Transition of inner cell mass to embryonic stem cells: mechanisms, facts, and hypotheses View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03

AUTHORS

Seyedeh-Nafiseh Hassani, Sharif Moradi, Sara Taleahmad, Thomas Braun, Hossein Baharvand

ABSTRACT

Embryonic stem cells (ESCs) are immortal stem cells that own multi-lineage differentiation potential. ESCs are commonly derived from the inner cell mass (ICM) of pre-implantation embryos. Due to their tremendous developmental capacity and unlimited self-renewal, ESCs have diverse biomedical applications. Different culture media have been developed to procure and maintain ESCs in a state of naïve pluripotency, and to preserve a stable genome and epigenome during serial passaging. Chromatin modifications such as DNA methylation and histone modifications along with microRNA activity and different signaling pathways dynamically contribute to the regulation of the ESC gene regulatory network (GRN). Such modifications undergo remarkable changes in different ESC media and determine the quality and developmental potential of ESCs. In this review, we discuss the current approaches for derivation and maintenance of ESCs, and examine how differences in culture media impact on the characteristics of pluripotency via modulation of GRN during the course of ICM outgrowth into ESCs. We also summarize the current hypotheses concerning the origin of ESCs and provide a perspective about the relationship of these cells to their in vivo counterparts (early embryonic cells around the time of implantation). Finally, we discuss generation of ESCs from human embryos and domesticated animals, and offer suggestions to further advance this fascinating field. More... »

PAGES

873-892

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00018-018-2965-y

    DOI

    http://dx.doi.org/10.1007/s00018-018-2965-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1109816001

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30420999


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