Could different aqueous humor and plasma cytokine profiles help differentiate between ocular sarcoidosis and ocular tuberculosis? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-06-28

AUTHORS

L. De Simone, M. Bonacini, R. Aldigeri, F. Alessandrello, V. Mastrofilippo, F. Gozzi, E. Bolletta, C. Adani, A. Zerbini, G. M. Cavallini, L. Fontana, C. Salvarani, S. Croci, L. Cimino

ABSTRACT

Objective and designA cross-sectional single-center study was conducted to assess cytokine levels in aqueous humor (AH) and plasma of three different uveitis entities: definite ocular sarcoidosis (OS), definite OS associated with QuantiFERON®-TB Gold test positivity (Q + OS) and presumed tubercular uveitis (TBU).SubjectsThirty-two patients (15 OS, 5 Q + OS, 12 TBU) were included.MethodsQuantification of selected cytokines was performed on blood and AH samples collected before starting any treatment. Statistical analysis was conducted using the Kruskal–Wallis test, the Mann–Whitney or Fisher test and the Principal Component Analysis (PCA).ResultsIL-6, IL-8 and IP-10 levels were higher in AH samples than in peripheral blood. In AH samples, BLC, IL-8 and IP-10 were significantly higher in definite OS than in presumptive TBU. There were no statistically significant differences in terms of cytokine levels between Q + OS and presumptive TBU. PCA showed a similar cytokine pattern in the latter two groups (IFNγ, IL-15, IL-2, IP-10, MIG), while the prevalent expression of BLC, IL-10 and MIP-3 α was seen in definite OS.ConclusionsThe different AH and plasma cytokine profiles observed in OS compared to Q + OS and TBU may help to differentiate OS from TBU in overlapping clinical phenotypes of granulomatous uveitis (Q + OS). More... »

PAGES

949-961

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00011-022-01601-2

DOI

http://dx.doi.org/10.1007/s00011-022-01601-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1149025582

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35763079


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20 schema:description Objective and designA cross-sectional single-center study was conducted to assess cytokine levels in aqueous humor (AH) and plasma of three different uveitis entities: definite ocular sarcoidosis (OS), definite OS associated with QuantiFERON®-TB Gold test positivity (Q + OS) and presumed tubercular uveitis (TBU).SubjectsThirty-two patients (15 OS, 5 Q + OS, 12 TBU) were included.MethodsQuantification of selected cytokines was performed on blood and AH samples collected before starting any treatment. Statistical analysis was conducted using the Kruskal–Wallis test, the Mann–Whitney or Fisher test and the Principal Component Analysis (PCA).ResultsIL-6, IL-8 and IP-10 levels were higher in AH samples than in peripheral blood. In AH samples, BLC, IL-8 and IP-10 were significantly higher in definite OS than in presumptive TBU. There were no statistically significant differences in terms of cytokine levels between Q + OS and presumptive TBU. PCA showed a similar cytokine pattern in the latter two groups (IFNγ, IL-15, IL-2, IP-10, MIG), while the prevalent expression of BLC, IL-10 and MIP-3 α was seen in definite OS.ConclusionsThe different AH and plasma cytokine profiles observed in OS compared to Q + OS and TBU may help to differentiate OS from TBU in overlapping clinical phenotypes of granulomatous uveitis (Q + OS).
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55 objective
56 ocular sarcoidosis
57 ocular tuberculosis
58 patients
59 patterns
60 peripheral blood
61 phenotype
62 plasma
63 plasma cytokine profiles
64 positivity
65 prevalent expression
66 principal component analysis
67 profile
68 samples
69 sarcoidosis
70 significant differences
71 similar cytokine pattern
72 single-center study
73 statistical analysis
74 study
75 terms
76 test
77 test positivity
78 treatment
79 tubercular uveitis
80 tuberculosis
81 uveitis
82 uveitis entities
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