Caenorhabditis elegans dpy-5 is a cuticle procollagen processed by a proprotein convertase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-05

AUTHORS

C. Thacker, J. A. Sheps, A. M. Rose

ABSTRACT

Genetic analysis of the nematode Caenorhabditis elegans reveals that all dpy-5 alleles are dominant suppressors of bli-4 blistering. Molecular cloning of dpy-5 establishes that it encodes a cuticle procollagen, defects in which are responsible for the short-body, dumpy phenotype. The null mutation, e907 removes the entire coding region, whereas the dpy-5 reference allele, e61, contains a nonsense substitution. RT-PCR analysis and a dpy-5::gfp fusion show that dpy-5 is expressed only in hypodermal cells at all post-embryonic life-cycle stages. Variable expression of dpy-5 in V lineage-derived seam cells suggests an alternative regulatory mechanism in these cells. The dpy-5 gene product contains an Arg-X-X-Arg cleavage motif that could be recognized by a proprotein convertase, such as BLI-4. Mutation of this site cause a dominant dumpy phenotype suggesting Dpy-5 procollagen requires processing for normal cuticle production. More... »

PAGES

1193-1204

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-006-6012-z

DOI

http://dx.doi.org/10.1007/s00018-006-6012-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027216176

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16649143


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