Relationship between interleukin-1-alpha concentration in tumors and cell growth in gastric cancer, determined using flow cytometry View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2000-09

AUTHORS

Yoshitaka Furuya, Takashi Ichikura, Hidetaka Mochizuki, Nariyoshi Shinomiya

ABSTRACT

Background. Interleukin-1-alpha (IL-1α) produced by tumor cells stimulates the proliferation or the growth of several cancer cell lines. The aim of this study was to clarify the relationship between growth activity evaluated by DNA analysis and the concentration of tumor-derived IL-1α in gastric cancers in clinical cases.Methods. We measured the concentration of IL-1α in homogenized tumor samples obtained from 49 patients with gastric cancer, using an enzyme-linked immunosorbent assay, and we analyzed the cellular DNA content of paraffin-embedded tumor sections using flow cytometry.Results. Both the IL-1α concentration and the percentage of S-phase fraction were significantly correlated with liver metastasis, histologic type, pattern of tumor infiltration, quantity of stroma, and venous invasion. A good correlation was found between IL-1α concentration in tumors and the percentage of S-phase fraction (R = 0.604, P < 0.0001).Conclusion. IL-1α may be related to the stimulation of cell growth of gastric cancer in clinical cases. More... »

PAGES

86-90

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/pl00011701

DOI

http://dx.doi.org/10.1007/pl00011701

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006551627

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11984716


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