Adult neurogenesis in Parkinson’s disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02

AUTHORS

Franz Marxreiter, Martin Regensburger, Jürgen Winkler

ABSTRACT

Parkinson's disease (PD), the second most common neurodegenerative disorder, affects 1-2 % of humans aged 60 years and older. The diagnosis of PD is based on motor symptoms such as bradykinesia, rigidity, tremor, and postural instability associated with the striatal dopaminergic deficit that is linked to neurodegenerative processes in the substantia nigra (SN). In the past, cellular replacement strategies have been evaluated for their potential to alleviate these symptoms. Adult neurogenesis, the generation of new neurons within two proliferative niches in the adult brain, is being intensively studied as one potential mode for cell-based therapies. The subventricular zone provides new neurons for the olfactory bulb functionally contributing to olfaction. The subgranular zone of the hippocampus produces new granule neurons for the dentate gyrus, required for memory formation and proper processing of anxiety provoking stimuli. Recent years have revealed that PD is associated with non-motor symptoms such as hyposmia, anhedonia, lack of novelty seeking behavior, depression, and anxiety that are not directly associated with neurodegenerative processes in the SN. This broad spectrum of non-motor symptoms may partly rely on proper olfactorial processing and hippocampal function. Therefore, it is conceivable that some non-motor deficits in PD are related to defective adult neurogenesis. Accordingly, in animal models and postmortem studies of PD, adult neurogenesis is severely affected, although the exact mechanisms and effects of these changes are not yet fully understood or are under debate due to conflicting results. Here, we review the current concepts related to the dynamic interplay between endogenous cellular plasticity and PD-associated pathology. More... »

PAGES

459-473

References to SciGraph publications

  • 2002-02. Functional neurogenesis in the adult hippocampus in NATURE
  • 2008-05. Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease in NATURE MEDICINE
  • 2008-05. Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation in NATURE MEDICINE
  • 2006-07. Control of microglial neurotoxicity by the fractalkine receptor in NATURE NEUROSCIENCE
  • 2011-10. Corridors of migrating neurons in the human brain and their decline during infancy in NATURE
  • 2004-07. Dopamine depletion impairs precursor cell proliferation in Parkinson disease in NATURE NEUROSCIENCE
  • 2011-04. Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation in NATURE
  • 2011-09. α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation in NATURE
  • 2011-05. Parkinson’s disease risk score: moving to a premotor diagnosis in JOURNAL OF NEUROLOGY
  • 2006-11. Decreased Hippocampal Neurogenesis Following Olfactory Bulbectomy is Reversed by Repeated Citalopram Administration in CELLULAR AND MOLECULAR NEUROBIOLOGY
  • 2004-11. GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain in NATURE NEUROSCIENCE
  • 1998-11. Neurogenesis in the adult human hippocampus in NATURE MEDICINE
  • 1999-03. Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus in NATURE NEUROSCIENCE
  • 2006-08. Parkinson’s disease: a rethink of rodent models in EXPERIMENTAL BRAIN RESEARCH
  • 2001-12. Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice in BMC NEUROSCIENCE
  • 2009-10. Adult hippocampal neurogenesis is involved in anxiety-related behaviors in MOLECULAR PSYCHIATRY
  • 2004-10. Classic toxin-induced animal models of Parkinson’s disease: 6-OHDA and MPTP in CELL AND TISSUE RESEARCH
  • 2009. Neurogenesis in Substantia Nigra of Parkinsonian Brains? in BIRTH, LIFE AND DEATH OF DOPAMINERGIC NEURONS IN THE SUBSTANTIA NIGRA
  • 2006-04. Genetics of Parkinson disease: paradigm shifts and future prospects in NATURE REVIEWS GENETICS
  • 2007-03. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus in NATURE NEUROSCIENCE
  • 2009-10. Antidepressants increase neural progenitor cells in the human hippocampus in NEUROPSYCHOPHARMACOLOGY
  • 2009-06. Adult neurogenesis promotes synaptic plasticity in the olfactory bulb in NATURE NEUROSCIENCE
  • 1998-05. Adult treatment with haloperidol increases dentate granule cell proliferation in the gerbil hippocampus in JOURNAL OF NEURAL TRANSMISSION
  • 2002-09. Neuronal replacement from endogenous precursors in the adult brain after stroke in NATURE MEDICINE
  • 2011-07. Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders in ACTA NEUROPATHOLOGICA
  • 2002-05. Astroglia induce neurogenesis from adult neural stem cells in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00018-012-1062-x

    DOI

    http://dx.doi.org/10.1007/s00018-012-1062-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1037798309

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22766974


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Neurosciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease Models, Animal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hippocampus", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neurogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Olfactory Bulb", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Parkinson Disease", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "alpha-Synuclein", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum Erlangen", 
              "id": "https://www.grid.ac/institutes/grid.411668.c", 
              "name": [
                "Department of Molecular Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany", 
                "Department of Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marxreiter", 
            "givenName": "Franz", 
            "id": "sg:person.01336355422.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336355422.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum Erlangen", 
              "id": "https://www.grid.ac/institutes/grid.411668.c", 
              "name": [
                "Department of Molecular Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany", 
                "Department of Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Regensburger", 
            "givenName": "Martin", 
            "id": "sg:person.01222367762.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222367762.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e4tsklinikum Erlangen", 
              "id": "https://www.grid.ac/institutes/grid.411668.c", 
              "name": [
                "Department of Molecular Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany", 
                "Department of Neurosciences, University of California, San Diego 9500 Gilman Drive, 92093-0662, La Jolla, CA, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Winkler", 
            "givenName": "J\u00fcrgen", 
            "id": "sg:person.010760613337.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010760613337.32"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00441-004-0938-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000240995", 
              "https://doi.org/10.1007/s00441-004-0938-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-004-0938-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000240995", 
              "https://doi.org/10.1007/s00441-004-0938-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00441-004-0938-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000240995", 
              "https://doi.org/10.1007/s00441-004-0938-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.20506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000546205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.20506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000546205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2005.08.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000552145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2005.08.018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000552145"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.cellbio.042308.113256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000621893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000870397", 
              "https://doi.org/10.1038/nn.2298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn.2298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000870397", 
              "https://doi.org/10.1038/nn.2298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2009.11.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001181542"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jnr.10231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001607426"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/neuro.22.003.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001827965"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0903691106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001886419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1531-8257(200007)15:4<669::aid-mds1011>3.0.co;2-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001957187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/mp.2009.15", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002292489", 
              "https://doi.org/10.1038/mp.2009.15"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002915711", 
              "https://doi.org/10.1038/nm747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002915711", 
              "https://doi.org/10.1038/nm747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4859-05.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003220887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1460-9568.2002.02062.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003467834"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2004.11.056", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003512232"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jns.2006.05.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003549802"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.conb.2010.04.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003561107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1005005107", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003691723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cub.2007.01.074", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003693826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2011.06.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003945438"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1120-05.2005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004445309"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neurobiolaging.2006.12.016", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004483763"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2011.07933.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005690450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2003.10.040", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006121140"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2011.05.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006700754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0710156104", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009659022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2005.03073.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009728373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/417039a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009958221", 
              "https://doi.org/10.1038/417039a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/417039a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009958221", 
              "https://doi.org/10.1038/417039a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0803955106", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010056299"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2009.01.038", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010067908"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(93)90175-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010387852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(93)90175-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010387852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0066-08.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010728508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1747", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010937919", 
              "https://doi.org/10.1038/nm1747"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00415-011-5952-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011035372", 
              "https://doi.org/10.1007/s00415-011-5952-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0278-5846(96)00157-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011715531"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2004.03486.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012110749"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1460-9568.2002.02238.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012792359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2009.07.013", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012860136"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0363-11.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013074362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2007.10.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013196733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s007020050061", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014413954", 
              "https://doi.org/10.1007/s007020050061"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2010.04.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014420876"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0896-6273(00)80886-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014547650"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2005.07.054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014649204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2005.07.054", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014649204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2633-06.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015647415"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1131955100", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015687983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0837-06.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015950085"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2005-0281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016519185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/stemcells.2005-0281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016519185"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(02)00065-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016528708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0197-4580(02)00065-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016528708"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1100976108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016661335"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.10874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017126143"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0896-6273(93)90281-u", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017263097"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/archneurpsyc.1939.02270140063005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017886033"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0166-4328(01)00309-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018056372"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2009.75", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018092768", 
              "https://doi.org/10.1038/npp.2009.75"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/npp.2009.75", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018092768", 
              "https://doi.org/10.1038/npp.2009.75"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000017427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018245728"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2007.09.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019220375"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/4151030a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019590606", 
              "https://doi.org/10.1038/4151030a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/4151030a", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019590606", 
              "https://doi.org/10.1038/4151030a"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2008.06.052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019810758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2004.02823.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021301013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021332650", 
              "https://doi.org/10.1038/nn1715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1715", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021332650", 
              "https://doi.org/10.1038/nn1715"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(02)00862-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022579954"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1847", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022908383", 
              "https://doi.org/10.1038/nn1847"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10487", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023794118", 
              "https://doi.org/10.1038/nature10487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1083328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023861505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2007.11.036", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023885141"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1037/0735-7044.118.5.1033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024016656"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2004.02378.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024440300"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.09.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024515362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2005.09.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024515362"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.brainres.2006.05.111", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024606817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuro.2004.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024756937"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0092-8674(00)80783-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024856119"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.903030202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024990789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2011.09.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026017635"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.10713", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026833132"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/(sici)1096-9861(19990802)410:3<503::aid-cne11>3.0.co;2-h", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027040972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0306-4522(98)00693-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027482892"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0014-2999(00)00904-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027618359"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s1474-4422(09)70062-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027860940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.111.627802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028283670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1161/strokeaha.111.627802", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028283670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10571-006-9090-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028389336", 
              "https://doi.org/10.1007/s10571-006-9090-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10571-006-9090-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028389336", 
              "https://doi.org/10.1007/s10571-006-9090-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0306-4522(03)00036-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028605101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0306-4522(03)00036-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028605101"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1197-11.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028658897"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.4913-10.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028795454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnen/63.11.1155", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029003422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm1746", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029954184", 
              "https://doi.org/10.1038/nm1746"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0896-6273(93)90228-j", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030721056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbr.2005.02.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030996666"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2005.11.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031510871"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature09817", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031775558", 
              "https://doi.org/10.1038/nature09817"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.21751", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032028149"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2010.06727.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032411594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2010.06727.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032411594"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/nen.0b013e3181630cff", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032847388"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.pneurobio.2005.01.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034071204"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.06-6183com", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034098367"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.172514599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034504325"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cne.901370404", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034617255"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnbeh.2010.00176", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035581831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035614683", 
              "https://doi.org/10.1038/3305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/3305", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035614683", 
              "https://doi.org/10.1038/3305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200508010-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036320293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200508010-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036320293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001756-200508010-00003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036320293"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1340", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036332544", 
              "https://doi.org/10.1038/nn1340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1340", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036332544", 
              "https://doi.org/10.1038/nn1340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0237-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036399703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2202-2-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036750167", 
              "https://doi.org/10.1186/1471-2202-2-11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0007017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036787337"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.stem.2010.03.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037118397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tins.2010.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037144630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnen/60.8.741", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037432905"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1173215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038374449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1173215", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038374449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(94)90397-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038430002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0306-4522(94)90397-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038430002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2617-07.2007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038587662"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.97.2.571", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038902993"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2011.06.043", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039025427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pbio.1000373", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039238056"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-3-211-92660-4_23", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039751550", 
              "https://doi.org/10.1007/978-3-211-92660-4_23"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.96.23.13427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039908074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0009260", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039984154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/mcne.1995.1035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040199852"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/6368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041138335", 
              "https://doi.org/10.1038/6368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/6368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041138335", 
              "https://doi.org/10.1038/6368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.3040-07.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042052449"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2005.08.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042625172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2005.08.028", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042625172"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042739174", 
              "https://doi.org/10.1038/nn1265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042739174", 
              "https://doi.org/10.1038/nn1265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nn1265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042739174", 
              "https://doi.org/10.1038/nn1265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.biopsych.2008.02.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042756703"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2954-08.2008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042940144"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbrc.2006.01.057", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043287561"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0406283101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043381340"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.22009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043398630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90662-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043517258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2010.05.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043918363"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10324", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043919445", 
              "https://doi.org/10.1038/nature10324"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.25087", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045166108"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2003.08.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045251861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gde.2003.08.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045251861"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00401-011-0830-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045348226", 
              "https://doi.org/10.1007/s00401-011-0830-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2009.06641.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045439552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m109.081125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046013237"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.2406-09.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046356947"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ana.10393", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046677147"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.expneurol.2010.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046953298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.21813", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047171989"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.0618-11.2011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047391712"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0401229101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047498883"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1038/mt.2010.115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047778765"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/mds.23795", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048316767"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2009.06324.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048340670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1471-4159.2009.06324.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048340670"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048971516", 
              "https://doi.org/10.1038/nrg1831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg1831", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048971516", 
              "https://doi.org/10.1038/nrg1831"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/brain/awr256", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049189230"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuron.2007.05.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049778354"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1096/fj.09-151456", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049819700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1460-9568.2011.07604.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050090562"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1055-8330(95)90015-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050992605"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.287.5456.1265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051109253"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2005.01.004", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051173079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00221-006-0461-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051483979", 
              "https://doi.org/10.1007/s00221-006-0461-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00221-006-0461-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051483979", 
              "https://doi.org/10.1007/s00221-006-0461-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0306-4522(96)00545-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051529664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/jn.00076.2009", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052172882"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2008.01.033", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052266867"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2010.07.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052483631"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.nbd.2010.12.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053262517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1089/scd.2006.15.407", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059309593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1136281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062455025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.271.5251.978", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062552258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.274.5293.1678", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062555128"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.6823561", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062640856"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.8178174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062653055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e318198dace", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e318198dace", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e318198dace", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064354261"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181f39d0e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064355585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181f39d0e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064355585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1212/wnl.0b013e3181f39d0e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064355585"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1667/rr3206", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1068196281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.20-24-09104.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074740264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.22-03-00629.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1074991982"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.22-15-06639.2002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075096819"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.15-06-04687.1995", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082509055"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.16-06-02027.1996", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1082877022"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.17-10-03727.1997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083083006"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.17-13-05046.1997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083103223"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.17-15-05820.1997", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083117119"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-02", 
        "datePublishedReg": "2013-02-01", 
        "description": "Parkinson's disease (PD), the second most common neurodegenerative disorder, affects 1-2 % of humans aged 60 years and older. The diagnosis of PD is based on motor symptoms such as bradykinesia, rigidity, tremor, and postural instability associated with the striatal dopaminergic deficit that is linked to neurodegenerative processes in the substantia nigra (SN). In the past, cellular replacement strategies have been evaluated for their potential to alleviate these symptoms. Adult neurogenesis, the generation of new neurons within two proliferative niches in the adult brain, is being intensively studied as one potential mode for cell-based therapies. The subventricular zone provides new neurons for the olfactory bulb functionally contributing to olfaction. The subgranular zone of the hippocampus produces new granule neurons for the dentate gyrus, required for memory formation and proper processing of anxiety provoking stimuli. Recent years have revealed that PD is associated with non-motor symptoms such as hyposmia, anhedonia, lack of novelty seeking behavior, depression, and anxiety that are not directly associated with neurodegenerative processes in the SN. This broad spectrum of non-motor symptoms may partly rely on proper olfactorial processing and hippocampal function. Therefore, it is conceivable that some non-motor deficits in PD are related to defective adult neurogenesis. Accordingly, in animal models and postmortem studies of PD, adult neurogenesis is severely affected, although the exact mechanisms and effects of these changes are not yet fully understood or are under debate due to conflicting results. Here, we review the current concepts related to the dynamic interplay between endogenous cellular plasticity and PD-associated pathology.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00018-012-1062-x", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1295005", 
            "issn": [
              "1420-682X", 
              "1420-9071"
            ], 
            "name": "Cellular and Molecular Life Sciences", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "70"
          }
        ], 
        "name": "Adult neurogenesis in Parkinson\u2019s disease", 
        "pagination": "459-473", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "b40f7ee50fbf13f0f393e06e15f6ffb6e9a6e6f03745488f9938533541fc9e4a"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "22766974"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9705402"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00018-012-1062-x"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1037798309"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00018-012-1062-x", 
          "https://app.dimensions.ai/details/publication/pub.1037798309"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:48", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000496.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007/s00018-012-1062-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00018-012-1062-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00018-012-1062-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00018-012-1062-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00018-012-1062-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    669 TRIPLES      21 PREDICATES      212 URIs      30 LITERALS      18 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00018-012-1062-x schema:about N2f6d2199557743169148e5286687421c
    2 N368b2c2275604063852c1ab981dde971
    3 N39dd506391284bab84848380463fc719
    4 N4a4f8a0595e0466288a31a945b4c6847
    5 N59fc5f99d6b04a218ce674c17a062065
    6 N6633ae870d3c4520962637fd5b99795c
    7 Ndee2a786d3c8437a950bb60a61e43ead
    8 Ne8fb27c7177343cd9bdbcbe82c38c50e
    9 Nf1c7f07f55ea4970a2999b19c3eefec2
    10 anzsrc-for:11
    11 anzsrc-for:1109
    12 schema:author N0d211cb51dc34d5b86ba502ad2fab752
    13 schema:citation sg:pub.10.1007/978-3-211-92660-4_23
    14 sg:pub.10.1007/s00221-006-0461-3
    15 sg:pub.10.1007/s00401-011-0830-2
    16 sg:pub.10.1007/s00415-011-5952-x
    17 sg:pub.10.1007/s00441-004-0938-y
    18 sg:pub.10.1007/s007020050061
    19 sg:pub.10.1007/s10571-006-9090-4
    20 sg:pub.10.1038/3305
    21 sg:pub.10.1038/4151030a
    22 sg:pub.10.1038/417039a
    23 sg:pub.10.1038/6368
    24 sg:pub.10.1038/mp.2009.15
    25 sg:pub.10.1038/nature09817
    26 sg:pub.10.1038/nature10324
    27 sg:pub.10.1038/nature10487
    28 sg:pub.10.1038/nm1746
    29 sg:pub.10.1038/nm1747
    30 sg:pub.10.1038/nm747
    31 sg:pub.10.1038/nn.2298
    32 sg:pub.10.1038/nn1265
    33 sg:pub.10.1038/nn1340
    34 sg:pub.10.1038/nn1715
    35 sg:pub.10.1038/nn1847
    36 sg:pub.10.1038/npp.2009.75
    37 sg:pub.10.1038/nrg1831
    38 sg:pub.10.1186/1471-2202-2-11
    39 https://doi.org/10.1001/archneurpsyc.1939.02270140063005
    40 https://doi.org/10.1002/(sici)1096-9861(19990802)410:3<503::aid-cne11>3.0.co;2-h
    41 https://doi.org/10.1002/1531-8257(200007)15:4<669::aid-mds1011>3.0.co;2-5
    42 https://doi.org/10.1002/ana.10393
    43 https://doi.org/10.1002/ana.20506
    44 https://doi.org/10.1002/cne.10874
    45 https://doi.org/10.1002/cne.901370404
    46 https://doi.org/10.1002/cne.903030202
    47 https://doi.org/10.1002/jnr.10231
    48 https://doi.org/10.1002/mds.10713
    49 https://doi.org/10.1002/mds.21751
    50 https://doi.org/10.1002/mds.21813
    51 https://doi.org/10.1002/mds.22009
    52 https://doi.org/10.1002/mds.23795
    53 https://doi.org/10.1002/mds.25087
    54 https://doi.org/10.1006/mcne.1995.1035
    55 https://doi.org/10.1016/0092-8674(90)90662-x
    56 https://doi.org/10.1016/0306-4522(93)90175-f
    57 https://doi.org/10.1016/0306-4522(94)90397-2
    58 https://doi.org/10.1016/0896-6273(93)90228-j
    59 https://doi.org/10.1016/0896-6273(93)90281-u
    60 https://doi.org/10.1016/1055-8330(95)90015-2
    61 https://doi.org/10.1016/j.bbr.2005.02.023
    62 https://doi.org/10.1016/j.bbrc.2006.01.057
    63 https://doi.org/10.1016/j.biopsych.2008.02.022
    64 https://doi.org/10.1016/j.brainres.2006.05.111
    65 https://doi.org/10.1016/j.cell.2005.09.028
    66 https://doi.org/10.1016/j.cell.2008.01.033
    67 https://doi.org/10.1016/j.cell.2009.01.038
    68 https://doi.org/10.1016/j.conb.2010.04.010
    69 https://doi.org/10.1016/j.cub.2007.01.074
    70 https://doi.org/10.1016/j.expneurol.2005.08.028
    71 https://doi.org/10.1016/j.expneurol.2005.11.004
    72 https://doi.org/10.1016/j.expneurol.2007.10.012
    73 https://doi.org/10.1016/j.expneurol.2009.07.013
    74 https://doi.org/10.1016/j.expneurol.2010.01.004
    75 https://doi.org/10.1016/j.gde.2003.08.012
    76 https://doi.org/10.1016/j.jns.2006.05.011
    77 https://doi.org/10.1016/j.nbd.2005.01.004
    78 https://doi.org/10.1016/j.nbd.2005.08.018
    79 https://doi.org/10.1016/j.nbd.2010.07.010
    80 https://doi.org/10.1016/j.nbd.2010.12.008
    81 https://doi.org/10.1016/j.nbd.2011.06.017
    82 https://doi.org/10.1016/j.neuro.2004.05.002
    83 https://doi.org/10.1016/j.neurobiolaging.2006.12.016
    84 https://doi.org/10.1016/j.neurobiolaging.2009.11.022
    85 https://doi.org/10.1016/j.neuron.2007.05.002
    86 https://doi.org/10.1016/j.neuron.2010.04.034
    87 https://doi.org/10.1016/j.neuron.2011.05.022
    88 https://doi.org/10.1016/j.neuroscience.2003.10.040
    89 https://doi.org/10.1016/j.neuroscience.2004.11.056
    90 https://doi.org/10.1016/j.neuroscience.2005.07.054
    91 https://doi.org/10.1016/j.neuroscience.2007.11.036
    92 https://doi.org/10.1016/j.neuroscience.2008.06.052
    93 https://doi.org/10.1016/j.neuroscience.2010.05.012
    94 https://doi.org/10.1016/j.neuroscience.2011.06.043
    95 https://doi.org/10.1016/j.pneurobio.2005.01.001
    96 https://doi.org/10.1016/j.stem.2007.09.002
    97 https://doi.org/10.1016/j.stem.2010.03.017
    98 https://doi.org/10.1016/j.stem.2011.09.011
    99 https://doi.org/10.1016/j.tins.2010.09.006
    100 https://doi.org/10.1016/s0014-2999(00)00904-3
    101 https://doi.org/10.1016/s0092-8674(00)80783-7
    102 https://doi.org/10.1016/s0092-8674(02)00862-0
    103 https://doi.org/10.1016/s0166-4328(01)00309-6
    104 https://doi.org/10.1016/s0197-4580(02)00065-9
    105 https://doi.org/10.1016/s0278-5846(96)00157-1
    106 https://doi.org/10.1016/s0306-4522(03)00036-8
    107 https://doi.org/10.1016/s0306-4522(96)00545-3
    108 https://doi.org/10.1016/s0306-4522(98)00693-9
    109 https://doi.org/10.1016/s0896-6273(00)80886-7
    110 https://doi.org/10.1016/s1474-4422(09)70062-6
    111 https://doi.org/10.1037/0735-7044.118.5.1033
    112 https://doi.org/10.1038/mt.2010.115
    113 https://doi.org/10.1046/j.1460-9568.2002.02062.x
    114 https://doi.org/10.1046/j.1460-9568.2002.02238.x
    115 https://doi.org/10.1073/pnas.0401229101
    116 https://doi.org/10.1073/pnas.0406283101
    117 https://doi.org/10.1073/pnas.0710156104
    118 https://doi.org/10.1073/pnas.0803955106
    119 https://doi.org/10.1073/pnas.0903691106
    120 https://doi.org/10.1073/pnas.1005005107
    121 https://doi.org/10.1073/pnas.1100976108
    122 https://doi.org/10.1073/pnas.1131955100
    123 https://doi.org/10.1073/pnas.172514599
    124 https://doi.org/10.1073/pnas.96.23.13427
    125 https://doi.org/10.1073/pnas.97.2.571
    126 https://doi.org/10.1074/jbc.m109.081125
    127 https://doi.org/10.1089/scd.2006.15.407
    128 https://doi.org/10.1093/brain/awr256
    129 https://doi.org/10.1093/jnen/60.8.741
    130 https://doi.org/10.1093/jnen/63.11.1155
    131 https://doi.org/10.1096/fj.06-6183com
    132 https://doi.org/10.1096/fj.09-151456
    133 https://doi.org/10.1097/00001756-200508010-00003
    134 https://doi.org/10.1097/nen.0b013e3181630cff
    135 https://doi.org/10.1111/j.1460-9568.2004.03486.x
    136 https://doi.org/10.1111/j.1460-9568.2009.06641.x
    137 https://doi.org/10.1111/j.1460-9568.2011.07604.x
    138 https://doi.org/10.1111/j.1460-9568.2011.07933.x
    139 https://doi.org/10.1111/j.1471-4159.2004.02378.x
    140 https://doi.org/10.1111/j.1471-4159.2004.02823.x
    141 https://doi.org/10.1111/j.1471-4159.2005.03073.x
    142 https://doi.org/10.1111/j.1471-4159.2009.06324.x
    143 https://doi.org/10.1111/j.1471-4159.2010.06727.x
    144 https://doi.org/10.1126/science.1083328
    145 https://doi.org/10.1126/science.1136281
    146 https://doi.org/10.1126/science.1173215
    147 https://doi.org/10.1126/science.271.5251.978
    148 https://doi.org/10.1126/science.274.5293.1678
    149 https://doi.org/10.1126/science.287.5456.1265
    150 https://doi.org/10.1126/science.6823561
    151 https://doi.org/10.1126/science.8178174
    152 https://doi.org/10.1146/annurev.cellbio.042308.113256
    153 https://doi.org/10.1152/jn.00076.2009
    154 https://doi.org/10.1159/000017427
    155 https://doi.org/10.1161/strokeaha.111.627802
    156 https://doi.org/10.1212/wnl.0b013e318198dace
    157 https://doi.org/10.1212/wnl.0b013e3181f39d0e
    158 https://doi.org/10.1371/journal.pbio.1000373
    159 https://doi.org/10.1371/journal.pone.0007017
    160 https://doi.org/10.1371/journal.pone.0009260
    161 https://doi.org/10.1523/jneurosci.0066-08.2008
    162 https://doi.org/10.1523/jneurosci.0237-07.2007
    163 https://doi.org/10.1523/jneurosci.0363-11.2011
    164 https://doi.org/10.1523/jneurosci.0618-11.2011
    165 https://doi.org/10.1523/jneurosci.0837-06.2006
    166 https://doi.org/10.1523/jneurosci.1120-05.2005
    167 https://doi.org/10.1523/jneurosci.1197-11.2011
    168 https://doi.org/10.1523/jneurosci.15-06-04687.1995
    169 https://doi.org/10.1523/jneurosci.16-06-02027.1996
    170 https://doi.org/10.1523/jneurosci.17-10-03727.1997
    171 https://doi.org/10.1523/jneurosci.17-13-05046.1997
    172 https://doi.org/10.1523/jneurosci.17-15-05820.1997
    173 https://doi.org/10.1523/jneurosci.20-24-09104.2000
    174 https://doi.org/10.1523/jneurosci.22-03-00629.2002
    175 https://doi.org/10.1523/jneurosci.22-15-06639.2002
    176 https://doi.org/10.1523/jneurosci.2406-09.2009
    177 https://doi.org/10.1523/jneurosci.2617-07.2007
    178 https://doi.org/10.1523/jneurosci.2633-06.2006
    179 https://doi.org/10.1523/jneurosci.2954-08.2008
    180 https://doi.org/10.1523/jneurosci.3040-07.2008
    181 https://doi.org/10.1523/jneurosci.4859-05.2006
    182 https://doi.org/10.1523/jneurosci.4913-10.2011
    183 https://doi.org/10.1634/stemcells.2005-0281
    184 https://doi.org/10.1667/rr3206
    185 https://doi.org/10.3389/fnbeh.2010.00176
    186 https://doi.org/10.3389/neuro.22.003.2009
    187 schema:datePublished 2013-02
    188 schema:datePublishedReg 2013-02-01
    189 schema:description Parkinson's disease (PD), the second most common neurodegenerative disorder, affects 1-2 % of humans aged 60 years and older. The diagnosis of PD is based on motor symptoms such as bradykinesia, rigidity, tremor, and postural instability associated with the striatal dopaminergic deficit that is linked to neurodegenerative processes in the substantia nigra (SN). In the past, cellular replacement strategies have been evaluated for their potential to alleviate these symptoms. Adult neurogenesis, the generation of new neurons within two proliferative niches in the adult brain, is being intensively studied as one potential mode for cell-based therapies. The subventricular zone provides new neurons for the olfactory bulb functionally contributing to olfaction. The subgranular zone of the hippocampus produces new granule neurons for the dentate gyrus, required for memory formation and proper processing of anxiety provoking stimuli. Recent years have revealed that PD is associated with non-motor symptoms such as hyposmia, anhedonia, lack of novelty seeking behavior, depression, and anxiety that are not directly associated with neurodegenerative processes in the SN. This broad spectrum of non-motor symptoms may partly rely on proper olfactorial processing and hippocampal function. Therefore, it is conceivable that some non-motor deficits in PD are related to defective adult neurogenesis. Accordingly, in animal models and postmortem studies of PD, adult neurogenesis is severely affected, although the exact mechanisms and effects of these changes are not yet fully understood or are under debate due to conflicting results. Here, we review the current concepts related to the dynamic interplay between endogenous cellular plasticity and PD-associated pathology.
    190 schema:genre research_article
    191 schema:inLanguage en
    192 schema:isAccessibleForFree false
    193 schema:isPartOf N4a77c934bc9c41f482eefe6a61fee839
    194 Ncfd25c09741a41d4b0fc65110ac31546
    195 sg:journal.1295005
    196 schema:name Adult neurogenesis in Parkinson’s disease
    197 schema:pagination 459-473
    198 schema:productId N0ad02dc455344742ab94aaf657699374
    199 N88a6b84aa2f04615b53bee85da58a961
    200 N91ae297bb39b4f1db86729f46edfc28c
    201 Nb5ea4a5a42c6489bb14a8d1cbf68013f
    202 Nfaf133c3314d40b8b06caa42e5b69809
    203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037798309
    204 https://doi.org/10.1007/s00018-012-1062-x
    205 schema:sdDatePublished 2019-04-10T15:48
    206 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    207 schema:sdPublisher N351153b62abe4d15bebe36fa204b80ad
    208 schema:url http://link.springer.com/10.1007/s00018-012-1062-x
    209 sgo:license sg:explorer/license/
    210 sgo:sdDataset articles
    211 rdf:type schema:ScholarlyArticle
    212 N0ad02dc455344742ab94aaf657699374 schema:name pubmed_id
    213 schema:value 22766974
    214 rdf:type schema:PropertyValue
    215 N0d211cb51dc34d5b86ba502ad2fab752 rdf:first sg:person.01336355422.14
    216 rdf:rest N84639b6cd1834be49e743681039528cd
    217 N2f6d2199557743169148e5286687421c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    218 schema:name Disease Models, Animal
    219 rdf:type schema:DefinedTerm
    220 N351153b62abe4d15bebe36fa204b80ad schema:name Springer Nature - SN SciGraph project
    221 rdf:type schema:Organization
    222 N368b2c2275604063852c1ab981dde971 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    223 schema:name Neurogenesis
    224 rdf:type schema:DefinedTerm
    225 N39dd506391284bab84848380463fc719 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    226 schema:name 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    227 rdf:type schema:DefinedTerm
    228 N4a4f8a0595e0466288a31a945b4c6847 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    229 schema:name Humans
    230 rdf:type schema:DefinedTerm
    231 N4a77c934bc9c41f482eefe6a61fee839 schema:volumeNumber 70
    232 rdf:type schema:PublicationVolume
    233 N59fc5f99d6b04a218ce674c17a062065 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    234 schema:name Parkinson Disease
    235 rdf:type schema:DefinedTerm
    236 N6633ae870d3c4520962637fd5b99795c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    237 schema:name Hippocampus
    238 rdf:type schema:DefinedTerm
    239 N84639b6cd1834be49e743681039528cd rdf:first sg:person.01222367762.89
    240 rdf:rest Naafc9d03d3c3450692fb5757801ff049
    241 N88a6b84aa2f04615b53bee85da58a961 schema:name readcube_id
    242 schema:value b40f7ee50fbf13f0f393e06e15f6ffb6e9a6e6f03745488f9938533541fc9e4a
    243 rdf:type schema:PropertyValue
    244 N91ae297bb39b4f1db86729f46edfc28c schema:name dimensions_id
    245 schema:value pub.1037798309
    246 rdf:type schema:PropertyValue
    247 Naafc9d03d3c3450692fb5757801ff049 rdf:first sg:person.010760613337.32
    248 rdf:rest rdf:nil
    249 Nb5ea4a5a42c6489bb14a8d1cbf68013f schema:name doi
    250 schema:value 10.1007/s00018-012-1062-x
    251 rdf:type schema:PropertyValue
    252 Ncfd25c09741a41d4b0fc65110ac31546 schema:issueNumber 3
    253 rdf:type schema:PublicationIssue
    254 Ndee2a786d3c8437a950bb60a61e43ead schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    255 schema:name Animals
    256 rdf:type schema:DefinedTerm
    257 Ne8fb27c7177343cd9bdbcbe82c38c50e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    258 schema:name alpha-Synuclein
    259 rdf:type schema:DefinedTerm
    260 Nf1c7f07f55ea4970a2999b19c3eefec2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    261 schema:name Olfactory Bulb
    262 rdf:type schema:DefinedTerm
    263 Nfaf133c3314d40b8b06caa42e5b69809 schema:name nlm_unique_id
    264 schema:value 9705402
    265 rdf:type schema:PropertyValue
    266 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    267 schema:name Medical and Health Sciences
    268 rdf:type schema:DefinedTerm
    269 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
    270 schema:name Neurosciences
    271 rdf:type schema:DefinedTerm
    272 sg:journal.1295005 schema:issn 1420-682X
    273 1420-9071
    274 schema:name Cellular and Molecular Life Sciences
    275 rdf:type schema:Periodical
    276 sg:person.010760613337.32 schema:affiliation https://www.grid.ac/institutes/grid.411668.c
    277 schema:familyName Winkler
    278 schema:givenName Jürgen
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010760613337.32
    280 rdf:type schema:Person
    281 sg:person.01222367762.89 schema:affiliation https://www.grid.ac/institutes/grid.411668.c
    282 schema:familyName Regensburger
    283 schema:givenName Martin
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222367762.89
    285 rdf:type schema:Person
    286 sg:person.01336355422.14 schema:affiliation https://www.grid.ac/institutes/grid.411668.c
    287 schema:familyName Marxreiter
    288 schema:givenName Franz
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01336355422.14
    290 rdf:type schema:Person
    291 sg:pub.10.1007/978-3-211-92660-4_23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039751550
    292 https://doi.org/10.1007/978-3-211-92660-4_23
    293 rdf:type schema:CreativeWork
    294 sg:pub.10.1007/s00221-006-0461-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051483979
    295 https://doi.org/10.1007/s00221-006-0461-3
    296 rdf:type schema:CreativeWork
    297 sg:pub.10.1007/s00401-011-0830-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045348226
    298 https://doi.org/10.1007/s00401-011-0830-2
    299 rdf:type schema:CreativeWork
    300 sg:pub.10.1007/s00415-011-5952-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011035372
    301 https://doi.org/10.1007/s00415-011-5952-x
    302 rdf:type schema:CreativeWork
    303 sg:pub.10.1007/s00441-004-0938-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1000240995
    304 https://doi.org/10.1007/s00441-004-0938-y
    305 rdf:type schema:CreativeWork
    306 sg:pub.10.1007/s007020050061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014413954
    307 https://doi.org/10.1007/s007020050061
    308 rdf:type schema:CreativeWork
    309 sg:pub.10.1007/s10571-006-9090-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028389336
    310 https://doi.org/10.1007/s10571-006-9090-4
    311 rdf:type schema:CreativeWork
    312 sg:pub.10.1038/3305 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035614683
    313 https://doi.org/10.1038/3305
    314 rdf:type schema:CreativeWork
    315 sg:pub.10.1038/4151030a schema:sameAs https://app.dimensions.ai/details/publication/pub.1019590606
    316 https://doi.org/10.1038/4151030a
    317 rdf:type schema:CreativeWork
    318 sg:pub.10.1038/417039a schema:sameAs https://app.dimensions.ai/details/publication/pub.1009958221
    319 https://doi.org/10.1038/417039a
    320 rdf:type schema:CreativeWork
    321 sg:pub.10.1038/6368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041138335
    322 https://doi.org/10.1038/6368
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1038/mp.2009.15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002292489
    325 https://doi.org/10.1038/mp.2009.15
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1038/nature09817 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031775558
    328 https://doi.org/10.1038/nature09817
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1038/nature10324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043919445
    331 https://doi.org/10.1038/nature10324
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1038/nature10487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023794118
    334 https://doi.org/10.1038/nature10487
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1038/nm1746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029954184
    337 https://doi.org/10.1038/nm1746
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1038/nm1747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010937919
    340 https://doi.org/10.1038/nm1747
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/nm747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002915711
    343 https://doi.org/10.1038/nm747
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/nn.2298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000870397
    346 https://doi.org/10.1038/nn.2298
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/nn1265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042739174
    349 https://doi.org/10.1038/nn1265
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/nn1340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036332544
    352 https://doi.org/10.1038/nn1340
    353 rdf:type schema:CreativeWork
    354 sg:pub.10.1038/nn1715 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021332650
    355 https://doi.org/10.1038/nn1715
    356 rdf:type schema:CreativeWork
    357 sg:pub.10.1038/nn1847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022908383
    358 https://doi.org/10.1038/nn1847
    359 rdf:type schema:CreativeWork
    360 sg:pub.10.1038/npp.2009.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018092768
    361 https://doi.org/10.1038/npp.2009.75
    362 rdf:type schema:CreativeWork
    363 sg:pub.10.1038/nrg1831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048971516
    364 https://doi.org/10.1038/nrg1831
    365 rdf:type schema:CreativeWork
    366 sg:pub.10.1186/1471-2202-2-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036750167
    367 https://doi.org/10.1186/1471-2202-2-11
    368 rdf:type schema:CreativeWork
    369 https://doi.org/10.1001/archneurpsyc.1939.02270140063005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017886033
    370 rdf:type schema:CreativeWork
    371 https://doi.org/10.1002/(sici)1096-9861(19990802)410:3<503::aid-cne11>3.0.co;2-h schema:sameAs https://app.dimensions.ai/details/publication/pub.1027040972
    372 rdf:type schema:CreativeWork
    373 https://doi.org/10.1002/1531-8257(200007)15:4<669::aid-mds1011>3.0.co;2-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001957187
    374 rdf:type schema:CreativeWork
    375 https://doi.org/10.1002/ana.10393 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046677147
    376 rdf:type schema:CreativeWork
    377 https://doi.org/10.1002/ana.20506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000546205
    378 rdf:type schema:CreativeWork
    379 https://doi.org/10.1002/cne.10874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017126143
    380 rdf:type schema:CreativeWork
    381 https://doi.org/10.1002/cne.901370404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034617255
    382 rdf:type schema:CreativeWork
    383 https://doi.org/10.1002/cne.903030202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024990789
    384 rdf:type schema:CreativeWork
    385 https://doi.org/10.1002/jnr.10231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001607426
    386 rdf:type schema:CreativeWork
    387 https://doi.org/10.1002/mds.10713 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026833132
    388 rdf:type schema:CreativeWork
    389 https://doi.org/10.1002/mds.21751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032028149
    390 rdf:type schema:CreativeWork
    391 https://doi.org/10.1002/mds.21813 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047171989
    392 rdf:type schema:CreativeWork
    393 https://doi.org/10.1002/mds.22009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043398630
    394 rdf:type schema:CreativeWork
    395 https://doi.org/10.1002/mds.23795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048316767
    396 rdf:type schema:CreativeWork
    397 https://doi.org/10.1002/mds.25087 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045166108
    398 rdf:type schema:CreativeWork
    399 https://doi.org/10.1006/mcne.1995.1035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040199852
    400 rdf:type schema:CreativeWork
    401 https://doi.org/10.1016/0092-8674(90)90662-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043517258
    402 rdf:type schema:CreativeWork
    403 https://doi.org/10.1016/0306-4522(93)90175-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1010387852
    404 rdf:type schema:CreativeWork
    405 https://doi.org/10.1016/0306-4522(94)90397-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038430002
    406 rdf:type schema:CreativeWork
    407 https://doi.org/10.1016/0896-6273(93)90228-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1030721056
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1016/0896-6273(93)90281-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1017263097
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1016/1055-8330(95)90015-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050992605
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1016/j.bbr.2005.02.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030996666
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1016/j.bbrc.2006.01.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043287561
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1016/j.biopsych.2008.02.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042756703
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1016/j.brainres.2006.05.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024606817
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1016/j.cell.2005.09.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024515362
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1016/j.cell.2008.01.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052266867
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1016/j.cell.2009.01.038 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010067908
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1016/j.conb.2010.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003561107
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1016/j.cub.2007.01.074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003693826
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.1016/j.expneurol.2005.08.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042625172
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.1016/j.expneurol.2005.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031510871
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.1016/j.expneurol.2007.10.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013196733
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.1016/j.expneurol.2009.07.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012860136
    438 rdf:type schema:CreativeWork
    439 https://doi.org/10.1016/j.expneurol.2010.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046953298
    440 rdf:type schema:CreativeWork
    441 https://doi.org/10.1016/j.gde.2003.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045251861
    442 rdf:type schema:CreativeWork
    443 https://doi.org/10.1016/j.jns.2006.05.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003549802
    444 rdf:type schema:CreativeWork
    445 https://doi.org/10.1016/j.nbd.2005.01.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051173079
    446 rdf:type schema:CreativeWork
    447 https://doi.org/10.1016/j.nbd.2005.08.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000552145
    448 rdf:type schema:CreativeWork
    449 https://doi.org/10.1016/j.nbd.2010.07.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052483631
    450 rdf:type schema:CreativeWork
    451 https://doi.org/10.1016/j.nbd.2010.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053262517
    452 rdf:type schema:CreativeWork
    453 https://doi.org/10.1016/j.nbd.2011.06.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003945438
    454 rdf:type schema:CreativeWork
    455 https://doi.org/10.1016/j.neuro.2004.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024756937
    456 rdf:type schema:CreativeWork
    457 https://doi.org/10.1016/j.neurobiolaging.2006.12.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004483763
    458 rdf:type schema:CreativeWork
    459 https://doi.org/10.1016/j.neurobiolaging.2009.11.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001181542
    460 rdf:type schema:CreativeWork
    461 https://doi.org/10.1016/j.neuron.2007.05.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049778354
    462 rdf:type schema:CreativeWork
    463 https://doi.org/10.1016/j.neuron.2010.04.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014420876
    464 rdf:type schema:CreativeWork
    465 https://doi.org/10.1016/j.neuron.2011.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006700754
    466 rdf:type schema:CreativeWork
    467 https://doi.org/10.1016/j.neuroscience.2003.10.040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006121140
    468 rdf:type schema:CreativeWork
    469 https://doi.org/10.1016/j.neuroscience.2004.11.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003512232
    470 rdf:type schema:CreativeWork
    471 https://doi.org/10.1016/j.neuroscience.2005.07.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014649204
    472 rdf:type schema:CreativeWork
    473 https://doi.org/10.1016/j.neuroscience.2007.11.036 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023885141
    474 rdf:type schema:CreativeWork
    475 https://doi.org/10.1016/j.neuroscience.2008.06.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019810758
    476 rdf:type schema:CreativeWork
    477 https://doi.org/10.1016/j.neuroscience.2010.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043918363
    478 rdf:type schema:CreativeWork
    479 https://doi.org/10.1016/j.neuroscience.2011.06.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039025427
    480 rdf:type schema:CreativeWork
    481 https://doi.org/10.1016/j.pneurobio.2005.01.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034071204
    482 rdf:type schema:CreativeWork
    483 https://doi.org/10.1016/j.stem.2007.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019220375
    484 rdf:type schema:CreativeWork
    485 https://doi.org/10.1016/j.stem.2010.03.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037118397
    486 rdf:type schema:CreativeWork
    487 https://doi.org/10.1016/j.stem.2011.09.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026017635
    488 rdf:type schema:CreativeWork
    489 https://doi.org/10.1016/j.tins.2010.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037144630
    490 rdf:type schema:CreativeWork
    491 https://doi.org/10.1016/s0014-2999(00)00904-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027618359
    492 rdf:type schema:CreativeWork
    493 https://doi.org/10.1016/s0092-8674(00)80783-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024856119
    494 rdf:type schema:CreativeWork
    495 https://doi.org/10.1016/s0092-8674(02)00862-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022579954
    496 rdf:type schema:CreativeWork
    497 https://doi.org/10.1016/s0166-4328(01)00309-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018056372
    498 rdf:type schema:CreativeWork
    499 https://doi.org/10.1016/s0197-4580(02)00065-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016528708
    500 rdf:type schema:CreativeWork
    501 https://doi.org/10.1016/s0278-5846(96)00157-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011715531
    502 rdf:type schema:CreativeWork
    503 https://doi.org/10.1016/s0306-4522(03)00036-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028605101
    504 rdf:type schema:CreativeWork
    505 https://doi.org/10.1016/s0306-4522(96)00545-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051529664
    506 rdf:type schema:CreativeWork
    507 https://doi.org/10.1016/s0306-4522(98)00693-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027482892
    508 rdf:type schema:CreativeWork
    509 https://doi.org/10.1016/s0896-6273(00)80886-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014547650
    510 rdf:type schema:CreativeWork
    511 https://doi.org/10.1016/s1474-4422(09)70062-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027860940
    512 rdf:type schema:CreativeWork
    513 https://doi.org/10.1037/0735-7044.118.5.1033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024016656
    514 rdf:type schema:CreativeWork
    515 https://doi.org/10.1038/mt.2010.115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047778765
    516 rdf:type schema:CreativeWork
    517 https://doi.org/10.1046/j.1460-9568.2002.02062.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003467834
    518 rdf:type schema:CreativeWork
    519 https://doi.org/10.1046/j.1460-9568.2002.02238.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012792359
    520 rdf:type schema:CreativeWork
    521 https://doi.org/10.1073/pnas.0401229101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047498883
    522 rdf:type schema:CreativeWork
    523 https://doi.org/10.1073/pnas.0406283101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043381340
    524 rdf:type schema:CreativeWork
    525 https://doi.org/10.1073/pnas.0710156104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009659022
    526 rdf:type schema:CreativeWork
    527 https://doi.org/10.1073/pnas.0803955106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010056299
    528 rdf:type schema:CreativeWork
    529 https://doi.org/10.1073/pnas.0903691106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001886419
    530 rdf:type schema:CreativeWork
    531 https://doi.org/10.1073/pnas.1005005107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003691723
    532 rdf:type schema:CreativeWork
    533 https://doi.org/10.1073/pnas.1100976108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016661335
    534 rdf:type schema:CreativeWork
    535 https://doi.org/10.1073/pnas.1131955100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015687983
    536 rdf:type schema:CreativeWork
    537 https://doi.org/10.1073/pnas.172514599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034504325
    538 rdf:type schema:CreativeWork
    539 https://doi.org/10.1073/pnas.96.23.13427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039908074
    540 rdf:type schema:CreativeWork
    541 https://doi.org/10.1073/pnas.97.2.571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038902993
    542 rdf:type schema:CreativeWork
    543 https://doi.org/10.1074/jbc.m109.081125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046013237
    544 rdf:type schema:CreativeWork
    545 https://doi.org/10.1089/scd.2006.15.407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059309593
    546 rdf:type schema:CreativeWork
    547 https://doi.org/10.1093/brain/awr256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049189230
    548 rdf:type schema:CreativeWork
    549 https://doi.org/10.1093/jnen/60.8.741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037432905
    550 rdf:type schema:CreativeWork
    551 https://doi.org/10.1093/jnen/63.11.1155 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029003422
    552 rdf:type schema:CreativeWork
    553 https://doi.org/10.1096/fj.06-6183com schema:sameAs https://app.dimensions.ai/details/publication/pub.1034098367
    554 rdf:type schema:CreativeWork
    555 https://doi.org/10.1096/fj.09-151456 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049819700
    556 rdf:type schema:CreativeWork
    557 https://doi.org/10.1097/00001756-200508010-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036320293
    558 rdf:type schema:CreativeWork
    559 https://doi.org/10.1097/nen.0b013e3181630cff schema:sameAs https://app.dimensions.ai/details/publication/pub.1032847388
    560 rdf:type schema:CreativeWork
    561 https://doi.org/10.1111/j.1460-9568.2004.03486.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012110749
    562 rdf:type schema:CreativeWork
    563 https://doi.org/10.1111/j.1460-9568.2009.06641.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045439552
    564 rdf:type schema:CreativeWork
    565 https://doi.org/10.1111/j.1460-9568.2011.07604.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050090562
    566 rdf:type schema:CreativeWork
    567 https://doi.org/10.1111/j.1460-9568.2011.07933.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005690450
    568 rdf:type schema:CreativeWork
    569 https://doi.org/10.1111/j.1471-4159.2004.02378.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024440300
    570 rdf:type schema:CreativeWork
    571 https://doi.org/10.1111/j.1471-4159.2004.02823.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021301013
    572 rdf:type schema:CreativeWork
    573 https://doi.org/10.1111/j.1471-4159.2005.03073.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009728373
    574 rdf:type schema:CreativeWork
    575 https://doi.org/10.1111/j.1471-4159.2009.06324.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048340670
    576 rdf:type schema:CreativeWork
    577 https://doi.org/10.1111/j.1471-4159.2010.06727.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032411594
    578 rdf:type schema:CreativeWork
    579 https://doi.org/10.1126/science.1083328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023861505
    580 rdf:type schema:CreativeWork
    581 https://doi.org/10.1126/science.1136281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062455025
    582 rdf:type schema:CreativeWork
    583 https://doi.org/10.1126/science.1173215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038374449
    584 rdf:type schema:CreativeWork
    585 https://doi.org/10.1126/science.271.5251.978 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062552258
    586 rdf:type schema:CreativeWork
    587 https://doi.org/10.1126/science.274.5293.1678 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062555128
    588 rdf:type schema:CreativeWork
    589 https://doi.org/10.1126/science.287.5456.1265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051109253
    590 rdf:type schema:CreativeWork
    591 https://doi.org/10.1126/science.6823561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062640856
    592 rdf:type schema:CreativeWork
    593 https://doi.org/10.1126/science.8178174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062653055
    594 rdf:type schema:CreativeWork
    595 https://doi.org/10.1146/annurev.cellbio.042308.113256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000621893
    596 rdf:type schema:CreativeWork
    597 https://doi.org/10.1152/jn.00076.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052172882
    598 rdf:type schema:CreativeWork
    599 https://doi.org/10.1159/000017427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018245728
    600 rdf:type schema:CreativeWork
    601 https://doi.org/10.1161/strokeaha.111.627802 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028283670
    602 rdf:type schema:CreativeWork
    603 https://doi.org/10.1212/wnl.0b013e318198dace schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354261
    604 rdf:type schema:CreativeWork
    605 https://doi.org/10.1212/wnl.0b013e3181f39d0e schema:sameAs https://app.dimensions.ai/details/publication/pub.1064355585
    606 rdf:type schema:CreativeWork
    607 https://doi.org/10.1371/journal.pbio.1000373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039238056
    608 rdf:type schema:CreativeWork
    609 https://doi.org/10.1371/journal.pone.0007017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036787337
    610 rdf:type schema:CreativeWork
    611 https://doi.org/10.1371/journal.pone.0009260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039984154
    612 rdf:type schema:CreativeWork
    613 https://doi.org/10.1523/jneurosci.0066-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010728508
    614 rdf:type schema:CreativeWork
    615 https://doi.org/10.1523/jneurosci.0237-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036399703
    616 rdf:type schema:CreativeWork
    617 https://doi.org/10.1523/jneurosci.0363-11.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013074362
    618 rdf:type schema:CreativeWork
    619 https://doi.org/10.1523/jneurosci.0618-11.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047391712
    620 rdf:type schema:CreativeWork
    621 https://doi.org/10.1523/jneurosci.0837-06.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015950085
    622 rdf:type schema:CreativeWork
    623 https://doi.org/10.1523/jneurosci.1120-05.2005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004445309
    624 rdf:type schema:CreativeWork
    625 https://doi.org/10.1523/jneurosci.1197-11.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028658897
    626 rdf:type schema:CreativeWork
    627 https://doi.org/10.1523/jneurosci.15-06-04687.1995 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082509055
    628 rdf:type schema:CreativeWork
    629 https://doi.org/10.1523/jneurosci.16-06-02027.1996 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082877022
    630 rdf:type schema:CreativeWork
    631 https://doi.org/10.1523/jneurosci.17-10-03727.1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083083006
    632 rdf:type schema:CreativeWork
    633 https://doi.org/10.1523/jneurosci.17-13-05046.1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083103223
    634 rdf:type schema:CreativeWork
    635 https://doi.org/10.1523/jneurosci.17-15-05820.1997 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083117119
    636 rdf:type schema:CreativeWork
    637 https://doi.org/10.1523/jneurosci.20-24-09104.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074740264
    638 rdf:type schema:CreativeWork
    639 https://doi.org/10.1523/jneurosci.22-03-00629.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074991982
    640 rdf:type schema:CreativeWork
    641 https://doi.org/10.1523/jneurosci.22-15-06639.2002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075096819
    642 rdf:type schema:CreativeWork
    643 https://doi.org/10.1523/jneurosci.2406-09.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046356947
    644 rdf:type schema:CreativeWork
    645 https://doi.org/10.1523/jneurosci.2617-07.2007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038587662
    646 rdf:type schema:CreativeWork
    647 https://doi.org/10.1523/jneurosci.2633-06.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015647415
    648 rdf:type schema:CreativeWork
    649 https://doi.org/10.1523/jneurosci.2954-08.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042940144
    650 rdf:type schema:CreativeWork
    651 https://doi.org/10.1523/jneurosci.3040-07.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042052449
    652 rdf:type schema:CreativeWork
    653 https://doi.org/10.1523/jneurosci.4859-05.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003220887
    654 rdf:type schema:CreativeWork
    655 https://doi.org/10.1523/jneurosci.4913-10.2011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028795454
    656 rdf:type schema:CreativeWork
    657 https://doi.org/10.1634/stemcells.2005-0281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016519185
    658 rdf:type schema:CreativeWork
    659 https://doi.org/10.1667/rr3206 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068196281
    660 rdf:type schema:CreativeWork
    661 https://doi.org/10.3389/fnbeh.2010.00176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035581831
    662 rdf:type schema:CreativeWork
    663 https://doi.org/10.3389/neuro.22.003.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001827965
    664 rdf:type schema:CreativeWork
    665 https://www.grid.ac/institutes/grid.411668.c schema:alternateName Universitätsklinikum Erlangen
    666 schema:name Department of Molecular Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany
    667 Department of Neurology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany
    668 Department of Neurosciences, University of California, San Diego 9500 Gilman Drive, 92093-0662, La Jolla, CA, USA
    669 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...