_id
142 schema:value 95d0757df21d9e00375a342da025e5dbb3c2893c298763c56db860b4ef47e5af
143 rdf:type schema:PropertyValue
144 Na80002fc2e3647fe8a24276da5a199fa rdf:first sg:person.01256046515.23
145 rdf:rest N9d0cf70c23bd49fb89f9139c41ad5c2e
146 Nb79801f638a54ced95d49b49e7f19359 schema:volumeNumber 55
147 rdf:type schema:PublicationVolume
148 Nb7ce325aa6f04971bef4cf977d285c30 schema:name dimensions_id
149 schema:value pub.1031448533
150 rdf:type schema:PropertyValue
151 Nc79fca09cfaa4668bde9a24edac197ce rdf:first sg:person.01211407472.30
152 rdf:rest Nd5a2136506184351b2f80682a7845368
153 Nc9cf57f2786c449ab77b1bf1a90d62eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Transfection
155 rdf:type schema:DefinedTerm
156 Nd18faf9b7ff8463c806e1edda32c1750 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Signal Transduction
158 rdf:type schema:DefinedTerm
159 Nd3d9837fc8754b8a94e8a6caca705c5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Mitogen-Activated Protein Kinase Kinases
161 rdf:type schema:DefinedTerm
162 Nd5a2136506184351b2f80682a7845368 rdf:first sg:person.01050565740.93
163 rdf:rest rdf:nil
164 Ndcc82ef956254b4694bbc02c631ff1c7 schema:name doi
165 schema:value 10.1007/s000180050303
166 rdf:type schema:PropertyValue
167 Ne082feebf62f460f983525ee5e91a3d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Fibroblasts
169 rdf:type schema:DefinedTerm
170 Ne16b287bb59f45b89045e6c3c74dc2b3 rdf:first sg:person.01314041754.28
171 rdf:rest N6dda827f60b346a8858ae0b02fc336f2
172 Ne8ba77be79664a3cae8047c8dedc4f15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Phosphoglycerate Kinase
174 rdf:type schema:DefinedTerm
175 Nf10f4f67f1114b00a18ee80037709523 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Phosphopyruvate Hydratase
177 rdf:type schema:DefinedTerm
178 Nf56667b006e3448dac97f9d59928c456 schema:affiliation N2a0388f1dc0d43e79de31ef95dab7ee9
179 schema:familyName Wendler
180 schema:givenName W.
181 rdf:type schema:Person
182 Nf6d11ae6af714879b14450175d76d387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Mitogen-Activated Protein Kinases
184 rdf:type schema:DefinedTerm
185 Nfb78070127b7456eb46e6f5d85da2ce4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Peptide Elongation Factors
187 rdf:type schema:DefinedTerm
188 Nfde732ca47e9439ca47a1caea7f50c9f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Mass Spectrometry
190 rdf:type schema:DefinedTerm
191 Nfe184ce116fc4e3db16d8cf05e9b3b9f schema:name nlm_unique_id
192 schema:value 9705402
193 rdf:type schema:PropertyValue
194 Nff5642cd0ec7405a83dff88d1a2def8a schema:issueNumber 3
195 rdf:type schema:PublicationIssue
196 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
197 schema:name Biological Sciences
198 rdf:type schema:DefinedTerm
199 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
200 schema:name Biochemistry and Cell Biology
201 rdf:type schema:DefinedTerm
202 sg:grant.2710033 http://pending.schema.org/fundedItem sg:pub.10.1007/s000180050303
203 rdf:type schema:MonetaryGrant
204 sg:grant.2723548 http://pending.schema.org/fundedItem sg:pub.10.1007/s000180050303
205 rdf:type schema:MonetaryGrant
206 sg:journal.1295005 schema:issn 1420-682X
207 1420-9071
208 schema:name Cellular and Molecular Life Sciences
209 rdf:type schema:Periodical
210 sg:person.01050473225.52 schema:affiliation https://www.grid.ac/institutes/grid.48336.3a
211 schema:familyName Appella
212 schema:givenName E.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050473225.52
214 rdf:type schema:Person
215 sg:person.01050565740.93 schema:affiliation https://www.grid.ac/institutes/grid.24381.3c
216 schema:familyName Linder
217 schema:givenName S.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050565740.93
219 rdf:type schema:Person
220 sg:person.01103641055.71 schema:affiliation https://www.grid.ac/institutes/grid.24381.3c
221 schema:familyName Shoshan
222 schema:givenName M.
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103641055.71
224 rdf:type schema:Person
225 sg:person.01170031060.85 schema:affiliation https://www.grid.ac/institutes/grid.24381.3c
226 schema:familyName Kronenwett
227 schema:givenName U.
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170031060.85
229 rdf:type schema:Person
230 sg:person.01176606644.55 schema:affiliation https://www.grid.ac/institutes/grid.24381.3c
231 schema:familyName Alaiya
232 schema:givenName A. A.
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176606644.55
234 rdf:type schema:Person
235 sg:person.01211407472.30 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
236 schema:familyName Jörnvall
237 schema:givenName H.
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211407472.30
239 rdf:type schema:Person
240 sg:person.012455605442.40 schema:affiliation https://www.grid.ac/institutes/grid.48336.3a
241 schema:familyName Sakaguchi
242 schema:givenName K.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012455605442.40
244 rdf:type schema:Person
245 sg:person.01256046515.23 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
246 schema:familyName Bergman
247 schema:givenName A.-C.
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256046515.23
249 rdf:type schema:Person
250 sg:person.01314041754.28 schema:affiliation https://www.grid.ac/institutes/grid.24381.3c
251 schema:familyName Auer
252 schema:givenName G.
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314041754.28
254 rdf:type schema:Person
255 sg:person.0607361633.91 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
256 schema:familyName Bergman
257 schema:givenName T.
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607361633.91
259 rdf:type schema:Person
260 sg:person.0632061147.30 schema:affiliation https://www.grid.ac/institutes/grid.4444.0
261 schema:familyName Binetruy
262 schema:givenName B.
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632061147.30
264 rdf:type schema:Person
265 https://www.grid.ac/institutes/grid.24381.3c schema:alternateName Karolinska University Hospital
266 schema:name Radiumhemmet's Research Laboratory, Department of Oncology and Pathology, Karolinska Hospital, S-171 76 Stockholm (Sweden), SE
267 Unit of Cell and Molecular Analysis, Department of Oncology and Pathology, Karolinska Hospital, S-171 76 Stockholm (Sweden), SE
268 rdf:type schema:Organization
269 https://www.grid.ac/institutes/grid.4444.0 schema:alternateName French National Centre for Scientific Research
270 schema:name Department of Cancer Research, National Center of Scientific Research, F-94801 Villejuif (France), FR
271 rdf:type schema:Organization
272 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
273 schema:name Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 77 Stockholm (Sweden), SE
274 rdf:type schema:Organization
275 https://www.grid.ac/institutes/grid.48336.3a schema:alternateName National Cancer Institute
276 schema:name Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda (Maryland 20892, USA), US
277 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...