Interferon-alpha and transforming growth factor-β co-induce growth inhibition of human tumor cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-10

AUTHORS

S. Foser, I. Redwanz, M. Ebeling, C. W. Heizmann, U. Certa

ABSTRACT

A hallmark of resistance to type I interferons (IFNs) is the lack of antiproliferative responses. We show here that costimulation with IFN-alpha and transforming growth factor beta-1 (TGF-beta) potentiates antiproliferative activity in a sensitive (ME15) and resistant (D10) human melanoma cell line. A DNA microarray-based search for proliferation control genes involved that are cooperatively activated by IFN-alpha and TGF-beta, yielded 28 genes. Among these are the insulin-like growth factor-binding protein 3 (IGFBP3) and the calcium-binding protein S100A2; we demonstrate, that recombinant IGFBP3 protein is a potent growth inhibitor requiring TGF-beta activity. The antiproliferative activity of S100A2 is significantly enhanced by IFN-alpha in stably transfected ME15 or D10 cell lines. We show for the first time that IFN-alpha is a potent inducer of intracellular calcium release required for activation of S100A2. Our study provides a functional link between IFN-alpha and TGF-beta signaling and extends the function of IFN signaling to calcium-sensitive processes. More... »

PAGES

2387-2396

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-006-6256-7

DOI

http://dx.doi.org/10.1007/s00018-006-6256-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009723904

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16988787


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotactic Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Like Growth Factor Binding Protein 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "S100 Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Roche (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.417570.0", 
          "name": [
            "Roche Center for Medical Genomics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foser", 
        "givenName": "S.", 
        "id": "sg:person.01044061460.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044061460.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.417570.0", 
          "name": [
            "Roche Center for Medical Genomics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Redwanz", 
        "givenName": "I.", 
        "id": "sg:person.01307672724.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307672724.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.417570.0", 
          "name": [
            "Department of Bioinformatics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ebeling", 
        "givenName": "M.", 
        "id": "sg:person.01251237146.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251237146.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Zurich", 
          "id": "https://www.grid.ac/institutes/grid.7400.3", 
          "name": [
            "Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstr. 75, 8032, Z\u00fcrich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heizmann", 
        "givenName": "C. W.", 
        "id": "sg:person.01257747106.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257747106.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.417570.0", 
          "name": [
            "Roche Center for Medical Genomics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Certa", 
        "givenName": "U.", 
        "id": "sg:person.01163441175.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163441175.70"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2006-10", 
    "datePublishedReg": "2006-10-01", 
    "description": "A hallmark of resistance to type I interferons (IFNs) is the lack of antiproliferative responses. We show here that costimulation with IFN-alpha and transforming growth factor beta-1 (TGF-beta) potentiates antiproliferative activity in a sensitive (ME15) and resistant (D10) human melanoma cell line. A DNA microarray-based search for proliferation control genes involved that are cooperatively activated by IFN-alpha and TGF-beta, yielded 28 genes. Among these are the insulin-like growth factor-binding protein 3 (IGFBP3) and the calcium-binding protein S100A2; we demonstrate, that recombinant IGFBP3 protein is a potent growth inhibitor requiring TGF-beta activity. The antiproliferative activity of S100A2 is significantly enhanced by IFN-alpha in stably transfected ME15 or D10 cell lines. We show for the first time that IFN-alpha is a potent inducer of intracellular calcium release required for activation of S100A2. Our study provides a functional link between IFN-alpha and TGF-beta signaling and extends the function of IFN signaling to calcium-sensitive processes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00018-006-6256-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295005", 
        "issn": [
          "1420-682X", 
          "1420-9071"
        ], 
        "name": "Cellular and Molecular Life Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "19-20", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "63"
      }
    ], 
    "name": "Interferon-alpha and transforming growth factor-\u03b2 co-induce growth inhibition of human tumor cells", 
    "pagination": "2387-2396", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2e52b80fdbdf6d5d9cc82e09041346220a6cba6ba3f127f919bef6904625e313"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16988787"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9705402"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00018-006-6256-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009723904"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00018-006-6256-7", 
      "https://app.dimensions.ai/details/publication/pub.1009723904"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000494.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00018-006-6256-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00018-006-6256-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00018-006-6256-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00018-006-6256-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00018-006-6256-7'


 

This table displays all metadata directly associated to this object as RDF triples.

165 TRIPLES      20 PREDICATES      45 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00018-006-6256-7 schema:about N03d867c3e1ac4386a50c97cd99f6bc19
2 N0bedcf17623d4918b9e41755b29f6db6
3 N35cde5d9c9d44c3baabd807e8a4746f9
4 N35f502a27da74be5982d75a561577220
5 N36a040f56fcb4980ae43512bafa0b666
6 N55183c03153645bea798386d5f8fcbbd
7 N754b5d7c244148568edec0dc1bb5500a
8 N7a6902ecdc1e4b8fb6da2ebfb2f714e8
9 N9e8c37f7ad874fb38418faa581c18990
10 Nb2cb3eb2548a4750b005d92e23a81c3f
11 Nc58536a1ca1f44d8884cd2f1cb2c75d7
12 Ncfca106f193549e58de96e98879f8bd4
13 Nd9508013ffa347efb8200af46a2e2549
14 Nd9a470ef6d87475b80afe58f7d024be3
15 Nf02a1d5d7b61446dbd09235333faebb9
16 Nfabf69530b7d43bd8268961c6ba72990
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author Nec5dc256d02143cc8520896a1ec95e8a
20 schema:datePublished 2006-10
21 schema:datePublishedReg 2006-10-01
22 schema:description A hallmark of resistance to type I interferons (IFNs) is the lack of antiproliferative responses. We show here that costimulation with IFN-alpha and transforming growth factor beta-1 (TGF-beta) potentiates antiproliferative activity in a sensitive (ME15) and resistant (D10) human melanoma cell line. A DNA microarray-based search for proliferation control genes involved that are cooperatively activated by IFN-alpha and TGF-beta, yielded 28 genes. Among these are the insulin-like growth factor-binding protein 3 (IGFBP3) and the calcium-binding protein S100A2; we demonstrate, that recombinant IGFBP3 protein is a potent growth inhibitor requiring TGF-beta activity. The antiproliferative activity of S100A2 is significantly enhanced by IFN-alpha in stably transfected ME15 or D10 cell lines. We show for the first time that IFN-alpha is a potent inducer of intracellular calcium release required for activation of S100A2. Our study provides a functional link between IFN-alpha and TGF-beta signaling and extends the function of IFN signaling to calcium-sensitive processes.
23 schema:genre research_article
24 schema:inLanguage en
25 schema:isAccessibleForFree false
26 schema:isPartOf Nd7ed4d937ba84fe5995ee87011501a5b
27 Nf891ab2db67c4264ac35e5b0f96773e5
28 sg:journal.1295005
29 schema:name Interferon-alpha and transforming growth factor-β co-induce growth inhibition of human tumor cells
30 schema:pagination 2387-2396
31 schema:productId N0e82a81579d1424882737b7012262222
32 N10dc672d74cc49d1823c4197c825df07
33 N3d5ef10bf4f24fc08452689db0affd06
34 Na7c7fa1c5edc4e8f90d654fba33b77b4
35 Nf9a5a50400c54e68b5263a8b164b8569
36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009723904
37 https://doi.org/10.1007/s00018-006-6256-7
38 schema:sdDatePublished 2019-04-11T01:03
39 schema:sdLicense https://scigraph.springernature.com/explorer/license/
40 schema:sdPublisher N656c743385014d3f8d935e0420b9576a
41 schema:url http://link.springer.com/10.1007/s00018-006-6256-7
42 sgo:license sg:explorer/license/
43 sgo:sdDataset articles
44 rdf:type schema:ScholarlyArticle
45 N03d867c3e1ac4386a50c97cd99f6bc19 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
46 schema:name Cell Line, Tumor
47 rdf:type schema:DefinedTerm
48 N07508fe48e9743d1a7681660690a7dba rdf:first sg:person.01257747106.47
49 rdf:rest Ned88fc3ed7c14e33bf64486da145309c
50 N0bedcf17623d4918b9e41755b29f6db6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
51 schema:name Gene Expression Regulation
52 rdf:type schema:DefinedTerm
53 N0e82a81579d1424882737b7012262222 schema:name dimensions_id
54 schema:value pub.1009723904
55 rdf:type schema:PropertyValue
56 N10dc672d74cc49d1823c4197c825df07 schema:name doi
57 schema:value 10.1007/s00018-006-6256-7
58 rdf:type schema:PropertyValue
59 N35cde5d9c9d44c3baabd807e8a4746f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Insulin-Like Growth Factor Binding Protein 3
61 rdf:type schema:DefinedTerm
62 N35f502a27da74be5982d75a561577220 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
63 schema:name Melanoma
64 rdf:type schema:DefinedTerm
65 N36a040f56fcb4980ae43512bafa0b666 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Chemotactic Factors
67 rdf:type schema:DefinedTerm
68 N388ab978cd5a450983fb3cb8b81ea82d rdf:first sg:person.01251237146.86
69 rdf:rest N07508fe48e9743d1a7681660690a7dba
70 N3d5ef10bf4f24fc08452689db0affd06 schema:name nlm_unique_id
71 schema:value 9705402
72 rdf:type schema:PropertyValue
73 N55183c03153645bea798386d5f8fcbbd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Drug Resistance, Neoplasm
75 rdf:type schema:DefinedTerm
76 N656c743385014d3f8d935e0420b9576a schema:name Springer Nature - SN SciGraph project
77 rdf:type schema:Organization
78 N754b5d7c244148568edec0dc1bb5500a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Transforming Growth Factor beta
80 rdf:type schema:DefinedTerm
81 N7a6902ecdc1e4b8fb6da2ebfb2f714e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Interferon-alpha
83 rdf:type schema:DefinedTerm
84 N85ee7737090243c1bd302ddcaa5125b4 rdf:first sg:person.01307672724.47
85 rdf:rest N388ab978cd5a450983fb3cb8b81ea82d
86 N9e8c37f7ad874fb38418faa581c18990 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Gene Expression Profiling
88 rdf:type schema:DefinedTerm
89 Na7c7fa1c5edc4e8f90d654fba33b77b4 schema:name pubmed_id
90 schema:value 16988787
91 rdf:type schema:PropertyValue
92 Nb2cb3eb2548a4750b005d92e23a81c3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Genomics
94 rdf:type schema:DefinedTerm
95 Nc58536a1ca1f44d8884cd2f1cb2c75d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Antineoplastic Agents
97 rdf:type schema:DefinedTerm
98 Ncfca106f193549e58de96e98879f8bd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Humans
100 rdf:type schema:DefinedTerm
101 Nd7ed4d937ba84fe5995ee87011501a5b schema:issueNumber 19-20
102 rdf:type schema:PublicationIssue
103 Nd9508013ffa347efb8200af46a2e2549 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name S100 Proteins
105 rdf:type schema:DefinedTerm
106 Nd9a470ef6d87475b80afe58f7d024be3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Oligonucleotide Array Sequence Analysis
108 rdf:type schema:DefinedTerm
109 Nec5dc256d02143cc8520896a1ec95e8a rdf:first sg:person.01044061460.49
110 rdf:rest N85ee7737090243c1bd302ddcaa5125b4
111 Ned88fc3ed7c14e33bf64486da145309c rdf:first sg:person.01163441175.70
112 rdf:rest rdf:nil
113 Nf02a1d5d7b61446dbd09235333faebb9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Cell Proliferation
115 rdf:type schema:DefinedTerm
116 Nf891ab2db67c4264ac35e5b0f96773e5 schema:volumeNumber 63
117 rdf:type schema:PublicationVolume
118 Nf9a5a50400c54e68b5263a8b164b8569 schema:name readcube_id
119 schema:value 2e52b80fdbdf6d5d9cc82e09041346220a6cba6ba3f127f919bef6904625e313
120 rdf:type schema:PropertyValue
121 Nfabf69530b7d43bd8268961c6ba72990 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Signal Transduction
123 rdf:type schema:DefinedTerm
124 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
125 schema:name Biological Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
128 schema:name Biochemistry and Cell Biology
129 rdf:type schema:DefinedTerm
130 sg:journal.1295005 schema:issn 1420-682X
131 1420-9071
132 schema:name Cellular and Molecular Life Sciences
133 rdf:type schema:Periodical
134 sg:person.01044061460.49 schema:affiliation https://www.grid.ac/institutes/grid.417570.0
135 schema:familyName Foser
136 schema:givenName S.
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044061460.49
138 rdf:type schema:Person
139 sg:person.01163441175.70 schema:affiliation https://www.grid.ac/institutes/grid.417570.0
140 schema:familyName Certa
141 schema:givenName U.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163441175.70
143 rdf:type schema:Person
144 sg:person.01251237146.86 schema:affiliation https://www.grid.ac/institutes/grid.417570.0
145 schema:familyName Ebeling
146 schema:givenName M.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251237146.86
148 rdf:type schema:Person
149 sg:person.01257747106.47 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
150 schema:familyName Heizmann
151 schema:givenName C. W.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257747106.47
153 rdf:type schema:Person
154 sg:person.01307672724.47 schema:affiliation https://www.grid.ac/institutes/grid.417570.0
155 schema:familyName Redwanz
156 schema:givenName I.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307672724.47
158 rdf:type schema:Person
159 https://www.grid.ac/institutes/grid.417570.0 schema:alternateName Roche (Switzerland)
160 schema:name Department of Bioinformatics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland
161 Roche Center for Medical Genomics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland
162 rdf:type schema:Organization
163 https://www.grid.ac/institutes/grid.7400.3 schema:alternateName University of Zurich
164 schema:name Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstr. 75, 8032, Zürich, Switzerland
165 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...