Inhibition of proliferation by 1-8U in interferon-α-responsive and non-responsive cell lines View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-06

AUTHORS

R. Brem, K. Oraszlan-Szovik, S. Foser, B. Bohrmann, U. Certa

ABSTRACT

Interferon (IFN)-inducible proteins of the 1-8 gene family mediate homotypic adhesion and transduction of antiproliferative signals. Their induction correlates with inhibition of cell growth while they are often repressed in the course of malignant transformation and tumor development. Ras-mediated transformation of mouse mast cells is associated with downregulation of 1-8U expression and interferon-alpha (IFN-alpha) treatment reverts the proliferation rate to normal levels together with induction of 1-8U. Conversely, the antiproliferative responses of IFN-alpha in sensitive human melanoma cells are accompanied by 1-8U induction. Here we provide direct evidence that recombinant expression of 1-8U in human cell lines is sufficient to block cell proliferation. Based on the abundant expression and subcellular localization to the plasma membrane and exosome-like structures, we propose a model capable of explaining the pleiotropic functions of 1-8 family proteins in tumor cells and during normal development. More... »

PAGES

1235-1248

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-003-3016-9

DOI

http://dx.doi.org/10.1007/s00018-003-3016-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050817341

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12861389


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172 Roche Center for Medical Genomics (RCMG), F. Hoffmann-La Roche, Ltd., Postfach, 4070 Basel (Switzerland), Fax +41 61 688 14 48, e-mail: ulrich.certa@roche.com, CH
173 rdf:type schema:Organization
 




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