Sequential proteome alterations during genesis and progression of colon cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-05

AUTHORS

U. J. Roblick, D. Hirschberg, J. K. Habermann, C. Palmberg, S. Becker, S. Krüger, M. Gustafsson, H.-P. Bruch, B. Franzén, T. Ried, T. Bergmann, G. Auer, H. Jörnvall

ABSTRACT

Changes in the proteome of colon mucosal cells accompany the transition from normal mucosa via adenoma and invasive cancer to metastatic disease. Samples from 15 patients with sporadic sigmoid cancers were analyzed. Proteins were separated by two-dimensional gel electrophoresis. Relative differences in expression levels between normal tissue, adenoma, carcinoma and metastasis were evaluated in both intra- and inter-patient comparisons. Up- and down-regulated proteins (> twofold) during development to cancer or metastasis were excised and submitted to peptide mass fingerprinting and MS/MS sequence analysis, facilitated by the use of a compact disc workstation. In total, 112 protein spots were found to be differentially regulated, of which 72 were determined as to protein identity, 46 being up-regulated toward the progression of cancer, and 26 down-regulated. Several of the identifications correlate with proteins of the cell cycle, cytoskeleton or metabolic pathways. The pattern changes now identified have the potential for design of marker panels for assistance in diagnostics and therapeutic strategies in colorectal cancer. More... »

PAGES

1246-1255

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-004-4049-4

DOI

http://dx.doi.org/10.1007/s00018-004-4049-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046423823

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15141310


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Computational Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Progression", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Down-Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Electrophoresis, Gel, Two-Dimensional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mass Spectrometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mucous Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ploidies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Up-Regulation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Oncology and Pathology, Unit of Cancer Proteomics, Karolinska Institutet and Hospital, 171 76, Stockholm, Sweden", 
            "Department of Surgery, Campus L\u00fcbeck Medical School, University of Schleswig-Holstein, L\u00fcbeck, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Roblick", 
        "givenName": "U. J.", 
        "id": "sg:person.0747725223.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747725223.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirschberg", 
        "givenName": "D.", 
        "id": "sg:person.01273107072.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273107072.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Department of Oncology and Pathology, Unit of Cancer Proteomics, Karolinska Institutet and Hospital, 171 76, Stockholm, Sweden", 
            "Department of Genetics Branch, NIH Center for Cancer Research, NCI/NIH, Washington, Bethesda Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Habermann", 
        "givenName": "J. K.", 
        "id": "sg:person.01177570675.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177570675.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Palmberg", 
        "givenName": "C.", 
        "id": "sg:person.01072663641.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072663641.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology and Pathology, Unit of Cancer Proteomics, Karolinska Institutet and Hospital, 171 76, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Becker", 
        "givenName": "S.", 
        "id": "sg:person.013570716017.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013570716017.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of L\u00fcbeck", 
          "id": "https://www.grid.ac/institutes/grid.4562.5", 
          "name": [
            "Institute of Pathology, University of L\u00fcbeck, Medical School, L\u00fcbeck, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kr\u00fcger", 
        "givenName": "S.", 
        "id": "sg:person.01344670267.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344670267.46"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Gyros AB, Uppsala Science Park, 751 83, Uppsala, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gustafsson", 
        "givenName": "M.", 
        "id": "sg:person.01163514170.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163514170.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital Schleswig-Holstein", 
          "id": "https://www.grid.ac/institutes/grid.412468.d", 
          "name": [
            "Department of Surgery, Campus L\u00fcbeck Medical School, University of Schleswig-Holstein, L\u00fcbeck, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bruch", 
        "givenName": "H.-P.", 
        "id": "sg:person.013574305752.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013574305752.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "AstraZeneca (Sweden)", 
          "id": "https://www.grid.ac/institutes/grid.418151.8", 
          "name": [
            "Department of Oncology and Pathology, Unit of Cancer Proteomics, Karolinska Institutet and Hospital, 171 76, Stockholm, Sweden", 
            "Astra Zeneca AB, Preclinical R&D, 151 85, S\u00f6dert\u00e4lje, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Franz\u00e9n", 
        "givenName": "B.", 
        "id": "sg:person.01255225441.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255225441.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.48336.3a", 
          "name": [
            "Department of Genetics Branch, NIH Center for Cancer Research, NCI/NIH, Washington, Bethesda Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ried", 
        "givenName": "T.", 
        "id": "sg:person.01176453675.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176453675.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bergmann", 
        "givenName": "T.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Oncology and Pathology, Unit of Cancer Proteomics, Karolinska Institutet and Hospital, 171 76, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Auer", 
        "givenName": "G.", 
        "id": "sg:person.01314041754.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314041754.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Karolinska Institute", 
          "id": "https://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "J\u00f6rnvall", 
        "givenName": "H.", 
        "id": "sg:person.01211407472.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211407472.30"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1056/nejmoa0706482", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000755110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/eht296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003024186"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.107.763912", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003387490"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.107.743963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003614423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00392-007-0612-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004466153", 
          "https://doi.org/10.1007/s00392-007-0612-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00392-007-0612-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004466153", 
          "https://doi.org/10.1007/s00392-007-0612-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0907272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007455031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1205361", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008862821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(97)07298-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009272162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200002173420702", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011155496"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2012.12559", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012490710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199907083410202", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012874474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehs092", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013182064"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd001800.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015012955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehr213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015413358"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehr236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016275826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1211585", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017413764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coph.2012.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018487135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coph.2012.12.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018487135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1200303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020330063"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehq277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020953814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehq277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020953814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa070829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022199950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2009.07.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022745633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2006.10.074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022755614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa050461", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023665591"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000146338.62813.e7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023903868"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjmed.2008.09.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025545018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.291.3.309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027184649"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)61350-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028469827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0804626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028585181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000121360.31954.1f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030812894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehs215", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030848257"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.110.981407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032885407"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2047487313483610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033627045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/2047487313483610", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033627045"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehi586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034486423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2013.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034769148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.113.000821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037209087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.113.000821", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037209087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0904327", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038668813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehn571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040835067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehq236", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041490808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.295.13.jpc60002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042251036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa0805796", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042261919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa010746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042739677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(10)60168-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043822249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.99.6.779", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044267057"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehi495", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044336263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(08)61172-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044760428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11936-012-0214-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045439565", 
          "https://doi.org/10.1007/s11936-012-0214-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.297.16.1775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047077933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(13)60141-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052553582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehp358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053110331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehp358", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053110331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.260.14.2088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054149145"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4244/eijv4i4a89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072399127"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076798034", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-05", 
    "datePublishedReg": "2004-05-01", 
    "description": "Changes in the proteome of colon mucosal cells accompany the transition from normal mucosa via adenoma and invasive cancer to metastatic disease. Samples from 15 patients with sporadic sigmoid cancers were analyzed. Proteins were separated by two-dimensional gel electrophoresis. Relative differences in expression levels between normal tissue, adenoma, carcinoma and metastasis were evaluated in both intra- and inter-patient comparisons. Up- and down-regulated proteins (> twofold) during development to cancer or metastasis were excised and submitted to peptide mass fingerprinting and MS/MS sequence analysis, facilitated by the use of a compact disc workstation. In total, 112 protein spots were found to be differentially regulated, of which 72 were determined as to protein identity, 46 being up-regulated toward the progression of cancer, and 26 down-regulated. Several of the identifications correlate with proteins of the cell cycle, cytoskeleton or metabolic pathways. The pattern changes now identified have the potential for design of marker panels for assistance in diagnostics and therapeutic strategies in colorectal cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00018-004-4049-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2722560", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1295005", 
        "issn": [
          "1420-682X", 
          "1420-9071"
        ], 
        "name": "Cellular and Molecular Life Sciences", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "10", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "61"
      }
    ], 
    "name": "Sequential proteome alterations during genesis and progression of colon cancer", 
    "pagination": "1246-1255", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "dd246da16676de1614c8ea0fb34e223184d2e6b65c518e5aaf801d62cbd0d0e7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "15141310"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "9705402"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00018-004-4049-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046423823"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00018-004-4049-4", 
      "https://app.dimensions.ai/details/publication/pub.1046423823"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000496.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00018-004-4049-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00018-004-4049-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00018-004-4049-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00018-004-4049-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00018-004-4049-4'


 

This table displays all metadata directly associated to this object as RDF triples.

416 TRIPLES      21 PREDICATES      102 URIs      42 LITERALS      30 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00018-004-4049-4 schema:about N0314dbaa6625471fab4d525649306ec9
2 N13b12abd60b440779a0c0d55bde95105
3 N17ae9f4bae944da9a9510cc75ee50e8b
4 N19e0770b1a8b4ecfb4d4b130a1f0f193
5 N1fe2a6719ec54e4eb79408e2da47fac2
6 N2c31b3db0c964e60b7698912c049e586
7 N44320dd065354d26be4463e3f80bc26b
8 N6313fbb0a2464a8fb1fb73ce19519204
9 N681842135e3448808e637366752885df
10 N7be596b0470041a0af88d497658b30c8
11 N7fed1dfbfad848a2a1169d7af860b689
12 Na57f77a3743943f4925038f4ca67a452
13 Nace4e0721ed8419d985db3a840ad0cba
14 Nbb449c48b78e461e8dbdc1298a124530
15 Nbd65b05ce6ce42f69b8e2ff092f426b4
16 Nc6ea49637abe47c580cbea0a7683245d
17 Ndd41d2da256f4f85a0956d88c271aa76
18 Ne6b0a66d427044f7bff9d758e2fef9ef
19 Ne7b0d6e0a11d4820831a859d985a879a
20 Nf22089fe150043fda35a1061566b6c48
21 Nfa627337a8c54451b29de339b171bda5
22 anzsrc-for:11
23 anzsrc-for:1112
24 schema:author Na000c17f05ce4f41adc5f09b734472b7
25 schema:citation sg:pub.10.1007/s00392-007-0612-y
26 sg:pub.10.1007/s11936-012-0214-5
27 https://app.dimensions.ai/details/publication/pub.1076798034
28 https://doi.org/10.1001/jama.2012.12559
29 https://doi.org/10.1001/jama.260.14.2088
30 https://doi.org/10.1001/jama.291.3.309
31 https://doi.org/10.1001/jama.295.13.jpc60002
32 https://doi.org/10.1001/jama.297.16.1775
33 https://doi.org/10.1002/14651858.cd001800.pub2
34 https://doi.org/10.1016/j.amjmed.2008.09.043
35 https://doi.org/10.1016/j.coph.2012.12.008
36 https://doi.org/10.1016/j.jacc.2006.10.074
37 https://doi.org/10.1016/j.jacc.2009.07.022
38 https://doi.org/10.1016/j.jacc.2013.02.011
39 https://doi.org/10.1016/s0140-6736(08)61172-1
40 https://doi.org/10.1016/s0140-6736(10)60168-7
41 https://doi.org/10.1016/s0140-6736(10)61350-5
42 https://doi.org/10.1016/s0140-6736(13)60141-5
43 https://doi.org/10.1016/s0140-6736(97)07298-x
44 https://doi.org/10.1056/nejm199907083410202
45 https://doi.org/10.1056/nejm200002173420702
46 https://doi.org/10.1056/nejmoa010746
47 https://doi.org/10.1056/nejmoa050461
48 https://doi.org/10.1056/nejmoa0706482
49 https://doi.org/10.1056/nejmoa070829
50 https://doi.org/10.1056/nejmoa0804626
51 https://doi.org/10.1056/nejmoa0805796
52 https://doi.org/10.1056/nejmoa0904327
53 https://doi.org/10.1056/nejmoa0907272
54 https://doi.org/10.1056/nejmoa1200303
55 https://doi.org/10.1056/nejmoa1205361
56 https://doi.org/10.1056/nejmoa1211585
57 https://doi.org/10.1093/eurheartj/ehi495
58 https://doi.org/10.1093/eurheartj/ehi586
59 https://doi.org/10.1093/eurheartj/ehn571
60 https://doi.org/10.1093/eurheartj/ehp358
61 https://doi.org/10.1093/eurheartj/ehq236
62 https://doi.org/10.1093/eurheartj/ehq277
63 https://doi.org/10.1093/eurheartj/ehr213
64 https://doi.org/10.1093/eurheartj/ehr236
65 https://doi.org/10.1093/eurheartj/ehs092
66 https://doi.org/10.1093/eurheartj/ehs215
67 https://doi.org/10.1093/eurheartj/eht296
68 https://doi.org/10.1161/01.cir.0000121360.31954.1f
69 https://doi.org/10.1161/01.cir.0000146338.62813.e7
70 https://doi.org/10.1161/01.cir.99.6.779
71 https://doi.org/10.1161/circulationaha.107.743963
72 https://doi.org/10.1161/circulationaha.107.763912
73 https://doi.org/10.1161/circulationaha.110.981407
74 https://doi.org/10.1161/circulationaha.113.000821
75 https://doi.org/10.1177/2047487313483610
76 https://doi.org/10.4244/eijv4i4a89
77 schema:datePublished 2004-05
78 schema:datePublishedReg 2004-05-01
79 schema:description Changes in the proteome of colon mucosal cells accompany the transition from normal mucosa via adenoma and invasive cancer to metastatic disease. Samples from 15 patients with sporadic sigmoid cancers were analyzed. Proteins were separated by two-dimensional gel electrophoresis. Relative differences in expression levels between normal tissue, adenoma, carcinoma and metastasis were evaluated in both intra- and inter-patient comparisons. Up- and down-regulated proteins (> twofold) during development to cancer or metastasis were excised and submitted to peptide mass fingerprinting and MS/MS sequence analysis, facilitated by the use of a compact disc workstation. In total, 112 protein spots were found to be differentially regulated, of which 72 were determined as to protein identity, 46 being up-regulated toward the progression of cancer, and 26 down-regulated. Several of the identifications correlate with proteins of the cell cycle, cytoskeleton or metabolic pathways. The pattern changes now identified have the potential for design of marker panels for assistance in diagnostics and therapeutic strategies in colorectal cancer.
80 schema:genre research_article
81 schema:inLanguage en
82 schema:isAccessibleForFree false
83 schema:isPartOf N0d822e07f7ed45618df86c112e26ede6
84 N216195e33e1b41d59fd17f1608165050
85 sg:journal.1295005
86 schema:name Sequential proteome alterations during genesis and progression of colon cancer
87 schema:pagination 1246-1255
88 schema:productId N3304d1901207443f8fde9deb3fb835e6
89 N626485d791a94e8a8fa97c4a2fbc3a55
90 Nb41e4720e54f42079bab30f45a325cc0
91 Ncc44429775f34062b10c2f05cd0a412d
92 Nfa7cde47c5714ea486e70cebbdbcb0e1
93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046423823
94 https://doi.org/10.1007/s00018-004-4049-4
95 schema:sdDatePublished 2019-04-10T21:33
96 schema:sdLicense https://scigraph.springernature.com/explorer/license/
97 schema:sdPublisher N5cdb435dcb8941fe9c8f4902344cdd3d
98 schema:url http://link.springer.com/10.1007/s00018-004-4049-4
99 sgo:license sg:explorer/license/
100 sgo:sdDataset articles
101 rdf:type schema:ScholarlyArticle
102 N0314dbaa6625471fab4d525649306ec9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Ploidies
104 rdf:type schema:DefinedTerm
105 N0d822e07f7ed45618df86c112e26ede6 schema:volumeNumber 61
106 rdf:type schema:PublicationVolume
107 N13b12abd60b440779a0c0d55bde95105 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Mass Spectrometry
109 rdf:type schema:DefinedTerm
110 N1515664cae1a4b0f90413b05e42ec314 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
111 schema:familyName Bergmann
112 schema:givenName T.
113 rdf:type schema:Person
114 N1711cd0b8c5c4cb88709529807a9172b rdf:first sg:person.01314041754.28
115 rdf:rest Nbc9f425aacd04cd4a197a90da568fdc5
116 N17ae9f4bae944da9a9510cc75ee50e8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Neoplasm Metastasis
118 rdf:type schema:DefinedTerm
119 N19e0770b1a8b4ecfb4d4b130a1f0f193 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Disease Progression
121 rdf:type schema:DefinedTerm
122 N1fe2a6719ec54e4eb79408e2da47fac2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Adenoma
124 rdf:type schema:DefinedTerm
125 N20946d57269444568e73c6cb153412ad rdf:first sg:person.01273107072.01
126 rdf:rest N6f4defad75984e35b303c086fe4d5b06
127 N216195e33e1b41d59fd17f1608165050 schema:issueNumber 10
128 rdf:type schema:PublicationIssue
129 N21e59c8166954c5eb8ec540d14f3c548 rdf:first sg:person.01344670267.46
130 rdf:rest Nc80ea8e8cddc40de8efbd434e4948457
131 N26fcd44468a74ddebb3836294298db15 schema:name Gyros AB, Uppsala Science Park, 751 83, Uppsala, Sweden
132 rdf:type schema:Organization
133 N271a83d112224c769292ccbb02a690a6 rdf:first N1515664cae1a4b0f90413b05e42ec314
134 rdf:rest N1711cd0b8c5c4cb88709529807a9172b
135 N2c31b3db0c964e60b7698912c049e586 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Mucous Membrane
137 rdf:type schema:DefinedTerm
138 N3304d1901207443f8fde9deb3fb835e6 schema:name nlm_unique_id
139 schema:value 9705402
140 rdf:type schema:PropertyValue
141 N44320dd065354d26be4463e3f80bc26b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Colonic Neoplasms
143 rdf:type schema:DefinedTerm
144 N4ac0bbcb354c4228970d772d04769f4d rdf:first sg:person.013574305752.56
145 rdf:rest N54ce61fc2aab496883df5c132177531e
146 N54ce61fc2aab496883df5c132177531e rdf:first sg:person.01255225441.66
147 rdf:rest N84dbfdf1c7094eb0a1bfa9eeb7f1483e
148 N5cdb435dcb8941fe9c8f4902344cdd3d schema:name Springer Nature - SN SciGraph project
149 rdf:type schema:Organization
150 N626485d791a94e8a8fa97c4a2fbc3a55 schema:name dimensions_id
151 schema:value pub.1046423823
152 rdf:type schema:PropertyValue
153 N6313fbb0a2464a8fb1fb73ce19519204 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Aged, 80 and over
155 rdf:type schema:DefinedTerm
156 N665c9551834a41e497bab9870637bdf7 schema:name Department of Oncology and Pathology, Unit of Cancer Proteomics, Karolinska Institutet and Hospital, 171 76, Stockholm, Sweden
157 rdf:type schema:Organization
158 N681842135e3448808e637366752885df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Peptides
160 rdf:type schema:DefinedTerm
161 N6f4defad75984e35b303c086fe4d5b06 rdf:first sg:person.01177570675.49
162 rdf:rest Ncbdccfc2b8534be3a6cd1db793b8bbb4
163 N7be596b0470041a0af88d497658b30c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Computational Biology
165 rdf:type schema:DefinedTerm
166 N7fed1dfbfad848a2a1169d7af860b689 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Proteome
168 rdf:type schema:DefinedTerm
169 N84dbfdf1c7094eb0a1bfa9eeb7f1483e rdf:first sg:person.01176453675.98
170 rdf:rest N271a83d112224c769292ccbb02a690a6
171 N9bb711f21a4c48f18abc9fbed7605680 schema:name Department of Oncology and Pathology, Unit of Cancer Proteomics, Karolinska Institutet and Hospital, 171 76, Stockholm, Sweden
172 rdf:type schema:Organization
173 Na000c17f05ce4f41adc5f09b734472b7 rdf:first sg:person.0747725223.90
174 rdf:rest N20946d57269444568e73c6cb153412ad
175 Na57f77a3743943f4925038f4ca67a452 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Up-Regulation
177 rdf:type schema:DefinedTerm
178 Nace4e0721ed8419d985db3a840ad0cba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Carcinoma
180 rdf:type schema:DefinedTerm
181 Nb41e4720e54f42079bab30f45a325cc0 schema:name doi
182 schema:value 10.1007/s00018-004-4049-4
183 rdf:type schema:PropertyValue
184 Nbb449c48b78e461e8dbdc1298a124530 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Cell Nucleus
186 rdf:type schema:DefinedTerm
187 Nbc9f425aacd04cd4a197a90da568fdc5 rdf:first sg:person.01211407472.30
188 rdf:rest rdf:nil
189 Nbd65b05ce6ce42f69b8e2ff092f426b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Male
191 rdf:type schema:DefinedTerm
192 Nc6ea49637abe47c580cbea0a7683245d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
193 schema:name Electrophoresis, Gel, Two-Dimensional
194 rdf:type schema:DefinedTerm
195 Nc80ea8e8cddc40de8efbd434e4948457 rdf:first sg:person.01163514170.63
196 rdf:rest N4ac0bbcb354c4228970d772d04769f4d
197 Ncbdccfc2b8534be3a6cd1db793b8bbb4 rdf:first sg:person.01072663641.50
198 rdf:rest Nd91b68e61d88469bbe7f3c10e4aacbc7
199 Ncc44429775f34062b10c2f05cd0a412d schema:name pubmed_id
200 schema:value 15141310
201 rdf:type schema:PropertyValue
202 Nd91b68e61d88469bbe7f3c10e4aacbc7 rdf:first sg:person.013570716017.26
203 rdf:rest N21e59c8166954c5eb8ec540d14f3c548
204 Ndd41d2da256f4f85a0956d88c271aa76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Humans
206 rdf:type schema:DefinedTerm
207 Ne6b0a66d427044f7bff9d758e2fef9ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Down-Regulation
209 rdf:type schema:DefinedTerm
210 Ne7b0d6e0a11d4820831a859d985a879a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Female
212 rdf:type schema:DefinedTerm
213 Nf22089fe150043fda35a1061566b6c48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Middle Aged
215 rdf:type schema:DefinedTerm
216 Nfa627337a8c54451b29de339b171bda5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
217 schema:name Aged
218 rdf:type schema:DefinedTerm
219 Nfa7cde47c5714ea486e70cebbdbcb0e1 schema:name readcube_id
220 schema:value dd246da16676de1614c8ea0fb34e223184d2e6b65c518e5aaf801d62cbd0d0e7
221 rdf:type schema:PropertyValue
222 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
223 schema:name Medical and Health Sciences
224 rdf:type schema:DefinedTerm
225 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
226 schema:name Oncology and Carcinogenesis
227 rdf:type schema:DefinedTerm
228 sg:grant.2722560 http://pending.schema.org/fundedItem sg:pub.10.1007/s00018-004-4049-4
229 rdf:type schema:MonetaryGrant
230 sg:journal.1295005 schema:issn 1420-682X
231 1420-9071
232 schema:name Cellular and Molecular Life Sciences
233 rdf:type schema:Periodical
234 sg:person.01072663641.50 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
235 schema:familyName Palmberg
236 schema:givenName C.
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01072663641.50
238 rdf:type schema:Person
239 sg:person.01163514170.63 schema:affiliation N26fcd44468a74ddebb3836294298db15
240 schema:familyName Gustafsson
241 schema:givenName M.
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163514170.63
243 rdf:type schema:Person
244 sg:person.01176453675.98 schema:affiliation https://www.grid.ac/institutes/grid.48336.3a
245 schema:familyName Ried
246 schema:givenName T.
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176453675.98
248 rdf:type schema:Person
249 sg:person.01177570675.49 schema:affiliation https://www.grid.ac/institutes/grid.48336.3a
250 schema:familyName Habermann
251 schema:givenName J. K.
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177570675.49
253 rdf:type schema:Person
254 sg:person.01211407472.30 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
255 schema:familyName Jörnvall
256 schema:givenName H.
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211407472.30
258 rdf:type schema:Person
259 sg:person.01255225441.66 schema:affiliation https://www.grid.ac/institutes/grid.418151.8
260 schema:familyName Franzén
261 schema:givenName B.
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255225441.66
263 rdf:type schema:Person
264 sg:person.01273107072.01 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
265 schema:familyName Hirschberg
266 schema:givenName D.
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273107072.01
268 rdf:type schema:Person
269 sg:person.01314041754.28 schema:affiliation N665c9551834a41e497bab9870637bdf7
270 schema:familyName Auer
271 schema:givenName G.
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314041754.28
273 rdf:type schema:Person
274 sg:person.01344670267.46 schema:affiliation https://www.grid.ac/institutes/grid.4562.5
275 schema:familyName Krüger
276 schema:givenName S.
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344670267.46
278 rdf:type schema:Person
279 sg:person.013570716017.26 schema:affiliation N9bb711f21a4c48f18abc9fbed7605680
280 schema:familyName Becker
281 schema:givenName S.
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013570716017.26
283 rdf:type schema:Person
284 sg:person.013574305752.56 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
285 schema:familyName Bruch
286 schema:givenName H.-P.
287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013574305752.56
288 rdf:type schema:Person
289 sg:person.0747725223.90 schema:affiliation https://www.grid.ac/institutes/grid.412468.d
290 schema:familyName Roblick
291 schema:givenName U. J.
292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0747725223.90
293 rdf:type schema:Person
294 sg:pub.10.1007/s00392-007-0612-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1004466153
295 https://doi.org/10.1007/s00392-007-0612-y
296 rdf:type schema:CreativeWork
297 sg:pub.10.1007/s11936-012-0214-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045439565
298 https://doi.org/10.1007/s11936-012-0214-5
299 rdf:type schema:CreativeWork
300 https://app.dimensions.ai/details/publication/pub.1076798034 schema:CreativeWork
301 https://doi.org/10.1001/jama.2012.12559 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012490710
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1001/jama.260.14.2088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054149145
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1001/jama.291.3.309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027184649
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1001/jama.295.13.jpc60002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042251036
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1001/jama.297.16.1775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047077933
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1002/14651858.cd001800.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015012955
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1016/j.amjmed.2008.09.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025545018
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1016/j.coph.2012.12.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018487135
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1016/j.jacc.2006.10.074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022755614
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1016/j.jacc.2009.07.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022745633
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1016/j.jacc.2013.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034769148
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1016/s0140-6736(08)61172-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044760428
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1016/s0140-6736(10)60168-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043822249
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1016/s0140-6736(10)61350-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028469827
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1016/s0140-6736(13)60141-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052553582
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1016/s0140-6736(97)07298-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009272162
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1056/nejm199907083410202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012874474
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1056/nejm200002173420702 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011155496
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1056/nejmoa010746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042739677
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1056/nejmoa050461 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023665591
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1056/nejmoa0706482 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000755110
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1056/nejmoa070829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022199950
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1056/nejmoa0804626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028585181
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1056/nejmoa0805796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042261919
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1056/nejmoa0904327 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038668813
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1056/nejmoa0907272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007455031
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1056/nejmoa1200303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020330063
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1056/nejmoa1205361 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008862821
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1056/nejmoa1211585 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017413764
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1093/eurheartj/ehi495 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044336263
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1093/eurheartj/ehi586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034486423
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1093/eurheartj/ehn571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040835067
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1093/eurheartj/ehp358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053110331
366 rdf:type schema:CreativeWork
367 https://doi.org/10.1093/eurheartj/ehq236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041490808
368 rdf:type schema:CreativeWork
369 https://doi.org/10.1093/eurheartj/ehq277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020953814
370 rdf:type schema:CreativeWork
371 https://doi.org/10.1093/eurheartj/ehr213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015413358
372 rdf:type schema:CreativeWork
373 https://doi.org/10.1093/eurheartj/ehr236 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016275826
374 rdf:type schema:CreativeWork
375 https://doi.org/10.1093/eurheartj/ehs092 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013182064
376 rdf:type schema:CreativeWork
377 https://doi.org/10.1093/eurheartj/ehs215 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030848257
378 rdf:type schema:CreativeWork
379 https://doi.org/10.1093/eurheartj/eht296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003024186
380 rdf:type schema:CreativeWork
381 https://doi.org/10.1161/01.cir.0000121360.31954.1f schema:sameAs https://app.dimensions.ai/details/publication/pub.1030812894
382 rdf:type schema:CreativeWork
383 https://doi.org/10.1161/01.cir.0000146338.62813.e7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023903868
384 rdf:type schema:CreativeWork
385 https://doi.org/10.1161/01.cir.99.6.779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044267057
386 rdf:type schema:CreativeWork
387 https://doi.org/10.1161/circulationaha.107.743963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003614423
388 rdf:type schema:CreativeWork
389 https://doi.org/10.1161/circulationaha.107.763912 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003387490
390 rdf:type schema:CreativeWork
391 https://doi.org/10.1161/circulationaha.110.981407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032885407
392 rdf:type schema:CreativeWork
393 https://doi.org/10.1161/circulationaha.113.000821 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037209087
394 rdf:type schema:CreativeWork
395 https://doi.org/10.1177/2047487313483610 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033627045
396 rdf:type schema:CreativeWork
397 https://doi.org/10.4244/eijv4i4a89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072399127
398 rdf:type schema:CreativeWork
399 https://www.grid.ac/institutes/grid.412468.d schema:alternateName University Hospital Schleswig-Holstein
400 schema:name Department of Oncology and Pathology, Unit of Cancer Proteomics, Karolinska Institutet and Hospital, 171 76, Stockholm, Sweden
401 Department of Surgery, Campus Lübeck Medical School, University of Schleswig-Holstein, Lübeck, Germany
402 rdf:type schema:Organization
403 https://www.grid.ac/institutes/grid.418151.8 schema:alternateName AstraZeneca (Sweden)
404 schema:name Astra Zeneca AB, Preclinical R&D, 151 85, Södertälje, Sweden
405 Department of Oncology and Pathology, Unit of Cancer Proteomics, Karolinska Institutet and Hospital, 171 76, Stockholm, Sweden
406 rdf:type schema:Organization
407 https://www.grid.ac/institutes/grid.4562.5 schema:alternateName University of Lübeck
408 schema:name Institute of Pathology, University of Lübeck, Medical School, Lübeck, Germany
409 rdf:type schema:Organization
410 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
411 schema:name Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77, Stockholm, Sweden
412 rdf:type schema:Organization
413 https://www.grid.ac/institutes/grid.48336.3a schema:alternateName National Cancer Institute
414 schema:name Department of Genetics Branch, NIH Center for Cancer Research, NCI/NIH, Washington, Bethesda Maryland, USA
415 Department of Oncology and Pathology, Unit of Cancer Proteomics, Karolinska Institutet and Hospital, 171 76, Stockholm, Sweden
416 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...