Human Genome and Diseases:¶Double-strand breaks and translocations in cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2002-02

AUTHORS

B. Elliott, M. Jasin

ABSTRACT

The correct repair of double-strand breaks (DSBs) is essential for the genomic integrity of a cell, as inappropriate repair can lead to chromosomal rearrangements such as translocations. In many hematologic cancers and sarcomas, translocations are the etiological factor in tumorigenesis, resulting in either the deregulation of a proto-oncogene or the expression of a fusion protein with transforming properties. Mammalian cells are able to repair DSBs by pathways involving homologous recombination and nonhomologous end-joining. The analysis of translocation breakpoints in a number of cancers and the development of model translocation systems are beginning to shed light on specific DSB repair pathway(s) responsible for the improper repair of broken chromosomes. More... »

PAGES

373-385

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00018-002-8429-3

DOI

http://dx.doi.org/10.1007/s00018-002-8429-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041730580

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11915950


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