Notch and cancer: a double-edged sword View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2007-08-11

AUTHORS

U. Koch, F. Radtke

ABSTRACT

.The highly conserved Notch signaling pathway plays pleiotropic roles during embryonic development and is important for the regulation of selfrenewing tissues. The physiological functions of this signaling cascade range from stem cell maintenance and influencing cell fate decisions of barely differentiated progenitor cells, to the induction of terminal differentiation processes, all of which have been found to be recapitulated in different forms of cancers. Although Notch signaling has mostly been associated with oncogenic and growth-promoting roles, depending on the tissue type it can also function as a tumor suppressor. Here we describe recent findings on Notch signaling in cancer and tumor angiogenesis, and highlight some of the therapeutic approaches that are currently being developed to interfere with tumor growth and progression. More... »

PAGES

2746-2762

Journal

TITLE

Cellular and Molecular Life Sciences

ISSUE

21

VOLUME

64

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00018-007-7164-1

    DOI

    http://dx.doi.org/10.1007/s00018-007-7164-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040206583

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17687513


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