Peroxisome proliferator-activated receptor α target genes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-02

AUTHORS

S. Mandard, M. Müller, S. Kersten

ABSTRACT

Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that belong to the superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic compounds such as long-chain fatty acids and their derivatives on transcription of genes commonly called PPAR target genes. Here we review the involvement of PPARalpha in peroxisomal and mitochondrial fatty acid oxidation, microsomal fatty acid hydroxylation, lipoprotein, bile and amino acid metabolism, glucose homeostasis, biotransformation, inflammation control, hepato-carcinogenesis and other pathways, through a detailed analysis of the different known or putative PPARalpha target genes. More... »

PAGES

393-416

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-003-3216-3

DOI

http://dx.doi.org/10.1007/s00018-003-3216-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047522572

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14999402


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