Particulate matter in COPD pathogenesis: an overview View Full Text


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Article Info

DATE

2022-06-16

AUTHORS

Manpreet Kaur, Jitender Chandel, Jai Malik, Amarjit S. Naura

ABSTRACT

Chronic obstructive pulmonary disease (COPD) is a progressive lung disorder with substantial patient burden and leading cause of death globally. Cigarette smoke remains to be the most recognised causative factor behind COPD pathogenesis. Given the alarming increase in prevalence of COPD amongst non-smokers in recent past, a potential role of air pollution particularly particulate matter (PM) in COPD development has gained much attention of the scientists. Indeed, several epidemiological studies indicate strong correlation between airborne PM and COPD incidence/exacerbations. PM-induced oxidative stress seems to be the major player in orchestrating COPD inflammatory cycle but the exact molecular mechanism(s) behind such a process are still poorly understood. This may be due to the complexity of multiple molecular pathways involved. Oxidative stress-linked mitochondrial dysfunction and autophagy have also gained importance and have been the focus of recent studies regarding COPD pathogenesis. Accordingly, the present review is aimed at understanding the key molecular players behind PM-mediated COPD pathogenesis through analysis of various experimental studies supported by epidemiological data to identify relevant preventive/therapeutic targets in the area. More... »

PAGES

797-815

References to SciGraph publications

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  • 2015-10-12. Metabolic changes of H2S in smokers and patients of COPD which might involve in inflammation, oxidative stress and steroid sensitivity in SCIENTIFIC REPORTS
  • 2017-03-09. The acute airway inflammation induced by PM2.5 exposure and the treatment of essential oils in Balb/c mice in SCIENTIFIC REPORTS
  • 2019-06-13. Role of PM2.5 in the development and progression of COPD and its mechanisms in RESPIRATORY RESEARCH
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  • 2012-07-22. Fine PM induce airway MUC5AC expression through the autocrine effect of amphiregulin in ARCHIVES OF TOXICOLOGY
  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00011-022-01594-y

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