Allelic loss of the NF1 gene in anal malignant melanoma in a patient with neurofibromatosis type 1 View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-08

AUTHORS

S. Ishii, S. Han, K. Shiiba, T. Mizoi, M. Okabe, A. Horii, H. Nagura, S. Matsuno, I. Sasaki

ABSTRACT

A 64-year-old man with neurofibromatosis type 1 (NF1) developed a primary malignant melanoma of the anus. Genetic analysis of the resected tumor confirmed loss of heterozygosity (LOH) of the NF1 gene. Anorectal malignant melanoma in NF1 is extremely rare, and genetic studies of the NF1 gene in such patients have not been reported. The allelic loss detected in the present patient supports the previously raised idea that NF1 can function as a tumor suppressor gene in the development of malignant melanoma in patients with NF1. More... »

PAGES

201-204

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/pl00012105

DOI

http://dx.doi.org/10.1007/pl00012105

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034909125

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11706558


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