Regulation of Parkin E3 ubiquitin ligase activity View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-09

AUTHORS

Helen Walden, R. Julio Martinez-Torres

ABSTRACT

Parkin is an E3 ubiquitin ligase mutated in autosomal recessive juvenile Parkinson's disease. In addition, it is a putative tumour suppressor, and has roles outside its enzymatic activity. It is critical for mitochondrial clearance through mitophagy, and is an essential protein in most eukaryotes. As such, it is a tightly controlled protein, regulated through an array of external interactions with multiple proteins, posttranslational modifications including phosphorylation and S-nitrosylation, and self-regulation through internal associations. In this review, we highlight some of the recent studies into Parkin regulation and discuss future challenges for gaining a full molecular understanding of the regulation of Parkin E3 ligase activity. More... »

PAGES

3053-3067

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00018-012-0978-5

    DOI

    http://dx.doi.org/10.1007/s00018-012-0978-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004866741

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22527713


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