The Wiskott-Aldrich syndrome View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-09

AUTHORS

J. S. Orange, K. D. Stone, S. E. Turvey, K. Krzewski

ABSTRACT

The Wiskott-Aldrich Syndrome (WAS) is an inherited immunodeficiency caused by a variety of mutations in the gene encoding the WAS protein (WASp). WASp is expressed in hematopoetic cells and facilitates the reorganization of the actin cytoskeleton in response to many important cell stimuli. Extensive study of WAS and more recently WASp has given great insight into the relevance of this molecule and related molecules to both basic cell biology and human immune defenses. More... »

PAGES

2361-2385

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-004-4086-z

DOI

http://dx.doi.org/10.1007/s00018-004-4086-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032626186

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15378206


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Platelets", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Eczema", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wiskott-Aldrich Syndrome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wiskott-Aldrich Syndrome Protein", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Division of Immunology, Children\u2019s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, 3615 Civic Center Blvd, 19104, Philadelphia, Pennsylvania, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Orange", 
        "givenName": "J. S.", 
        "id": "sg:person.0774334672.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774334672.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Immunology, Children\u2019s Hospital Boston, Department of Pediatrics, Harvard Medical School, 300 Longwood Ave., 02115, Boston, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stone", 
        "givenName": "K. D.", 
        "id": "sg:person.01024113700.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024113700.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of British Columbia", 
          "id": "https://www.grid.ac/institutes/grid.17091.3e", 
          "name": [
            "Division of Infections and Immunolocal Diseases, Department of Pediatrics, University of British Columbia, 317-2194 Health Sciences Mall, BC VT6123, Vacouver, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Turvey", 
        "givenName": "S. E.", 
        "id": "sg:person.0765661111.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765661111.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Harvard University", 
          "id": "https://www.grid.ac/institutes/grid.38142.3c", 
          "name": [
            "Department of Molecular and Cell Biology, Harvard University, 7 Divinity Ave., 02138, Cambridge, Massachusetts, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Krzewski", 
        "givenName": "K.", 
        "id": "sg:person.01346250200.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346250200.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0960-7404(03)00005-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006064453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-7404(03)00005-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006064453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-7819-6-117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010034034", 
          "https://doi.org/10.1186/1477-7819-6-117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5732/cjc.014.10048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012675414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.134.5.487", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017701477"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21037/jtd.2016.11.03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068833912"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-09", 
    "datePublishedReg": "2004-09-01", 
    "description": "The Wiskott-Aldrich Syndrome (WAS) is an inherited immunodeficiency caused by a variety of mutations in the gene encoding the WAS protein (WASp). WASp is expressed in hematopoetic cells and facilitates the reorganization of the actin cytoskeleton in response to many important cell stimuli. Extensive study of WAS and more recently WASp has given great insight into the relevance of this molecule and related molecules to both basic cell biology and human immune defenses.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00018-004-4086-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2410014", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295005", 
        "issn": [
          "1420-682X", 
          "1420-9071"
        ], 
        "name": "Cellular and Molecular Life Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "18", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "61"
      }
    ], 
    "name": "The Wiskott-Aldrich syndrome", 
    "pagination": "2361-2385", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9b6dc4534de16893d91becc098ae0a6f2a2133582e85089c4e6bca1692466142"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15378206"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9705402"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00018-004-4086-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032626186"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00018-004-4086-z", 
      "https://app.dimensions.ai/details/publication/pub.1032626186"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:05", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000496.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00018-004-4086-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00018-004-4086-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00018-004-4086-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00018-004-4086-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00018-004-4086-z'


 

This table displays all metadata directly associated to this object as RDF triples.

147 TRIPLES      21 PREDICATES      42 URIs      29 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00018-004-4086-z schema:about N00638e009dde48d3a3f5df2566265282
2 N0c4b7a5290454e4e8a97592f7987dd97
3 N0da4cee6cbd349de80de71ab387770ef
4 N1f70ae69d180484ea1f2ae8f87a77863
5 N264d2defc1744bbd8b1f2747d5978140
6 N83634e627c7b419998421e528f2f9756
7 N852f8b4ce5574ee7a0f5e704b8ff5d01
8 Neb54630b04bd485c93dd4a785d1e96fd
9 anzsrc-for:06
10 anzsrc-for:0601
11 schema:author N0169676e99994d4e99e9201d190ace6b
12 schema:citation sg:pub.10.1186/1477-7819-6-117
13 https://doi.org/10.1001/archsurg.134.5.487
14 https://doi.org/10.1016/s0960-7404(03)00005-7
15 https://doi.org/10.21037/jtd.2016.11.03
16 https://doi.org/10.5732/cjc.014.10048
17 schema:datePublished 2004-09
18 schema:datePublishedReg 2004-09-01
19 schema:description The Wiskott-Aldrich Syndrome (WAS) is an inherited immunodeficiency caused by a variety of mutations in the gene encoding the WAS protein (WASp). WASp is expressed in hematopoetic cells and facilitates the reorganization of the actin cytoskeleton in response to many important cell stimuli. Extensive study of WAS and more recently WASp has given great insight into the relevance of this molecule and related molecules to both basic cell biology and human immune defenses.
20 schema:genre research_article
21 schema:inLanguage en
22 schema:isAccessibleForFree false
23 schema:isPartOf N8806455d4e1e4d0c8a8864ba823e7b18
24 Nc761ebfe9b6441b4a35c473130d2df4c
25 sg:journal.1295005
26 schema:name The Wiskott-Aldrich syndrome
27 schema:pagination 2361-2385
28 schema:productId N38ecf7da014b4cb6a1114f7be01d26d2
29 N5295b139e1614e7690726595a68ac620
30 Nca983f4f3df3473fb2d5cc7ca2c4fb8b
31 Nd36236a031e5406188f590ba43ea0275
32 Ne5166493ebc24bb3b70e98f5e76c4b4b
33 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032626186
34 https://doi.org/10.1007/s00018-004-4086-z
35 schema:sdDatePublished 2019-04-10T19:05
36 schema:sdLicense https://scigraph.springernature.com/explorer/license/
37 schema:sdPublisher N32abb4aa08734b32b7729b8f65dce7ca
38 schema:url http://link.springer.com/10.1007/s00018-004-4086-z
39 sgo:license sg:explorer/license/
40 sgo:sdDataset articles
41 rdf:type schema:ScholarlyArticle
42 N00638e009dde48d3a3f5df2566265282 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
43 schema:name Humans
44 rdf:type schema:DefinedTerm
45 N0169676e99994d4e99e9201d190ace6b rdf:first sg:person.0774334672.45
46 rdf:rest N115116dcce7145f999fb43b3c429bd6e
47 N031cc86fe4f44753a7b3eea66365ac70 schema:name Division of Immunology, Children’s Hospital Boston, Department of Pediatrics, Harvard Medical School, 300 Longwood Ave., 02115, Boston, Massachusetts, USA
48 rdf:type schema:Organization
49 N0c4b7a5290454e4e8a97592f7987dd97 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
50 schema:name Genetic Therapy
51 rdf:type schema:DefinedTerm
52 N0da4cee6cbd349de80de71ab387770ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
53 schema:name Animals
54 rdf:type schema:DefinedTerm
55 N115116dcce7145f999fb43b3c429bd6e rdf:first sg:person.01024113700.28
56 rdf:rest N582b18d467b04b74a0d6b640e0871a5a
57 N1f70ae69d180484ea1f2ae8f87a77863 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
58 schema:name Wiskott-Aldrich Syndrome Protein
59 rdf:type schema:DefinedTerm
60 N264d2defc1744bbd8b1f2747d5978140 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
61 schema:name Wiskott-Aldrich Syndrome
62 rdf:type schema:DefinedTerm
63 N32abb4aa08734b32b7729b8f65dce7ca schema:name Springer Nature - SN SciGraph project
64 rdf:type schema:Organization
65 N38ecf7da014b4cb6a1114f7be01d26d2 schema:name readcube_id
66 schema:value 9b6dc4534de16893d91becc098ae0a6f2a2133582e85089c4e6bca1692466142
67 rdf:type schema:PropertyValue
68 N5295b139e1614e7690726595a68ac620 schema:name pubmed_id
69 schema:value 15378206
70 rdf:type schema:PropertyValue
71 N582b18d467b04b74a0d6b640e0871a5a rdf:first sg:person.0765661111.14
72 rdf:rest Nd48d099ea3fe425eac216c841ec80947
73 N83634e627c7b419998421e528f2f9756 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Eczema
75 rdf:type schema:DefinedTerm
76 N852f8b4ce5574ee7a0f5e704b8ff5d01 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Proteins
78 rdf:type schema:DefinedTerm
79 N8806455d4e1e4d0c8a8864ba823e7b18 schema:issueNumber 18
80 rdf:type schema:PublicationIssue
81 Nc761ebfe9b6441b4a35c473130d2df4c schema:volumeNumber 61
82 rdf:type schema:PublicationVolume
83 Nca983f4f3df3473fb2d5cc7ca2c4fb8b schema:name dimensions_id
84 schema:value pub.1032626186
85 rdf:type schema:PropertyValue
86 Nd36236a031e5406188f590ba43ea0275 schema:name doi
87 schema:value 10.1007/s00018-004-4086-z
88 rdf:type schema:PropertyValue
89 Nd48d099ea3fe425eac216c841ec80947 rdf:first sg:person.01346250200.66
90 rdf:rest rdf:nil
91 Ne2e35d5467654986ac44c49b82fd339e schema:name Division of Immunology, Children’s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, 3615 Civic Center Blvd, 19104, Philadelphia, Pennsylvania, USA
92 rdf:type schema:Organization
93 Ne5166493ebc24bb3b70e98f5e76c4b4b schema:name nlm_unique_id
94 schema:value 9705402
95 rdf:type schema:PropertyValue
96 Neb54630b04bd485c93dd4a785d1e96fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Blood Platelets
98 rdf:type schema:DefinedTerm
99 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
100 schema:name Biological Sciences
101 rdf:type schema:DefinedTerm
102 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
103 schema:name Biochemistry and Cell Biology
104 rdf:type schema:DefinedTerm
105 sg:grant.2410014 http://pending.schema.org/fundedItem sg:pub.10.1007/s00018-004-4086-z
106 rdf:type schema:MonetaryGrant
107 sg:journal.1295005 schema:issn 1420-682X
108 1420-9071
109 schema:name Cellular and Molecular Life Sciences
110 rdf:type schema:Periodical
111 sg:person.01024113700.28 schema:affiliation N031cc86fe4f44753a7b3eea66365ac70
112 schema:familyName Stone
113 schema:givenName K. D.
114 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024113700.28
115 rdf:type schema:Person
116 sg:person.01346250200.66 schema:affiliation https://www.grid.ac/institutes/grid.38142.3c
117 schema:familyName Krzewski
118 schema:givenName K.
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346250200.66
120 rdf:type schema:Person
121 sg:person.0765661111.14 schema:affiliation https://www.grid.ac/institutes/grid.17091.3e
122 schema:familyName Turvey
123 schema:givenName S. E.
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0765661111.14
125 rdf:type schema:Person
126 sg:person.0774334672.45 schema:affiliation Ne2e35d5467654986ac44c49b82fd339e
127 schema:familyName Orange
128 schema:givenName J. S.
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774334672.45
130 rdf:type schema:Person
131 sg:pub.10.1186/1477-7819-6-117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010034034
132 https://doi.org/10.1186/1477-7819-6-117
133 rdf:type schema:CreativeWork
134 https://doi.org/10.1001/archsurg.134.5.487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017701477
135 rdf:type schema:CreativeWork
136 https://doi.org/10.1016/s0960-7404(03)00005-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006064453
137 rdf:type schema:CreativeWork
138 https://doi.org/10.21037/jtd.2016.11.03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068833912
139 rdf:type schema:CreativeWork
140 https://doi.org/10.5732/cjc.014.10048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012675414
141 rdf:type schema:CreativeWork
142 https://www.grid.ac/institutes/grid.17091.3e schema:alternateName University of British Columbia
143 schema:name Division of Infections and Immunolocal Diseases, Department of Pediatrics, University of British Columbia, 317-2194 Health Sciences Mall, BC VT6123, Vacouver, Canada
144 rdf:type schema:Organization
145 https://www.grid.ac/institutes/grid.38142.3c schema:alternateName Harvard University
146 schema:name Department of Molecular and Cell Biology, Harvard University, 7 Divinity Ave., 02138, Cambridge, Massachusetts, USA
147 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...