Alternative splicing of Bcl-2-related genes: functional consequences and potential therapeutic applications View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-08

AUTHORS

C. Akgul, D. A. Moulding, S. W. Edwards

ABSTRACT

Apoptosis is a morphologically distinct form of cell death. It is executed and regulated by several groups of proteins. Bcl-2 family proteins are the main regulators of the apoptotic process acting either to inhibit or promote it. More than 20 members of the family have been identified so far and most have two or more isoforms. Alternative splicing is one of the major mechanisms providing proteomic complexity and functional diversification of the Bcl-2 family proteins. Pro- and anti-apoptotic Bcl-2 family members should function in harmony for the regulation of the apoptosis machinery, and their relative levels are critical for cell fate. Any mechanism breaking down this harmony by changing the relative levels of these antagonistic proteins could contribute to many diseases, including cancer and neurodegenerative disorders. Recent studies have shown that manipulation of the alternative splicing mechanisms could provide an opportunity to restore the proper balance of these regulator proteins. This review summarises current knowledge on the alternative splicing products of Bcl-2-related genes and modulation of splicing mechanisms as a potential therapeutic approach. More... »

PAGES

2189-2199

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-004-4001-7

DOI

http://dx.doi.org/10.1007/s00018-004-4001-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051566825

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15338051


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213 schema:name Molecular Haematology and Cancer Biology Unit, Camelia Botnar Laboratories, Institute of Child Health, University College London, 30 Guilford Street, WC1N 1EH, London, United Kingdom
214 rdf:type schema:Organization
 




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