Ontology type: schema:ScholarlyArticle
2005-01
AUTHORSM. -D. Nastke†, L. Herrgen†, S. Walter, D. Wernet, H. -G. Rammensee, S. Stevanović
ABSTRACTHuman cytomegalovirus (HCMV) infection or reactivation is a cause of morbidity and mortality in immunocompromised individuals. In immunocompetent individuals, in contrast, HCMV is successfully controlled by specific CD8 and CD4 T cells. Knowledge of CD8 and CD4 T cell epitopes from HCMV and their immunodominant features is crucial for the generation of epitope-specific T cells for adoptive immunotherapy and for the development of a peptide-based HCMV vaccine. Therefore, we investigated the natural frequencies of a large number of CD8 and CD4 T cell epitopes, including 10 novel ones. We determined several epitopes as immunodominant. Surprisingly, no clear hierarchies were found for CD8 T cell epitopes, indicating codominance. These results will be valuable for adoptive transfer strategies and support initiatives towards development of a peptide-based HCMV vaccine. More... »
PAGES77-86
http://scigraph.springernature.com/pub.10.1007/s00018-004-4363-x
DOIhttp://dx.doi.org/10.1007/s00018-004-4363-x
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15619009
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