Major contribution of codominant CD8 and CD4 T cell epitopes to the human cytomegalovirus-specific T cell repertoire View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-01

AUTHORS

M. -D. Nastke†, L. Herrgen†, S. Walter, D. Wernet, H. -G. Rammensee, S. Stevanović

ABSTRACT

Human cytomegalovirus (HCMV) infection or reactivation is a cause of morbidity and mortality in immunocompromised individuals. In immunocompetent individuals, in contrast, HCMV is successfully controlled by specific CD8 and CD4 T cells. Knowledge of CD8 and CD4 T cell epitopes from HCMV and their immunodominant features is crucial for the generation of epitope-specific T cells for adoptive immunotherapy and for the development of a peptide-based HCMV vaccine. Therefore, we investigated the natural frequencies of a large number of CD8 and CD4 T cell epitopes, including 10 novel ones. We determined several epitopes as immunodominant. Surprisingly, no clear hierarchies were found for CD8 T cell epitopes, indicating codominance. These results will be valuable for adoptive transfer strategies and support initiatives towards development of a peptide-based HCMV vaccine. More... »

PAGES

77-86

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-004-4363-x

DOI

http://dx.doi.org/10.1007/s00018-004-4363-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048792724

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15619009


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