Mechanisms of p53-mediated apoptosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-01

AUTHORS

S. Bates, K. H. Vousden

ABSTRACT

. The loss of p53-mediated apoptosis (programmed cell death) has been implicated as an important event in tumour progression in a number of systems. p53 can induce or potentiate apoptosis through several mechanisms, both by regulating the expression of genes which can participate in the apoptotic response and through transcriptionally independent means. There appears to be cell type variability in both the response to p53 expression and in the requirement for p53 transcriptional transactivation for the induction of apoptosis. It seems clear, however, that the induction of p53 in untransformed cells is more likely to result in cell-cycle arrest, whereas the expression of p53 in their transformed counterparts is more likely to result in the induction of apoptosis, and this may, in part, reflect the deregulated expression of E2F-1 in tumour cells. The synergistic action of p53 and E2F-1 in the induction of apoptosis has raised the possibility that the reactivation of p53 in transformed cells can be an effective tumour therapy. More... »

PAGES

28-37

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s000180050267

DOI

http://dx.doi.org/10.1007/s000180050267

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016524853

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10065149


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Caspases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "E2F Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "E2F1 Transcription Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Models, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Tumor Necrosis Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Repressor Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retinoblastoma-Binding Protein 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Protein p53", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "fas Receptor", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "ABL Basic Research Program, NCI-FCRDC, Building 560, Room 22-96, West 7th Street, Frederick (Maryland 21702-1201, USA), Fax +1 301 846 1666, e-mail: vousden@ncifcrf.gov, US", 
          "id": "http://www.grid.ac/institutes/grid.418021.e", 
          "name": [
            "ABL Basic Research Program, NCI-FCRDC, Building 560, Room 22-96, West 7th Street, Frederick (Maryland 21702-1201, USA), Fax +1 301 846 1666, e-mail: vousden@ncifcrf.gov, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bates", 
        "givenName": "S.", 
        "id": "sg:person.0725600562.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725600562.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "ABL Basic Research Program, NCI-FCRDC, Building 560, Room 22-96, West 7th Street, Frederick (Maryland 21702-1201, USA), Fax +1 301 846 1666, e-mail: vousden@ncifcrf.gov, US", 
          "id": "http://www.grid.ac/institutes/grid.418021.e", 
          "name": [
            "ABL Basic Research Program, NCI-FCRDC, Building 560, Room 22-96, West 7th Street, Frederick (Maryland 21702-1201, USA), Fax +1 301 846 1666, e-mail: vousden@ncifcrf.gov, US"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vousden", 
        "givenName": "K. H.", 
        "id": "sg:person.01342746606.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342746606.50"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1999-01", 
    "datePublishedReg": "1999-01-01", 
    "description": "Abstract. The loss of p53-mediated apoptosis (programmed cell death) has been implicated as an important event in tumour progression in a number of systems. p53 can induce or potentiate apoptosis through several mechanisms, both by regulating the expression of genes which can participate in the apoptotic response and through transcriptionally independent means. There appears to be cell type variability in both the response to p53 expression and in the requirement for p53 transcriptional transactivation for the induction of apoptosis. It seems clear, however, that the induction of p53 in untransformed cells is more likely to result in cell-cycle arrest, whereas the expression of p53 in their transformed counterparts is more likely to result in the induction of apoptosis, and this may, in part, reflect the deregulated expression of E2F-1 in tumour cells. The synergistic action of p53 and E2F-1 in the induction of apoptosis has raised the possibility that the reactivation of p53 in transformed cells can be an effective tumour therapy.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s000180050267", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295005", 
        "issn": [
          "1420-682X", 
          "1420-9071"
        ], 
        "name": "Cellular and Molecular Life Sciences", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "keywords": [
      "induction of apoptosis", 
      "p53-mediated apoptosis", 
      "expression of p53", 
      "reactivation of p53", 
      "induction of p53", 
      "cell cycle arrest", 
      "p53 expression", 
      "tumor progression", 
      "E2F-1", 
      "tumor cells", 
      "p53", 
      "effective tumor therapy", 
      "apoptosis", 
      "expression of genes", 
      "tumor therapy", 
      "deregulated expression", 
      "induction", 
      "apoptotic response", 
      "cell-type variability", 
      "synergistic action", 
      "expression", 
      "cells", 
      "untransformed cells", 
      "therapy", 
      "progression", 
      "transcriptional transactivation", 
      "response", 
      "arrest", 
      "reactivation", 
      "important events", 
      "transactivation", 
      "mechanism", 
      "genes", 
      "action", 
      "events", 
      "loss", 
      "number", 
      "variability", 
      "counterparts", 
      "possibility", 
      "part", 
      "means", 
      "independent means", 
      "type variability", 
      "number of systems", 
      "system", 
      "requirements"
    ], 
    "name": "Mechanisms of p53-mediated apoptosis", 
    "pagination": "28-37", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1016524853"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s000180050267"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10065149"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s000180050267", 
      "https://app.dimensions.ai/details/publication/pub.1016524853"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T20:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_343.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s000180050267"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s000180050267'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s000180050267'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s000180050267'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s000180050267'


 

This table displays all metadata directly associated to this object as RDF triples.

183 TRIPLES      20 PREDICATES      90 URIs      82 LITERALS      24 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s000180050267 schema:about N27ce7f256f004d12afff53ddf22ec36d
2 N296271f3020a42b5a7663c8cf8242cc8
3 N3e0fbd6781b74a6892adc54c412d089d
4 N4218970bbf84440d995a6d73b13fc646
5 N425bf4ef745d4311abd9c364415e27bd
6 N47667a3cea6e49d0a8d21c26e1c0bc4f
7 N5ccdc38ae189430a9af56d8416ab969a
8 N683579bb58bb4521a9f9cfe3b057bb6f
9 N6eb88d05a39a4bd9bffdc84e1bc5855a
10 N732604198ec54de7baea7d0544d1ea81
11 N9af81767d19348968d7048606fa0362e
12 Na0222ac32882459ab867d389efdcf80f
13 Nd94c08f9f16545e88f0b817928e59f5f
14 Ne83bea5b49ce4313abafaa2cf697d958
15 Ne90fa35aadb5480ca07efdd6ef79838f
16 Neb4865fbf96840b48843f74888361c5f
17 Nec8427463f35405db8debd84852bca9b
18 anzsrc-for:06
19 anzsrc-for:0601
20 schema:author N252bb6dce7de4cca810a619575fb7e65
21 schema:datePublished 1999-01
22 schema:datePublishedReg 1999-01-01
23 schema:description Abstract. The loss of p53-mediated apoptosis (programmed cell death) has been implicated as an important event in tumour progression in a number of systems. p53 can induce or potentiate apoptosis through several mechanisms, both by regulating the expression of genes which can participate in the apoptotic response and through transcriptionally independent means. There appears to be cell type variability in both the response to p53 expression and in the requirement for p53 transcriptional transactivation for the induction of apoptosis. It seems clear, however, that the induction of p53 in untransformed cells is more likely to result in cell-cycle arrest, whereas the expression of p53 in their transformed counterparts is more likely to result in the induction of apoptosis, and this may, in part, reflect the deregulated expression of E2F-1 in tumour cells. The synergistic action of p53 and E2F-1 in the induction of apoptosis has raised the possibility that the reactivation of p53 in transformed cells can be an effective tumour therapy.
24 schema:genre article
25 schema:isAccessibleForFree false
26 schema:isPartOf N3140bd1fc18e4cc9a0773627d23ab72a
27 Nb107e00d03b740ec8043d7ebe0d879a2
28 sg:journal.1295005
29 schema:keywords E2F-1
30 action
31 apoptosis
32 apoptotic response
33 arrest
34 cell cycle arrest
35 cell-type variability
36 cells
37 counterparts
38 deregulated expression
39 effective tumor therapy
40 events
41 expression
42 expression of genes
43 expression of p53
44 genes
45 important events
46 independent means
47 induction
48 induction of apoptosis
49 induction of p53
50 loss
51 means
52 mechanism
53 number
54 number of systems
55 p53
56 p53 expression
57 p53-mediated apoptosis
58 part
59 possibility
60 progression
61 reactivation
62 reactivation of p53
63 requirements
64 response
65 synergistic action
66 system
67 therapy
68 transactivation
69 transcriptional transactivation
70 tumor cells
71 tumor progression
72 tumor therapy
73 type variability
74 untransformed cells
75 variability
76 schema:name Mechanisms of p53-mediated apoptosis
77 schema:pagination 28-37
78 schema:productId N0f3e4fdb76ac4888bc2a9450a5538f2d
79 N6732c11cb54042ce9f2a2f82000a8185
80 Nd1951371b021410794cd8f2f62e1d22f
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016524853
82 https://doi.org/10.1007/s000180050267
83 schema:sdDatePublished 2022-11-24T20:50
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher Nfe7932c1110848abb3425f83af9cea2f
86 schema:url https://doi.org/10.1007/s000180050267
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N0f3e4fdb76ac4888bc2a9450a5538f2d schema:name dimensions_id
91 schema:value pub.1016524853
92 rdf:type schema:PropertyValue
93 N252bb6dce7de4cca810a619575fb7e65 rdf:first sg:person.0725600562.35
94 rdf:rest N9e77dc76dda844d8a39a4317c5c2b257
95 N27ce7f256f004d12afff53ddf22ec36d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Apoptosis
97 rdf:type schema:DefinedTerm
98 N296271f3020a42b5a7663c8cf8242cc8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Retinoblastoma-Binding Protein 1
100 rdf:type schema:DefinedTerm
101 N3140bd1fc18e4cc9a0773627d23ab72a schema:issueNumber 1
102 rdf:type schema:PublicationIssue
103 N3e0fbd6781b74a6892adc54c412d089d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Tumor Suppressor Protein p53
105 rdf:type schema:DefinedTerm
106 N4218970bbf84440d995a6d73b13fc646 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Cell Cycle Proteins
108 rdf:type schema:DefinedTerm
109 N425bf4ef745d4311abd9c364415e27bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Caspases
111 rdf:type schema:DefinedTerm
112 N47667a3cea6e49d0a8d21c26e1c0bc4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name E2F Transcription Factors
114 rdf:type schema:DefinedTerm
115 N5ccdc38ae189430a9af56d8416ab969a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Receptors, Tumor Necrosis Factor
117 rdf:type schema:DefinedTerm
118 N6732c11cb54042ce9f2a2f82000a8185 schema:name doi
119 schema:value 10.1007/s000180050267
120 rdf:type schema:PropertyValue
121 N683579bb58bb4521a9f9cfe3b057bb6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Carrier Proteins
123 rdf:type schema:DefinedTerm
124 N6eb88d05a39a4bd9bffdc84e1bc5855a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Transcription Factors
126 rdf:type schema:DefinedTerm
127 N732604198ec54de7baea7d0544d1ea81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name fas Receptor
129 rdf:type schema:DefinedTerm
130 N9af81767d19348968d7048606fa0362e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name DNA-Binding Proteins
132 rdf:type schema:DefinedTerm
133 N9e77dc76dda844d8a39a4317c5c2b257 rdf:first sg:person.01342746606.50
134 rdf:rest rdf:nil
135 Na0222ac32882459ab867d389efdcf80f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name E2F1 Transcription Factor
137 rdf:type schema:DefinedTerm
138 Nb107e00d03b740ec8043d7ebe0d879a2 schema:volumeNumber 55
139 rdf:type schema:PublicationVolume
140 Nd1951371b021410794cd8f2f62e1d22f schema:name pubmed_id
141 schema:value 10065149
142 rdf:type schema:PropertyValue
143 Nd94c08f9f16545e88f0b817928e59f5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Mitochondria
145 rdf:type schema:DefinedTerm
146 Ne83bea5b49ce4313abafaa2cf697d958 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Repressor Proteins
148 rdf:type schema:DefinedTerm
149 Ne90fa35aadb5480ca07efdd6ef79838f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Models, Genetic
151 rdf:type schema:DefinedTerm
152 Neb4865fbf96840b48843f74888361c5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Transcription, Genetic
154 rdf:type schema:DefinedTerm
155 Nec8427463f35405db8debd84852bca9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Gene Expression Regulation
157 rdf:type schema:DefinedTerm
158 Nfe7932c1110848abb3425f83af9cea2f schema:name Springer Nature - SN SciGraph project
159 rdf:type schema:Organization
160 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
161 schema:name Biological Sciences
162 rdf:type schema:DefinedTerm
163 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
164 schema:name Biochemistry and Cell Biology
165 rdf:type schema:DefinedTerm
166 sg:journal.1295005 schema:issn 1420-682X
167 1420-9071
168 schema:name Cellular and Molecular Life Sciences
169 schema:publisher Springer Nature
170 rdf:type schema:Periodical
171 sg:person.01342746606.50 schema:affiliation grid-institutes:grid.418021.e
172 schema:familyName Vousden
173 schema:givenName K. H.
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01342746606.50
175 rdf:type schema:Person
176 sg:person.0725600562.35 schema:affiliation grid-institutes:grid.418021.e
177 schema:familyName Bates
178 schema:givenName S.
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725600562.35
180 rdf:type schema:Person
181 grid-institutes:grid.418021.e schema:alternateName ABL Basic Research Program, NCI-FCRDC, Building 560, Room 22-96, West 7th Street, Frederick (Maryland 21702-1201, USA), Fax +1 301 846 1666, e-mail: vousden@ncifcrf.gov, US
182 schema:name ABL Basic Research Program, NCI-FCRDC, Building 560, Room 22-96, West 7th Street, Frederick (Maryland 21702-1201, USA), Fax +1 301 846 1666, e-mail: vousden@ncifcrf.gov, US
183 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...