Interferon-alpha and transforming growth factor-β co-induce growth inhibition of human tumor cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-10

AUTHORS

S. Foser, I. Redwanz, M. Ebeling, C. W. Heizmann, U. Certa

ABSTRACT

A hallmark of resistance to type I interferons (IFNs) is the lack of antiproliferative responses. We show here that costimulation with IFN-alpha and transforming growth factor beta-1 (TGF-beta) potentiates antiproliferative activity in a sensitive (ME15) and resistant (D10) human melanoma cell line. A DNA microarray-based search for proliferation control genes involved that are cooperatively activated by IFN-alpha and TGF-beta, yielded 28 genes. Among these are the insulin-like growth factor-binding protein 3 (IGFBP3) and the calcium-binding protein S100A2; we demonstrate, that recombinant IGFBP3 protein is a potent growth inhibitor requiring TGF-beta activity. The antiproliferative activity of S100A2 is significantly enhanced by IFN-alpha in stably transfected ME15 or D10 cell lines. We show for the first time that IFN-alpha is a potent inducer of intracellular calcium release required for activation of S100A2. Our study provides a functional link between IFN-alpha and TGF-beta signaling and extends the function of IFN signaling to calcium-sensitive processes. More... »

PAGES

2387-2396

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-006-6256-7

DOI

http://dx.doi.org/10.1007/s00018-006-6256-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009723904

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16988787


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotactic Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Resistance, Neoplasm", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Profiling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Like Growth Factor Binding Protein 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oligonucleotide Array Sequence Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "S100 Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Signal Transduction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Roche (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.417570.0", 
          "name": [
            "Roche Center for Medical Genomics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foser", 
        "givenName": "S.", 
        "id": "sg:person.01044061460.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044061460.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.417570.0", 
          "name": [
            "Roche Center for Medical Genomics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Redwanz", 
        "givenName": "I.", 
        "id": "sg:person.01307672724.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307672724.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.417570.0", 
          "name": [
            "Department of Bioinformatics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ebeling", 
        "givenName": "M.", 
        "id": "sg:person.01251237146.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251237146.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Zurich", 
          "id": "https://www.grid.ac/institutes/grid.7400.3", 
          "name": [
            "Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstr. 75, 8032, Z\u00fcrich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heizmann", 
        "givenName": "C. W.", 
        "id": "sg:person.01257747106.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257747106.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Roche (Switzerland)", 
          "id": "https://www.grid.ac/institutes/grid.417570.0", 
          "name": [
            "Roche Center for Medical Genomics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Certa", 
        "givenName": "U.", 
        "id": "sg:person.01163441175.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163441175.70"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2006-10", 
    "datePublishedReg": "2006-10-01", 
    "description": "A hallmark of resistance to type I interferons (IFNs) is the lack of antiproliferative responses. We show here that costimulation with IFN-alpha and transforming growth factor beta-1 (TGF-beta) potentiates antiproliferative activity in a sensitive (ME15) and resistant (D10) human melanoma cell line. A DNA microarray-based search for proliferation control genes involved that are cooperatively activated by IFN-alpha and TGF-beta, yielded 28 genes. Among these are the insulin-like growth factor-binding protein 3 (IGFBP3) and the calcium-binding protein S100A2; we demonstrate, that recombinant IGFBP3 protein is a potent growth inhibitor requiring TGF-beta activity. The antiproliferative activity of S100A2 is significantly enhanced by IFN-alpha in stably transfected ME15 or D10 cell lines. We show for the first time that IFN-alpha is a potent inducer of intracellular calcium release required for activation of S100A2. Our study provides a functional link between IFN-alpha and TGF-beta signaling and extends the function of IFN signaling to calcium-sensitive processes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00018-006-6256-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1295005", 
        "issn": [
          "1420-682X", 
          "1420-9071"
        ], 
        "name": "Cellular and Molecular Life Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "19-20", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "63"
      }
    ], 
    "name": "Interferon-alpha and transforming growth factor-\u03b2 co-induce growth inhibition of human tumor cells", 
    "pagination": "2387-2396", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "2e52b80fdbdf6d5d9cc82e09041346220a6cba6ba3f127f919bef6904625e313"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16988787"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9705402"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00018-006-6256-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009723904"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00018-006-6256-7", 
      "https://app.dimensions.ai/details/publication/pub.1009723904"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000494.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00018-006-6256-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00018-006-6256-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00018-006-6256-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00018-006-6256-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00018-006-6256-7'


 

This table displays all metadata directly associated to this object as RDF triples.

165 TRIPLES      20 PREDICATES      45 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00018-006-6256-7 schema:about N116fe99835dc462192aa2f337905b2d2
2 N16b0dc3ed7a34fbeb4e353a6132a35d6
3 N38ed046405b64046a3b94658ad3ddcd1
4 N3a5bafcb6a264c1aa52511c1bca54832
5 N3c001003d34347deb219ac437d6e96b2
6 N515af46946e143e89916191c79dd80b8
7 N5a414bc90f5441a3a7519724515cbd6c
8 N79770b12811049b4bfa922f2e564452a
9 Na6796d2beeaf4c089aacaab867ba23df
10 Na74c9b65bfd94482bf6e3ab9953665c0
11 Na7bd570968cd4bec85a003a403f5c939
12 Nad89186419b740ca8ffdd548da3a5ae4
13 Nd434509ad48b44aa91a21b10fdce8db6
14 Nd5d3ff0dfe0643bd964fe9646e524a46
15 Nd9c87de788cc477482a044690eab8093
16 Nfa253b97dc9f484bae32cf25e9042093
17 anzsrc-for:06
18 anzsrc-for:0601
19 schema:author N58c1ef5673174539bbeab315da67d6da
20 schema:datePublished 2006-10
21 schema:datePublishedReg 2006-10-01
22 schema:description A hallmark of resistance to type I interferons (IFNs) is the lack of antiproliferative responses. We show here that costimulation with IFN-alpha and transforming growth factor beta-1 (TGF-beta) potentiates antiproliferative activity in a sensitive (ME15) and resistant (D10) human melanoma cell line. A DNA microarray-based search for proliferation control genes involved that are cooperatively activated by IFN-alpha and TGF-beta, yielded 28 genes. Among these are the insulin-like growth factor-binding protein 3 (IGFBP3) and the calcium-binding protein S100A2; we demonstrate, that recombinant IGFBP3 protein is a potent growth inhibitor requiring TGF-beta activity. The antiproliferative activity of S100A2 is significantly enhanced by IFN-alpha in stably transfected ME15 or D10 cell lines. We show for the first time that IFN-alpha is a potent inducer of intracellular calcium release required for activation of S100A2. Our study provides a functional link between IFN-alpha and TGF-beta signaling and extends the function of IFN signaling to calcium-sensitive processes.
23 schema:genre research_article
24 schema:inLanguage en
25 schema:isAccessibleForFree false
26 schema:isPartOf N0af11ab309794910ba72d35fd4ab79e6
27 N1f4172ff161d4a018f3e94717edc3ff0
28 sg:journal.1295005
29 schema:name Interferon-alpha and transforming growth factor-β co-induce growth inhibition of human tumor cells
30 schema:pagination 2387-2396
31 schema:productId N00c71736ec0348939af7bcbb7daba81d
32 N1d0ffe27bc814e28b5463d29f0577fbd
33 N2d35b9c6939048c495d2effec1b9f072
34 N3e3eac54bb3f476e9a3f779156b45d52
35 N63bb43f124324714a8f2343f7ed6e5ce
36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009723904
37 https://doi.org/10.1007/s00018-006-6256-7
38 schema:sdDatePublished 2019-04-11T01:03
39 schema:sdLicense https://scigraph.springernature.com/explorer/license/
40 schema:sdPublisher Na754ca297df94d748d5f3b662e34fafd
41 schema:url http://link.springer.com/10.1007/s00018-006-6256-7
42 sgo:license sg:explorer/license/
43 sgo:sdDataset articles
44 rdf:type schema:ScholarlyArticle
45 N00c71736ec0348939af7bcbb7daba81d schema:name pubmed_id
46 schema:value 16988787
47 rdf:type schema:PropertyValue
48 N0af11ab309794910ba72d35fd4ab79e6 schema:issueNumber 19-20
49 rdf:type schema:PublicationIssue
50 N116fe99835dc462192aa2f337905b2d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
51 schema:name Gene Expression Profiling
52 rdf:type schema:DefinedTerm
53 N15f12c2ae2f046a29e1aaba4a539d293 rdf:first sg:person.01251237146.86
54 rdf:rest N64293ff005a049a9a1b1b25d568cd34c
55 N16b0dc3ed7a34fbeb4e353a6132a35d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
56 schema:name S100 Proteins
57 rdf:type schema:DefinedTerm
58 N1d0ffe27bc814e28b5463d29f0577fbd schema:name dimensions_id
59 schema:value pub.1009723904
60 rdf:type schema:PropertyValue
61 N1f4172ff161d4a018f3e94717edc3ff0 schema:volumeNumber 63
62 rdf:type schema:PublicationVolume
63 N2d35b9c6939048c495d2effec1b9f072 schema:name nlm_unique_id
64 schema:value 9705402
65 rdf:type schema:PropertyValue
66 N38ed046405b64046a3b94658ad3ddcd1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
67 schema:name Drug Resistance, Neoplasm
68 rdf:type schema:DefinedTerm
69 N3a5bafcb6a264c1aa52511c1bca54832 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Transforming Growth Factor beta
71 rdf:type schema:DefinedTerm
72 N3c001003d34347deb219ac437d6e96b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Humans
74 rdf:type schema:DefinedTerm
75 N3e3eac54bb3f476e9a3f779156b45d52 schema:name readcube_id
76 schema:value 2e52b80fdbdf6d5d9cc82e09041346220a6cba6ba3f127f919bef6904625e313
77 rdf:type schema:PropertyValue
78 N515af46946e143e89916191c79dd80b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Oligonucleotide Array Sequence Analysis
80 rdf:type schema:DefinedTerm
81 N58c1ef5673174539bbeab315da67d6da rdf:first sg:person.01044061460.49
82 rdf:rest Nc222ffe9ef0e43e79a1d1df64271bfad
83 N5a414bc90f5441a3a7519724515cbd6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Cell Proliferation
85 rdf:type schema:DefinedTerm
86 N63bb43f124324714a8f2343f7ed6e5ce schema:name doi
87 schema:value 10.1007/s00018-006-6256-7
88 rdf:type schema:PropertyValue
89 N64293ff005a049a9a1b1b25d568cd34c rdf:first sg:person.01257747106.47
90 rdf:rest Na969f518e98d4accac7f3d96f3ea8db4
91 N79770b12811049b4bfa922f2e564452a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Chemotactic Factors
93 rdf:type schema:DefinedTerm
94 Na6796d2beeaf4c089aacaab867ba23df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Melanoma
96 rdf:type schema:DefinedTerm
97 Na74c9b65bfd94482bf6e3ab9953665c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Genomics
99 rdf:type schema:DefinedTerm
100 Na754ca297df94d748d5f3b662e34fafd schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 Na7bd570968cd4bec85a003a403f5c939 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Signal Transduction
104 rdf:type schema:DefinedTerm
105 Na969f518e98d4accac7f3d96f3ea8db4 rdf:first sg:person.01163441175.70
106 rdf:rest rdf:nil
107 Nad89186419b740ca8ffdd548da3a5ae4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Cell Line, Tumor
109 rdf:type schema:DefinedTerm
110 Nc222ffe9ef0e43e79a1d1df64271bfad rdf:first sg:person.01307672724.47
111 rdf:rest N15f12c2ae2f046a29e1aaba4a539d293
112 Nd434509ad48b44aa91a21b10fdce8db6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Gene Expression Regulation
114 rdf:type schema:DefinedTerm
115 Nd5d3ff0dfe0643bd964fe9646e524a46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Interferon-alpha
117 rdf:type schema:DefinedTerm
118 Nd9c87de788cc477482a044690eab8093 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Insulin-Like Growth Factor Binding Protein 3
120 rdf:type schema:DefinedTerm
121 Nfa253b97dc9f484bae32cf25e9042093 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Antineoplastic Agents
123 rdf:type schema:DefinedTerm
124 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
125 schema:name Biological Sciences
126 rdf:type schema:DefinedTerm
127 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
128 schema:name Biochemistry and Cell Biology
129 rdf:type schema:DefinedTerm
130 sg:journal.1295005 schema:issn 1420-682X
131 1420-9071
132 schema:name Cellular and Molecular Life Sciences
133 rdf:type schema:Periodical
134 sg:person.01044061460.49 schema:affiliation https://www.grid.ac/institutes/grid.417570.0
135 schema:familyName Foser
136 schema:givenName S.
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01044061460.49
138 rdf:type schema:Person
139 sg:person.01163441175.70 schema:affiliation https://www.grid.ac/institutes/grid.417570.0
140 schema:familyName Certa
141 schema:givenName U.
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163441175.70
143 rdf:type schema:Person
144 sg:person.01251237146.86 schema:affiliation https://www.grid.ac/institutes/grid.417570.0
145 schema:familyName Ebeling
146 schema:givenName M.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251237146.86
148 rdf:type schema:Person
149 sg:person.01257747106.47 schema:affiliation https://www.grid.ac/institutes/grid.7400.3
150 schema:familyName Heizmann
151 schema:givenName C. W.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257747106.47
153 rdf:type schema:Person
154 sg:person.01307672724.47 schema:affiliation https://www.grid.ac/institutes/grid.417570.0
155 schema:familyName Redwanz
156 schema:givenName I.
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307672724.47
158 rdf:type schema:Person
159 https://www.grid.ac/institutes/grid.417570.0 schema:alternateName Roche (Switzerland)
160 schema:name Department of Bioinformatics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland
161 Roche Center for Medical Genomics, F. Hoffmann-La Roche AG, 4070, Basel, Switzerland
162 rdf:type schema:Organization
163 https://www.grid.ac/institutes/grid.7400.3 schema:alternateName University of Zurich
164 schema:name Division of Clinical Chemistry and Biochemistry, Department of Pediatrics, University of Zurich, Steinwiesstr. 75, 8032, Zürich, Switzerland
165 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...