Melatonin, mitochondria, and the skin View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-08-12

AUTHORS

Andrzej T. Slominski, Michal A. Zmijewski, Igor Semak, Tae-Kang Kim, Zorica Janjetovic, Radomir M. Slominski, Jaroslaw W. Zmijewski

ABSTRACT

The skin being a protective barrier between external and internal (body) environments has the sensory and adaptive capacity to maintain local and global body homeostasis in response to noxious factors. An important part of the skin response to stress is its ability for melatonin synthesis and subsequent metabolism through the indolic and kynuric pathways. Indeed, melatonin and its metabolites have emerged as indispensable for physiological skin functions and for effective protection of a cutaneous homeostasis from hostile environmental factors. Moreover, they attenuate the pathological processes including carcinogenesis and other hyperproliferative/inflammatory conditions. Interestingly, mitochondria appear to be a central hub of melatonin metabolism in the skin cells. Furthermore, substantial evidence has accumulated on the protective role of the melatonin against ultraviolet radiation and the attendant mitochondrial dysfunction. Melatonin and its metabolites appear to have a modulatory impact on mitochondrion redox and bioenergetic homeostasis, as well as the anti-apoptotic effects. Of note, some metabolites exhibit even greater impact than melatonin alone. Herein, we emphasize that melatonin–mitochondria axis would control integumental functions designed to protect local and perhaps global homeostasis. Given the phylogenetic origin and primordial actions of melatonin, we propose that the melatonin-related mitochondrial functions represent an evolutionary conserved mechanism involved in cellular adaptive response to skin injury and repair. More... »

PAGES

3913-3925

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-017-2617-7

DOI

http://dx.doi.org/10.1007/s00018-017-2617-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091200015

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28803347


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antioxidants", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melatonin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin Physiological Phenomena", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "VA Medical Center, Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.280808.a", 
          "name": [
            "Department of Dermatology, Comprehensive Cancer Center Cancer Chemoprevention Program, University of Alabama at Birmingham, 35294, Birmingham, AL, USA", 
            "VA Medical Center, Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Slominski", 
        "givenName": "Andrzej T.", 
        "id": "sg:person.016612034677.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016612034677.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Histology, Medical University of Gda\u0144sk, Gda\u0144sk, Poland", 
          "id": "http://www.grid.ac/institutes/grid.11451.30", 
          "name": [
            "Department of Histology, Medical University of Gda\u0144sk, Gda\u0144sk, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zmijewski", 
        "givenName": "Michal A.", 
        "id": "sg:person.01357647717.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357647717.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biochemistry, Belarusian State University, Minsk, Belarus", 
          "id": "http://www.grid.ac/institutes/grid.17678.3f", 
          "name": [
            "Department of Biochemistry, Belarusian State University, Minsk, Belarus"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Semak", 
        "givenName": "Igor", 
        "id": "sg:person.01312653663.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312653663.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Comprehensive Cancer Center Cancer Chemoprevention Program, University of Alabama at Birmingham, 35294, Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Dermatology, Comprehensive Cancer Center Cancer Chemoprevention Program, University of Alabama at Birmingham, 35294, Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Tae-Kang", 
        "id": "sg:person.01122406003.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122406003.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Comprehensive Cancer Center Cancer Chemoprevention Program, University of Alabama at Birmingham, 35294, Birmingham, AL, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Department of Dermatology, Comprehensive Cancer Center Cancer Chemoprevention Program, University of Alabama at Birmingham, 35294, Birmingham, AL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Janjetovic", 
        "givenName": "Zorica", 
        "id": "sg:person.0576400136.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576400136.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA", 
          "id": "http://www.grid.ac/institutes/grid.267301.1", 
          "name": [
            "Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Slominski", 
        "givenName": "Radomir M.", 
        "id": "sg:person.01103054167.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103054167.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, USA", 
          "id": "http://www.grid.ac/institutes/grid.265892.2", 
          "name": [
            "Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zmijewski", 
        "givenName": "Jaroslaw W.", 
        "id": "sg:person.01202776532.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202776532.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/s41598-017-01305-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085081257", 
          "https://doi.org/10.1038/s41598-017-01305-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1743-7075-2-22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007812417", 
          "https://doi.org/10.1186/1743-7075-2-22"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-19683-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029201023", 
          "https://doi.org/10.1007/978-3-642-19683-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206301", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008559287", 
          "https://doi.org/10.1038/sj.onc.1206301"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004030050258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005201623", 
          "https://doi.org/10.1007/s004030050258"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00281-007-0060-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027640334", 
          "https://doi.org/10.1007/s00281-007-0060-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nchembio727", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043245379", 
          "https://doi.org/10.1038/nchembio727"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00774-009-0153-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017753540", 
          "https://doi.org/10.1007/s00774-009-0153-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/1831821a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016124256", 
          "https://doi.org/10.1038/1831821a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10863-013-9534-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008462846", 
          "https://doi.org/10.1007/s10863-013-9534-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02505248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021419999", 
          "https://doi.org/10.1007/bf02505248"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2017-08-12", 
    "datePublishedReg": "2017-08-12", 
    "description": "The skin being a protective barrier between external and internal (body) environments has the sensory and adaptive capacity to maintain local and global body homeostasis in response to noxious factors. An important part of the skin response to stress is its ability for melatonin synthesis and subsequent metabolism through the indolic and kynuric pathways. Indeed, melatonin and its metabolites have emerged as indispensable for physiological skin functions and for effective protection of a cutaneous homeostasis from hostile environmental factors. Moreover, they attenuate the pathological processes including carcinogenesis and other hyperproliferative/inflammatory conditions. Interestingly, mitochondria appear to be a central hub of melatonin metabolism in the skin cells. Furthermore, substantial evidence has accumulated on the protective role of the melatonin against ultraviolet radiation and the attendant mitochondrial dysfunction. Melatonin and its metabolites appear to have a modulatory impact on mitochondrion redox and bioenergetic homeostasis, as well as the anti-apoptotic effects. Of note, some metabolites exhibit even greater impact than melatonin alone. Herein, we emphasize that melatonin\u2013mitochondria axis would control integumental functions designed to protect local and perhaps global homeostasis. Given the phylogenetic origin and primordial actions of melatonin, we propose that the melatonin-related mitochondrial functions represent an evolutionary conserved mechanism involved in cellular adaptive response to skin injury and repair.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00018-017-2617-7", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.7028403", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2465059", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2543249", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295005", 
        "issn": [
          "1420-682X", 
          "1420-9071"
        ], 
        "name": "Cellular and Molecular Life Sciences", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "21", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "74"
      }
    ], 
    "keywords": [
      "cellular adaptive response", 
      "phylogenetic origin", 
      "bioenergetic homeostasis", 
      "kynuric pathways", 
      "physiological skin functions", 
      "mitochondrial function", 
      "anti-apoptotic effects", 
      "mitochondrial dysfunction", 
      "global homeostasis", 
      "adaptive response", 
      "homeostasis", 
      "hostile environmental factors", 
      "central hub", 
      "body homeostasis", 
      "mitochondria", 
      "cutaneous homeostasis", 
      "pathological processes", 
      "environmental factors", 
      "skin cells", 
      "melatonin synthesis", 
      "subsequent metabolism", 
      "skin function", 
      "melatonin metabolism", 
      "metabolism", 
      "metabolites", 
      "protective barrier", 
      "adaptive capacity", 
      "pathway", 
      "ultraviolet radiation", 
      "protective role", 
      "noxious factors", 
      "function", 
      "melatonin", 
      "response", 
      "substantial evidence", 
      "modulatory impact", 
      "cells", 
      "internal environment", 
      "redox", 
      "carcinogenesis", 
      "effective protection", 
      "mechanism", 
      "repair", 
      "role", 
      "stress", 
      "hub", 
      "factors", 
      "origin", 
      "inflammatory conditions", 
      "ability", 
      "synthesis", 
      "skin injury", 
      "evidence", 
      "great impact", 
      "environment", 
      "action", 
      "protection", 
      "Herein", 
      "skin", 
      "skin response", 
      "axis", 
      "impact", 
      "important part", 
      "process", 
      "capacity", 
      "conditions", 
      "part", 
      "dysfunction", 
      "effect", 
      "radiation", 
      "injury", 
      "barriers", 
      "note"
    ], 
    "name": "Melatonin, mitochondria, and the skin", 
    "pagination": "3913-3925", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1091200015"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00018-017-2617-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "28803347"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00018-017-2617-7", 
      "https://app.dimensions.ai/details/publication/pub.1091200015"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:02", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_748.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00018-017-2617-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00018-017-2617-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00018-017-2617-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00018-017-2617-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00018-017-2617-7'


 

This table displays all metadata directly associated to this object as RDF triples.

269 TRIPLES      21 PREDICATES      116 URIs      97 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00018-017-2617-7 schema:about N4b6dcc69bbd34df7b30094e78845a50f
2 N4f0486b6b4df4f9ea23ab9251e01c084
3 N719d55d96a3343718190d9a44405edb1
4 N775218d9f1904225b953da70b2efad89
5 N886b590f387e4a4dbdb9613c16291738
6 Na620d49575d546fe8686cbfe080cc0d2
7 Nc4a67c16031f4f30b58c08722bd0e939
8 anzsrc-for:06
9 anzsrc-for:0601
10 schema:author Nc79f88bb749c4d208a2f0fb3715458f9
11 schema:citation sg:pub.10.1007/978-3-642-19683-6
12 sg:pub.10.1007/bf02505248
13 sg:pub.10.1007/s00281-007-0060-9
14 sg:pub.10.1007/s004030050258
15 sg:pub.10.1007/s00774-009-0153-8
16 sg:pub.10.1007/s10863-013-9534-8
17 sg:pub.10.1038/1831821a0
18 sg:pub.10.1038/nchembio727
19 sg:pub.10.1038/s41598-017-01305-2
20 sg:pub.10.1038/sj.onc.1206301
21 sg:pub.10.1186/1743-7075-2-22
22 schema:datePublished 2017-08-12
23 schema:datePublishedReg 2017-08-12
24 schema:description The skin being a protective barrier between external and internal (body) environments has the sensory and adaptive capacity to maintain local and global body homeostasis in response to noxious factors. An important part of the skin response to stress is its ability for melatonin synthesis and subsequent metabolism through the indolic and kynuric pathways. Indeed, melatonin and its metabolites have emerged as indispensable for physiological skin functions and for effective protection of a cutaneous homeostasis from hostile environmental factors. Moreover, they attenuate the pathological processes including carcinogenesis and other hyperproliferative/inflammatory conditions. Interestingly, mitochondria appear to be a central hub of melatonin metabolism in the skin cells. Furthermore, substantial evidence has accumulated on the protective role of the melatonin against ultraviolet radiation and the attendant mitochondrial dysfunction. Melatonin and its metabolites appear to have a modulatory impact on mitochondrion redox and bioenergetic homeostasis, as well as the anti-apoptotic effects. Of note, some metabolites exhibit even greater impact than melatonin alone. Herein, we emphasize that melatonin–mitochondria axis would control integumental functions designed to protect local and perhaps global homeostasis. Given the phylogenetic origin and primordial actions of melatonin, we propose that the melatonin-related mitochondrial functions represent an evolutionary conserved mechanism involved in cellular adaptive response to skin injury and repair.
25 schema:genre article
26 schema:isAccessibleForFree true
27 schema:isPartOf N250240da6cd9453f9b3ac898d40c1975
28 N572fc59ccea040d4a0485e6e1cc3099e
29 sg:journal.1295005
30 schema:keywords Herein
31 ability
32 action
33 adaptive capacity
34 adaptive response
35 anti-apoptotic effects
36 axis
37 barriers
38 bioenergetic homeostasis
39 body homeostasis
40 capacity
41 carcinogenesis
42 cells
43 cellular adaptive response
44 central hub
45 conditions
46 cutaneous homeostasis
47 dysfunction
48 effect
49 effective protection
50 environment
51 environmental factors
52 evidence
53 factors
54 function
55 global homeostasis
56 great impact
57 homeostasis
58 hostile environmental factors
59 hub
60 impact
61 important part
62 inflammatory conditions
63 injury
64 internal environment
65 kynuric pathways
66 mechanism
67 melatonin
68 melatonin metabolism
69 melatonin synthesis
70 metabolism
71 metabolites
72 mitochondria
73 mitochondrial dysfunction
74 mitochondrial function
75 modulatory impact
76 note
77 noxious factors
78 origin
79 part
80 pathological processes
81 pathway
82 phylogenetic origin
83 physiological skin functions
84 process
85 protection
86 protective barrier
87 protective role
88 radiation
89 redox
90 repair
91 response
92 role
93 skin
94 skin cells
95 skin function
96 skin injury
97 skin response
98 stress
99 subsequent metabolism
100 substantial evidence
101 synthesis
102 ultraviolet radiation
103 schema:name Melatonin, mitochondria, and the skin
104 schema:pagination 3913-3925
105 schema:productId N2b5fa4356f4249e68ba7bac8c201f14e
106 Nae176d807c90458a818d196671874929
107 Nb0d2e3e8b15d41aeb4398adfcf3e407c
108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091200015
109 https://doi.org/10.1007/s00018-017-2617-7
110 schema:sdDatePublished 2022-09-02T16:02
111 schema:sdLicense https://scigraph.springernature.com/explorer/license/
112 schema:sdPublisher Na4f3a89ef343445b80c6c59e05b6a33a
113 schema:url https://doi.org/10.1007/s00018-017-2617-7
114 sgo:license sg:explorer/license/
115 sgo:sdDataset articles
116 rdf:type schema:ScholarlyArticle
117 N250240da6cd9453f9b3ac898d40c1975 schema:volumeNumber 74
118 rdf:type schema:PublicationVolume
119 N2b5fa4356f4249e68ba7bac8c201f14e schema:name dimensions_id
120 schema:value pub.1091200015
121 rdf:type schema:PropertyValue
122 N3122f062aa544697a19a4212efefb681 rdf:first sg:person.01103054167.16
123 rdf:rest N900dcce39d3345cfad2896d516bac126
124 N33ee6cbde0914f0ba8c5c4997b8eebad rdf:first sg:person.01357647717.25
125 rdf:rest Nf92ea83a80e943f69dc9590e9f8761b7
126 N4b6dcc69bbd34df7b30094e78845a50f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Skin
128 rdf:type schema:DefinedTerm
129 N4f0486b6b4df4f9ea23ab9251e01c084 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Antioxidants
131 rdf:type schema:DefinedTerm
132 N572fc59ccea040d4a0485e6e1cc3099e schema:issueNumber 21
133 rdf:type schema:PublicationIssue
134 N719d55d96a3343718190d9a44405edb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 N775218d9f1904225b953da70b2efad89 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Skin Physiological Phenomena
139 rdf:type schema:DefinedTerm
140 N886b590f387e4a4dbdb9613c16291738 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Mitochondria
142 rdf:type schema:DefinedTerm
143 N900dcce39d3345cfad2896d516bac126 rdf:first sg:person.01202776532.32
144 rdf:rest rdf:nil
145 Na4f3a89ef343445b80c6c59e05b6a33a schema:name Springer Nature - SN SciGraph project
146 rdf:type schema:Organization
147 Na620d49575d546fe8686cbfe080cc0d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Melatonin
149 rdf:type schema:DefinedTerm
150 Nae176d807c90458a818d196671874929 schema:name pubmed_id
151 schema:value 28803347
152 rdf:type schema:PropertyValue
153 Nb0d2e3e8b15d41aeb4398adfcf3e407c schema:name doi
154 schema:value 10.1007/s00018-017-2617-7
155 rdf:type schema:PropertyValue
156 Nc4a67c16031f4f30b58c08722bd0e939 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Animals
158 rdf:type schema:DefinedTerm
159 Nc79f88bb749c4d208a2f0fb3715458f9 rdf:first sg:person.016612034677.24
160 rdf:rest N33ee6cbde0914f0ba8c5c4997b8eebad
161 Nf0091061775c41f6ab488499c36ac3e1 rdf:first sg:person.0576400136.15
162 rdf:rest N3122f062aa544697a19a4212efefb681
163 Nf3007a5079794bb1bc4f625f3185d1b1 rdf:first sg:person.01122406003.26
164 rdf:rest Nf0091061775c41f6ab488499c36ac3e1
165 Nf92ea83a80e943f69dc9590e9f8761b7 rdf:first sg:person.01312653663.20
166 rdf:rest Nf3007a5079794bb1bc4f625f3185d1b1
167 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
168 schema:name Biological Sciences
169 rdf:type schema:DefinedTerm
170 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
171 schema:name Biochemistry and Cell Biology
172 rdf:type schema:DefinedTerm
173 sg:grant.2465059 http://pending.schema.org/fundedItem sg:pub.10.1007/s00018-017-2617-7
174 rdf:type schema:MonetaryGrant
175 sg:grant.2543249 http://pending.schema.org/fundedItem sg:pub.10.1007/s00018-017-2617-7
176 rdf:type schema:MonetaryGrant
177 sg:grant.7028403 http://pending.schema.org/fundedItem sg:pub.10.1007/s00018-017-2617-7
178 rdf:type schema:MonetaryGrant
179 sg:journal.1295005 schema:issn 1420-682X
180 1420-9071
181 schema:name Cellular and Molecular Life Sciences
182 schema:publisher Springer Nature
183 rdf:type schema:Periodical
184 sg:person.01103054167.16 schema:affiliation grid-institutes:grid.267301.1
185 schema:familyName Slominski
186 schema:givenName Radomir M.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103054167.16
188 rdf:type schema:Person
189 sg:person.01122406003.26 schema:affiliation grid-institutes:grid.265892.2
190 schema:familyName Kim
191 schema:givenName Tae-Kang
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122406003.26
193 rdf:type schema:Person
194 sg:person.01202776532.32 schema:affiliation grid-institutes:grid.265892.2
195 schema:familyName Zmijewski
196 schema:givenName Jaroslaw W.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202776532.32
198 rdf:type schema:Person
199 sg:person.01312653663.20 schema:affiliation grid-institutes:grid.17678.3f
200 schema:familyName Semak
201 schema:givenName Igor
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312653663.20
203 rdf:type schema:Person
204 sg:person.01357647717.25 schema:affiliation grid-institutes:grid.11451.30
205 schema:familyName Zmijewski
206 schema:givenName Michal A.
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357647717.25
208 rdf:type schema:Person
209 sg:person.016612034677.24 schema:affiliation grid-institutes:grid.280808.a
210 schema:familyName Slominski
211 schema:givenName Andrzej T.
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016612034677.24
213 rdf:type schema:Person
214 sg:person.0576400136.15 schema:affiliation grid-institutes:grid.265892.2
215 schema:familyName Janjetovic
216 schema:givenName Zorica
217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0576400136.15
218 rdf:type schema:Person
219 sg:pub.10.1007/978-3-642-19683-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029201023
220 https://doi.org/10.1007/978-3-642-19683-6
221 rdf:type schema:CreativeWork
222 sg:pub.10.1007/bf02505248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021419999
223 https://doi.org/10.1007/bf02505248
224 rdf:type schema:CreativeWork
225 sg:pub.10.1007/s00281-007-0060-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027640334
226 https://doi.org/10.1007/s00281-007-0060-9
227 rdf:type schema:CreativeWork
228 sg:pub.10.1007/s004030050258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005201623
229 https://doi.org/10.1007/s004030050258
230 rdf:type schema:CreativeWork
231 sg:pub.10.1007/s00774-009-0153-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017753540
232 https://doi.org/10.1007/s00774-009-0153-8
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/s10863-013-9534-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008462846
235 https://doi.org/10.1007/s10863-013-9534-8
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/1831821a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016124256
238 https://doi.org/10.1038/1831821a0
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/nchembio727 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043245379
241 https://doi.org/10.1038/nchembio727
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/s41598-017-01305-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085081257
244 https://doi.org/10.1038/s41598-017-01305-2
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/sj.onc.1206301 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008559287
247 https://doi.org/10.1038/sj.onc.1206301
248 rdf:type schema:CreativeWork
249 sg:pub.10.1186/1743-7075-2-22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007812417
250 https://doi.org/10.1186/1743-7075-2-22
251 rdf:type schema:CreativeWork
252 grid-institutes:grid.11451.30 schema:alternateName Department of Histology, Medical University of Gdańsk, Gdańsk, Poland
253 schema:name Department of Histology, Medical University of Gdańsk, Gdańsk, Poland
254 rdf:type schema:Organization
255 grid-institutes:grid.17678.3f schema:alternateName Department of Biochemistry, Belarusian State University, Minsk, Belarus
256 schema:name Department of Biochemistry, Belarusian State University, Minsk, Belarus
257 rdf:type schema:Organization
258 grid-institutes:grid.265892.2 schema:alternateName Department of Dermatology, Comprehensive Cancer Center Cancer Chemoprevention Program, University of Alabama at Birmingham, 35294, Birmingham, AL, USA
259 Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, USA
260 schema:name Department of Dermatology, Comprehensive Cancer Center Cancer Chemoprevention Program, University of Alabama at Birmingham, 35294, Birmingham, AL, USA
261 Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, USA
262 rdf:type schema:Organization
263 grid-institutes:grid.267301.1 schema:alternateName Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
264 schema:name Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
265 rdf:type schema:Organization
266 grid-institutes:grid.280808.a schema:alternateName VA Medical Center, Birmingham, AL, USA
267 schema:name Department of Dermatology, Comprehensive Cancer Center Cancer Chemoprevention Program, University of Alabama at Birmingham, 35294, Birmingham, AL, USA
268 VA Medical Center, Birmingham, AL, USA
269 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...