Stadienorientierte Antibiotikatherapie der Peritonitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1997-07

AUTHORS

G. J. Winkeltau, C. Töns, P. Bertram, V. Schumpelick

ABSTRACT

Patients and methods: In a prospective protocol 25 consecutive patients with diffuse peritonitis were treated in the Surgical Clinic of the RWT-University in Aachen, Germany, from January to December 1995. According to the ``Mannheim Peritonitis Score'' three different stages were treated with different surgical procedures and a selective antibiotic regimen. Group-A patients with prognostically favorable peritonitis (MPS 0–20) were treated with the so-called standard procedure, group-B patients (MPS: 21–29) with closed postoperative lavage. The antibiotic regimen was cefotaxime (2×2 g) and metronidazole (2×500 mg) for both group-A and group-B patients. Severe group-C cases (MPS >29) were treated with the so-called Etappenlavage (multiple reexplorations and intraoperative lavage) and received a combination of three antibiotics (2×2 g cefotaxime; 2×500 mg metronidazole and 2×200 mg ofloxacin). Results: Eight patients belonged to group A, 10 to group B, and 7 to group C. The mortality was 0% (group A), 20% (group B), and 29% (group C), respectively. The actual overall mortality of the whole group was 16% (4/25). The statistically expected mortality was 36%, according to the APACHE-II-Score (P=0.0982). More... »

PAGES

s22-s25

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/pl00014639

DOI

http://dx.doi.org/10.1007/pl00014639

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037489215

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9333703


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