Heme oxygenase-1 protects against endotoxin-induced acute lung injury depends on NAD+-mediated mitonuclear communication through PGC1α/PPARγ signaling pathway View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-07-11

AUTHORS

Simeng He, Jia Shi, Wenming Liu, Shihan Du, Yuan Zhang, Lirong Gong, Shuan Dong, Xiangyun Li, Qiaoying Gao, Jing Yang, Jianbo Yu

ABSTRACT

Endotoxin-induced acute lung injury (ALI) is a challenging life-threatening disease for which no specific therapy exists. Mitochondrial dysfunction is corroborated as hallmarks in sepsis which commonly disrupt mitochondria-centered cellular communication networks, especially mitonuclear crosstalk, where the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD+) is essential for mitonuclear communication. Heme oxygenase-1 (HO-1) is critical for maintaining mitochondrial dynamic equilibrium and regulating endoplasmic reticulum (ER) and Golgi stress to alleviating acute lung injury. However, it is unclear whether HO-1 regulates NAD+-mediated mitonuclear communication to exert the endogenous protection during endotoxin-induced ALI. In this study, we observed HO-1 attenuated endotoxin-induced ALI by regulated NAD+ levels and NAD+ affected the mitonuclear communication, including mitonuclear protein imbalance and UPRmt to alleviate lung damage. We also found the protective effect of HO-1 depended on NAD+ and NAD+-mediated mitonuclear communication. Furtherly, the inhibition of the PGC1α/PPARγ signaling exacerbates the septic lung injury by reducing NAD+ levels and repressing the mitonuclear protein imbalance and UPRmt. Altogether, our study certified that HO-1 ameliorated endotoxin-induced acute lung injury by regulating NAD+ and NAD+-mediated mitonuclear communications through PGC1α/PPARγ pathway. The present study provided complementary evidence for the cytoprotective effect of HO-1 as a potential target for preventing and attenuating of endotoxin-induced ALI. More... »

PAGES

1095-1108

References to SciGraph publications

  • 2013-05-22. Mitonuclear protein imbalance as a conserved longevity mechanism in NATURE
  • 2017-04-24. The immunopathology of sepsis and potential therapeutic targets in NATURE REVIEWS IMMUNOLOGY
  • 2020-04-09. COVID-19: immunopathology and its implications for therapy in NATURE REVIEWS IMMUNOLOGY
  • 2020-06-11. Overexpression of Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α Protects Cardiomyocytes from Lipopolysaccharide-Induced Mitochondrial Damage and Apoptosis in INFLAMMATION
  • 2014-09-28. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection in NATURE
  • 2019-02-21. Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure in JOURNAL OF MOLECULAR MEDICINE
  • 2016-03-16. PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection in NATURE
  • 2006-10-06. NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity in THE AAPS JOURNAL
  • 2015-07-17. Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1 in NATURE COMMUNICATIONS
  • 2018-02-09. UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication in CELL RESEARCH
  • 2016-08-18. It takes two to tango: NAD+ and sirtuins in aging/longevity control in NPJ AGING
  • 2019-09-30. PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury in LABORATORY INVESTIGATION
  • 2019-11-21. LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p in CANCER CELL INTERNATIONAL
  • 2021-02-08. MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway in JOURNAL OF INFLAMMATION
  • 2016-03-09. Mitonuclear communication in homeostasis and stress in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00011-022-01605-y

    DOI

    http://dx.doi.org/10.1007/s00011-022-01605-y

    DIMENSIONS

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    PUBMED

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    29 schema:description Endotoxin-induced acute lung injury (ALI) is a challenging life-threatening disease for which no specific therapy exists. Mitochondrial dysfunction is corroborated as hallmarks in sepsis which commonly disrupt mitochondria-centered cellular communication networks, especially mitonuclear crosstalk, where the ubiquitous cofactor nicotinamide adenine dinucleotide (NAD+) is essential for mitonuclear communication. Heme oxygenase-1 (HO-1) is critical for maintaining mitochondrial dynamic equilibrium and regulating endoplasmic reticulum (ER) and Golgi stress to alleviating acute lung injury. However, it is unclear whether HO-1 regulates NAD+-mediated mitonuclear communication to exert the endogenous protection during endotoxin-induced ALI. In this study, we observed HO-1 attenuated endotoxin-induced ALI by regulated NAD+ levels and NAD+ affected the mitonuclear communication, including mitonuclear protein imbalance and UPRmt to alleviate lung damage. We also found the protective effect of HO-1 depended on NAD+ and NAD+-mediated mitonuclear communication. Furtherly, the inhibition of the PGC1α/PPARγ signaling exacerbates the septic lung injury by reducing NAD+ levels and repressing the mitonuclear protein imbalance and UPRmt. Altogether, our study certified that HO-1 ameliorated endotoxin-induced acute lung injury by regulating NAD+ and NAD+-mediated mitonuclear communications through PGC1α/PPARγ pathway. The present study provided complementary evidence for the cytoprotective effect of HO-1 as a potential target for preventing and attenuating of endotoxin-induced ALI.
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