Ascorbate inducible N259 glycans on prolyl 4-hydroxylase subunit α1 promote hydroxylation and secretion of type I collagen View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-27

AUTHORS

Run Shi, Weimin Hu, Yan Zhang, Shanshan Gao, Andrew H. Smith, Jun Ye, Lili Cai, Linda M. Graham, Chaoyang Li

ABSTRACT

Ascorbic acid (vitamin C, VC) increases the secretion of mature collagen by promoting the activity of prolyl 4-hydroxylase subunit α 1 (P4HA1). To explore the mechanism involved, we investigated the role of N-linked glycosylation, which can regulate enzyme activity. P4HA1 has two glycosylation sites, Asn (N) 113 and N259. Our studies show that glycosylation of N259, but not N113, by STT3B and magnesium transporter 1 (MAGT1) is augmented by VC. N259 glycosylation on P4HA1 correlates with enhanced pepsin-resistant collagen 1α2 secretion. Downregulation of Stt3b and Magt1 reduces N259 glycans on P4HA1. In collagen 1α2 purified from Stt3b-silenced fibroblasts, decreased hydroxylation is found at five specific proline residues, while significantly increased hydroxylation is noted at two proline residues. Similarly, in collagen 1α1, reduced proline hydroxylation is detected at eight sites and increased proline hydroxylation is found at four sites. These results suggest that N-linked glycosylation of P4HA1 can direct hydroxylation at specific proline residues and affect collagen maturation. More... »

PAGES

1-16

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-019-03081-w

DOI

http://dx.doi.org/10.1007/s00018-019-03081-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113046421

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30919021


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Guangzhou Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410737.6", 
          "name": [
            "State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 44 Xiao Hong Shan Zhong Qu, 430071, Wuhan, Hubei, China", 
            "University of Chinese Academy of Sciences, Beijing, China", 
            "Affiliated Cancer Hospital and Institute of Guangzhou Medical University, 78 Heng Zhi Gang Road, 510095, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shi", 
        "givenName": "Run", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410737.6", 
          "name": [
            "Affiliated Cancer Hospital and Institute of Guangzhou Medical University, 78 Heng Zhi Gang Road, 510095, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Weimin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wuhan Institute Of Virology", 
          "id": "https://www.grid.ac/institutes/grid.439104.b", 
          "name": [
            "State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 44 Xiao Hong Shan Zhong Qu, 430071, Wuhan, Hubei, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Yan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wuhan Institute Of Virology", 
          "id": "https://www.grid.ac/institutes/grid.439104.b", 
          "name": [
            "State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 44 Xiao Hong Shan Zhong Qu, 430071, Wuhan, Hubei, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gao", 
        "givenName": "Shanshan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH, USA", 
            "Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Andrew H.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Akron", 
          "id": "https://www.grid.ac/institutes/grid.265881.0", 
          "name": [
            "Department of Statistics, University of Akron, Akron, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ye", 
        "givenName": "Jun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wuhan Institute Of Virology", 
          "id": "https://www.grid.ac/institutes/grid.439104.b", 
          "name": [
            "State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 44 Xiao Hong Shan Zhong Qu, 430071, Wuhan, Hubei, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cai", 
        "givenName": "Lili", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cleveland Clinic", 
          "id": "https://www.grid.ac/institutes/grid.239578.2", 
          "name": [
            "Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH, USA", 
            "Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Graham", 
        "givenName": "Linda M.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Guangzhou Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410737.6", 
          "name": [
            "State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 44 Xiao Hong Shan Zhong Qu, 430071, Wuhan, Hubei, China", 
            "Affiliated Cancer Hospital and Institute of Guangzhou Medical University, 78 Heng Zhi Gang Road, 510095, Guangzhou, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Chaoyang", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.86.12.4392", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006933897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.11.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009783669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(03)00243-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009882109"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(81)91830-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010161790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12523660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010681747", 
          "https://doi.org/10.1111/1523-1747.ep12523660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/1523-1747.ep12523660", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010681747"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/07853890109002055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014828186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2795(72)90023-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016381359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2795(72)90023-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016381359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m109.094607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019302924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2016.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019466735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2016.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019466735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2016.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019466735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cellsig.2016.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019466735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.64.070195.002155", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020106187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.272.28.17342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023036405"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2744(80)90040-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029264546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2744(80)90040-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029264546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1977.tb11888.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029658849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2744(80)90041-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030849265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2744(80)90041-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030849265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1235681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034393517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1235681", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034393517"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.17.9926", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034438898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bmc.2009.02.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040149781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(78)91010-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041817730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m112.442939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042773790"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1977.tb11889.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044053621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep20946", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045170481", 
          "https://doi.org/10.1038/srep20946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/9780470122860.ch6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045187619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m306806200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051463236"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0945-053x(01)00130-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052107189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00342a040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055171081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00342a041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055171082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/54.6.1135s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077344891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079518084", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082584101", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-03-27", 
    "datePublishedReg": "2019-03-27", 
    "description": "Ascorbic acid (vitamin C, VC) increases the secretion of mature collagen by promoting the activity of prolyl 4-hydroxylase subunit \u03b1 1 (P4HA1). To explore the mechanism involved, we investigated the role of N-linked glycosylation, which can regulate enzyme activity. P4HA1 has two glycosylation sites, Asn (N) 113 and N259. Our studies show that glycosylation of N259, but not N113, by STT3B and magnesium transporter 1 (MAGT1) is augmented by VC. N259 glycosylation on P4HA1 correlates with enhanced pepsin-resistant collagen 1\u03b12 secretion. Downregulation of Stt3b and Magt1 reduces N259 glycans on P4HA1. In collagen 1\u03b12 purified from Stt3b-silenced fibroblasts, decreased hydroxylation is found at five specific proline residues, while significantly increased hydroxylation is noted at two proline residues. Similarly, in collagen 1\u03b11, reduced proline hydroxylation is detected at eight sites and increased proline hydroxylation is found at four sites. These results suggest that N-linked glycosylation of P4HA1 can direct hydroxylation at specific proline residues and affect collagen maturation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00018-019-03081-w", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2533051", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295005", 
        "issn": [
          "1420-682X", 
          "1420-9071"
        ], 
        "name": "Cellular and Molecular Life Sciences", 
        "type": "Periodical"
      }
    ], 
    "name": "Ascorbate inducible N259 glycans on prolyl 4-hydroxylase subunit \u03b11 promote hydroxylation and secretion of type I collagen", 
    "pagination": "1-16", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00018-019-03081-w"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113046421"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a3cd6a10465b891d520055cf078a04854f26833cc5377e62a6f5c525e6360f99"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9705402"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30919021"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00018-019-03081-w", 
      "https://app.dimensions.ai/details/publication/pub.1113046421"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-16T06:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106837_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00018-019-03081-w"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00018-019-03081-w'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00018-019-03081-w'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00018-019-03081-w'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00018-019-03081-w'


 

This table displays all metadata directly associated to this object as RDF triples.

214 TRIPLES      21 PREDICATES      56 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00018-019-03081-w schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N1806851ef2bc4d62bf2e9865aaa67b8d
4 schema:citation sg:pub.10.1038/srep20946
5 sg:pub.10.1111/1523-1747.ep12523660
6 https://app.dimensions.ai/details/publication/pub.1079518084
7 https://app.dimensions.ai/details/publication/pub.1082584101
8 https://doi.org/10.1002/9780470122860.ch6
9 https://doi.org/10.1016/0005-2744(80)90040-6
10 https://doi.org/10.1016/0005-2744(80)90041-8
11 https://doi.org/10.1016/0005-2795(72)90023-2
12 https://doi.org/10.1016/0006-291x(78)91010-0
13 https://doi.org/10.1016/0006-291x(81)91830-1
14 https://doi.org/10.1016/j.bmc.2009.02.037
15 https://doi.org/10.1016/j.cell.2008.11.047
16 https://doi.org/10.1016/j.cellsig.2016.03.010
17 https://doi.org/10.1016/s0945-053x(01)00130-5
18 https://doi.org/10.1016/s1097-2765(03)00243-0
19 https://doi.org/10.1021/bi00342a040
20 https://doi.org/10.1021/bi00342a041
21 https://doi.org/10.1073/pnas.86.12.4392
22 https://doi.org/10.1074/jbc.270.17.9926
23 https://doi.org/10.1074/jbc.272.28.17342
24 https://doi.org/10.1074/jbc.m109.094607
25 https://doi.org/10.1074/jbc.m112.442939
26 https://doi.org/10.1074/jbc.m306806200
27 https://doi.org/10.1093/ajcn/54.6.1135s
28 https://doi.org/10.1111/1523-1747.ep12523660
29 https://doi.org/10.1111/j.1432-1033.1977.tb11888.x
30 https://doi.org/10.1111/j.1432-1033.1977.tb11889.x
31 https://doi.org/10.1126/science.1235681
32 https://doi.org/10.1146/annurev.bi.64.070195.002155
33 https://doi.org/10.3109/07853890109002055
34 schema:datePublished 2019-03-27
35 schema:datePublishedReg 2019-03-27
36 schema:description Ascorbic acid (vitamin C, VC) increases the secretion of mature collagen by promoting the activity of prolyl 4-hydroxylase subunit α 1 (P4HA1). To explore the mechanism involved, we investigated the role of N-linked glycosylation, which can regulate enzyme activity. P4HA1 has two glycosylation sites, Asn (N) 113 and N259. Our studies show that glycosylation of N259, but not N113, by STT3B and magnesium transporter 1 (MAGT1) is augmented by VC. N259 glycosylation on P4HA1 correlates with enhanced pepsin-resistant collagen 1α2 secretion. Downregulation of Stt3b and Magt1 reduces N259 glycans on P4HA1. In collagen 1α2 purified from Stt3b-silenced fibroblasts, decreased hydroxylation is found at five specific proline residues, while significantly increased hydroxylation is noted at two proline residues. Similarly, in collagen 1α1, reduced proline hydroxylation is detected at eight sites and increased proline hydroxylation is found at four sites. These results suggest that N-linked glycosylation of P4HA1 can direct hydroxylation at specific proline residues and affect collagen maturation.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree false
40 schema:isPartOf sg:journal.1295005
41 schema:name Ascorbate inducible N259 glycans on prolyl 4-hydroxylase subunit α1 promote hydroxylation and secretion of type I collagen
42 schema:pagination 1-16
43 schema:productId N2451d312ac6d427b866675d53a63cb54
44 N2a3e4cd7920d47d6abda1f0c7ad78217
45 N986e56fd285c4c7598ee25ca3976692a
46 Na6a57d6f3e6a408fb38e1121e754251b
47 Nce5c3b9d47184d00afe6033b122e2c8d
48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113046421
49 https://doi.org/10.1007/s00018-019-03081-w
50 schema:sdDatePublished 2019-04-16T06:25
51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
52 schema:sdPublisher N4a6f5003464c4d0caf76c55748252018
53 schema:url https://link.springer.com/10.1007%2Fs00018-019-03081-w
54 sgo:license sg:explorer/license/
55 sgo:sdDataset articles
56 rdf:type schema:ScholarlyArticle
57 N0e704f6c535e4b008698089c5b718e9b rdf:first N5453dc94947f482a8a442eca4f2543ff
58 rdf:rest N17d6f90f35c84a89825d985cde6646b1
59 N17d6f90f35c84a89825d985cde6646b1 rdf:first N75c187757f99463291ffdc8fc5e3a5c4
60 rdf:rest Nc554f06a27c5460b8a061c0145670128
61 N1806851ef2bc4d62bf2e9865aaa67b8d rdf:first Neb8ca86b60534227b3ca1f2ace41625d
62 rdf:rest Nb966d371c9be41948a49cac17e0f19cb
63 N2451d312ac6d427b866675d53a63cb54 schema:name nlm_unique_id
64 schema:value 9705402
65 rdf:type schema:PropertyValue
66 N2a3e4cd7920d47d6abda1f0c7ad78217 schema:name pubmed_id
67 schema:value 30919021
68 rdf:type schema:PropertyValue
69 N303fb77e9bfb43c58e8cdef2ba7c8c40 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
70 schema:familyName Graham
71 schema:givenName Linda M.
72 rdf:type schema:Person
73 N34ee450544184561a96e7791529e6b72 rdf:first N681ae61e6ea445b6851b6ea3ede2258a
74 rdf:rest rdf:nil
75 N42ee64efe52645d0bca11337930dc2aa schema:affiliation https://www.grid.ac/institutes/grid.439104.b
76 schema:familyName Gao
77 schema:givenName Shanshan
78 rdf:type schema:Person
79 N4a6f5003464c4d0caf76c55748252018 schema:name Springer Nature - SN SciGraph project
80 rdf:type schema:Organization
81 N5453dc94947f482a8a442eca4f2543ff schema:affiliation https://www.grid.ac/institutes/grid.265881.0
82 schema:familyName Ye
83 schema:givenName Jun
84 rdf:type schema:Person
85 N681ae61e6ea445b6851b6ea3ede2258a schema:affiliation https://www.grid.ac/institutes/grid.410737.6
86 schema:familyName Li
87 schema:givenName Chaoyang
88 rdf:type schema:Person
89 N6e56efd374a14b76856902c07962aeae schema:affiliation https://www.grid.ac/institutes/grid.439104.b
90 schema:familyName Zhang
91 schema:givenName Yan
92 rdf:type schema:Person
93 N75c187757f99463291ffdc8fc5e3a5c4 schema:affiliation https://www.grid.ac/institutes/grid.439104.b
94 schema:familyName Cai
95 schema:givenName Lili
96 rdf:type schema:Person
97 N87e0e5ceaaf24840b0ec767df1bdd6b0 schema:affiliation https://www.grid.ac/institutes/grid.410737.6
98 schema:familyName Hu
99 schema:givenName Weimin
100 rdf:type schema:Person
101 N96360d26542b4fe6afeb86793884eb24 rdf:first N6e56efd374a14b76856902c07962aeae
102 rdf:rest Naf29258fa34e4eb7bd09db069d4d0251
103 N986e56fd285c4c7598ee25ca3976692a schema:name dimensions_id
104 schema:value pub.1113046421
105 rdf:type schema:PropertyValue
106 Na6a57d6f3e6a408fb38e1121e754251b schema:name doi
107 schema:value 10.1007/s00018-019-03081-w
108 rdf:type schema:PropertyValue
109 Nad5250d3299247e88563a4ca4f69649b rdf:first Nc1b917cb490347ce9f04e4e036bb28d3
110 rdf:rest N0e704f6c535e4b008698089c5b718e9b
111 Naf29258fa34e4eb7bd09db069d4d0251 rdf:first N42ee64efe52645d0bca11337930dc2aa
112 rdf:rest Nad5250d3299247e88563a4ca4f69649b
113 Nb966d371c9be41948a49cac17e0f19cb rdf:first N87e0e5ceaaf24840b0ec767df1bdd6b0
114 rdf:rest N96360d26542b4fe6afeb86793884eb24
115 Nc1b917cb490347ce9f04e4e036bb28d3 schema:affiliation https://www.grid.ac/institutes/grid.239578.2
116 schema:familyName Smith
117 schema:givenName Andrew H.
118 rdf:type schema:Person
119 Nc554f06a27c5460b8a061c0145670128 rdf:first N303fb77e9bfb43c58e8cdef2ba7c8c40
120 rdf:rest N34ee450544184561a96e7791529e6b72
121 Nce5c3b9d47184d00afe6033b122e2c8d schema:name readcube_id
122 schema:value a3cd6a10465b891d520055cf078a04854f26833cc5377e62a6f5c525e6360f99
123 rdf:type schema:PropertyValue
124 Neb8ca86b60534227b3ca1f2ace41625d schema:affiliation https://www.grid.ac/institutes/grid.410737.6
125 schema:familyName Shi
126 schema:givenName Run
127 rdf:type schema:Person
128 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
129 schema:name Biological Sciences
130 rdf:type schema:DefinedTerm
131 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
132 schema:name Biochemistry and Cell Biology
133 rdf:type schema:DefinedTerm
134 sg:grant.2533051 http://pending.schema.org/fundedItem sg:pub.10.1007/s00018-019-03081-w
135 rdf:type schema:MonetaryGrant
136 sg:journal.1295005 schema:issn 1420-682X
137 1420-9071
138 schema:name Cellular and Molecular Life Sciences
139 rdf:type schema:Periodical
140 sg:pub.10.1038/srep20946 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045170481
141 https://doi.org/10.1038/srep20946
142 rdf:type schema:CreativeWork
143 sg:pub.10.1111/1523-1747.ep12523660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010681747
144 https://doi.org/10.1111/1523-1747.ep12523660
145 rdf:type schema:CreativeWork
146 https://app.dimensions.ai/details/publication/pub.1079518084 schema:CreativeWork
147 https://app.dimensions.ai/details/publication/pub.1082584101 schema:CreativeWork
148 https://doi.org/10.1002/9780470122860.ch6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045187619
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1016/0005-2744(80)90040-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029264546
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1016/0005-2744(80)90041-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030849265
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1016/0005-2795(72)90023-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016381359
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1016/0006-291x(78)91010-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041817730
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/0006-291x(81)91830-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010161790
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/j.bmc.2009.02.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040149781
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.cell.2008.11.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009783669
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.cellsig.2016.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019466735
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/s0945-053x(01)00130-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052107189
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/s1097-2765(03)00243-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009882109
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1021/bi00342a040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055171081
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1021/bi00342a041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055171082
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1073/pnas.86.12.4392 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006933897
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1074/jbc.270.17.9926 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034438898
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1074/jbc.272.28.17342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023036405
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1074/jbc.m109.094607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019302924
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1074/jbc.m112.442939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042773790
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1074/jbc.m306806200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051463236
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1093/ajcn/54.6.1135s schema:sameAs https://app.dimensions.ai/details/publication/pub.1077344891
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1111/1523-1747.ep12523660 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010681747
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1111/j.1432-1033.1977.tb11888.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029658849
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1111/j.1432-1033.1977.tb11889.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044053621
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1126/science.1235681 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034393517
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1146/annurev.bi.64.070195.002155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020106187
197 rdf:type schema:CreativeWork
198 https://doi.org/10.3109/07853890109002055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014828186
199 rdf:type schema:CreativeWork
200 https://www.grid.ac/institutes/grid.239578.2 schema:alternateName Cleveland Clinic
201 schema:name Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH, USA
202 Department of Vascular Surgery, Cleveland Clinic, Cleveland, OH, USA
203 rdf:type schema:Organization
204 https://www.grid.ac/institutes/grid.265881.0 schema:alternateName University of Akron
205 schema:name Department of Statistics, University of Akron, Akron, OH, USA
206 rdf:type schema:Organization
207 https://www.grid.ac/institutes/grid.410737.6 schema:alternateName Guangzhou Medical University
208 schema:name Affiliated Cancer Hospital and Institute of Guangzhou Medical University, 78 Heng Zhi Gang Road, 510095, Guangzhou, China
209 State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 44 Xiao Hong Shan Zhong Qu, 430071, Wuhan, Hubei, China
210 University of Chinese Academy of Sciences, Beijing, China
211 rdf:type schema:Organization
212 https://www.grid.ac/institutes/grid.439104.b schema:alternateName Wuhan Institute Of Virology
213 schema:name State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 44 Xiao Hong Shan Zhong Qu, 430071, Wuhan, Hubei, China
214 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...