R432 is a key residue for the multiple functions of Ndt80p in Candida albicans View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10-16

AUTHORS

Yun Liang Yang, Chih Wei Wang, Shiang Ning Leaw, Te Pin Chang, I Chin Wang, Chia Geun Chen, Jen Chung Fan, Kuo Yun Tseng, Szu Hsuan Huang, Chih Yu Chen, Ting Yin Hsiao, Chao Agnes Hsiung, Chiung Tong Chen, Chwan Deng Hsiao, Hsiu Jung Lo

ABSTRACT

Ndt80p is an important transcription modulator to various stress-response genes in Candida albicans, the most common human fungal pathogen in systemic infections. We found that Ndt80p directly regulated its target genes, such as YHB1, via the mid-sporulation element (MSE). Furthermore, the ndt80R432A allele, with a reduced capability to bind MSE, failed to complement the defects caused by null mutations of NDT80. Thus, the R432 residue in the Ndt80p DNA-binding domain is involved in all tested functions, including cell separation, drug resistance, nitric oxide inactivation, germ tube formation, hyphal growth, and virulence. Hence, the importance of the R432 residue suggests a novel approach for designing new antifungal drugs by blocking the interaction between Ndt80p and its targets. More... »

PAGES

1011-1023

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-011-0849-5

DOI

http://dx.doi.org/10.1007/s00018-011-0849-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002965618

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22002580


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