The molecular basis of persistent hyperinsulinemic hypoglycemia of infancy and its pathologic substrates View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-01

AUTHORS

A. Reinecke-Lüthge, F. Koschoreck, G. Klöppel

ABSTRACT

Recent advances in molecular genetics have established a molecular basis for persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and resulted in the identification of a number of well-defined genetic defects. On the basis of the available information on the molecular changes so far described, an attempt has been made to classify PHHI patients according to their genotype and phenotype, with reference to molecular genetics, pancreatic pathology and clinical appearance. This classification has resulted in the differentiation of three groups of PHHI patients, two with diffuse beta cell hyperfunction and one with focal beta cell hyperfunction. More... »

PAGES

1-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/pl00008192

DOI

http://dx.doi.org/10.1007/pl00008192

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1010204496

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10664155


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperinsulinism", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoglycemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Infant, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Islets of Langerhans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatic Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenotype", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Kiel, Michaelisstrasse 11, D-24105 Kiel, Germany, DE", 
          "id": "http://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Department of Pathology, University of Kiel, Michaelisstrasse 11, D-24105 Kiel, Germany, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Reinecke-L\u00fcthge", 
        "givenName": "A.", 
        "id": "sg:person.01227702145.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227702145.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Kiel, Michaelisstrasse 11, D-24105 Kiel, Germany, DE", 
          "id": "http://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Department of Pathology, University of Kiel, Michaelisstrasse 11, D-24105 Kiel, Germany, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koschoreck", 
        "givenName": "F.", 
        "id": "sg:person.01235646446.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235646446.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, University of Kiel, Michaelisstrasse 11, D-24105 Kiel, Germany, DE", 
          "id": "http://www.grid.ac/institutes/grid.9764.c", 
          "name": [
            "Department of Pathology, University of Kiel, Michaelisstrasse 11, D-24105 Kiel, Germany, DE"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kl\u00f6ppel", 
        "givenName": "G.", 
        "id": "sg:person.016522011357.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016522011357.98"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2000-01", 
    "datePublishedReg": "2000-01-01", 
    "description": "Abstract\u2002Recent advances in molecular genetics have established a molecular basis for persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and resulted in the identification of a number of well-defined genetic defects. On the basis of the available information on the molecular changes so far described, an attempt has been made to classify PHHI patients according to their genotype and phenotype, with reference to molecular genetics, pancreatic pathology and clinical appearance. This classification has resulted in the differentiation of three groups of PHHI patients, two with diffuse beta cell hyperfunction and one with focal beta cell hyperfunction.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/pl00008192", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1106235", 
        "issn": [
          "0945-6317", 
          "1432-2307"
        ], 
        "name": "Virchows Archiv", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "436"
      }
    ], 
    "keywords": [
      "molecular basis", 
      "molecular genetics", 
      "PHHI patients", 
      "persistent hyperinsulinemic hypoglycemia", 
      "genetic defects", 
      "molecular changes", 
      "genetics", 
      "cell hyperfunction", 
      "recent advances", 
      "hyperinsulinemic hypoglycemia", 
      "phenotype", 
      "differentiation", 
      "pathologic substrate", 
      "clinical appearance", 
      "genotypes", 
      "pancreatic pathology", 
      "basis", 
      "available information", 
      "identification", 
      "hypoglycemia", 
      "patients", 
      "substrate", 
      "hyperfunction", 
      "defects", 
      "infancy", 
      "advances", 
      "pathology", 
      "changes", 
      "number", 
      "group", 
      "appearance", 
      "information", 
      "attempt", 
      "classification", 
      "reference", 
      "diffuse beta cell hyperfunction", 
      "beta cell hyperfunction", 
      "focal beta cell hyperfunction"
    ], 
    "name": "The molecular basis of persistent hyperinsulinemic hypoglycemia of infancy and its pathologic substrates", 
    "pagination": "1-5", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1010204496"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/pl00008192"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "10664155"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/pl00008192", 
      "https://app.dimensions.ai/details/publication/pub.1010204496"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_310.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/pl00008192"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/pl00008192'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/pl00008192'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/pl00008192'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/pl00008192'


 

This table displays all metadata directly associated to this object as RDF triples.

158 TRIPLES      21 PREDICATES      76 URIs      68 LITERALS      18 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/pl00008192 schema:about N0261bc521c064884aa6625e8c0098b5e
2 N0617fb10db574b539758311da6c83013
3 N0a5dfed643ec40bf9a10764c709d8122
4 N146371e975514cb4b93b00787f8743bc
5 N7b4e35a0a1764a5ba6051ac07456e42c
6 N93069e45cce84912b12e29884f171f6d
7 N9ab44ab4237c431b94eae6ad9b50c762
8 Nbdd1653e97bb4d63a9c34a22a027e8b5
9 Nd16d893264f64a75a97ca8a64ecbf4fe
10 Ne68b5a2c15cc46dcb3b808d8b3d8dbbc
11 Ne871116b99de49b49fbae5101f82a530
12 anzsrc-for:11
13 anzsrc-for:1103
14 schema:author Ne4941a280e434d78bd63ff77a8b7dcf8
15 schema:datePublished 2000-01
16 schema:datePublishedReg 2000-01-01
17 schema:description Abstract Recent advances in molecular genetics have established a molecular basis for persistent hyperinsulinemic hypoglycemia of infancy (PHHI) and resulted in the identification of a number of well-defined genetic defects. On the basis of the available information on the molecular changes so far described, an attempt has been made to classify PHHI patients according to their genotype and phenotype, with reference to molecular genetics, pancreatic pathology and clinical appearance. This classification has resulted in the differentiation of three groups of PHHI patients, two with diffuse beta cell hyperfunction and one with focal beta cell hyperfunction.
18 schema:genre article
19 schema:inLanguage en
20 schema:isAccessibleForFree false
21 schema:isPartOf N6e3ad27d5ef24cc5a4720063bd1894b8
22 Ndc1f8ed1f2f54e3da2ed3e5cf8c99ba5
23 sg:journal.1106235
24 schema:keywords PHHI patients
25 advances
26 appearance
27 attempt
28 available information
29 basis
30 beta cell hyperfunction
31 cell hyperfunction
32 changes
33 classification
34 clinical appearance
35 defects
36 differentiation
37 diffuse beta cell hyperfunction
38 focal beta cell hyperfunction
39 genetic defects
40 genetics
41 genotypes
42 group
43 hyperfunction
44 hyperinsulinemic hypoglycemia
45 hypoglycemia
46 identification
47 infancy
48 information
49 molecular basis
50 molecular changes
51 molecular genetics
52 number
53 pancreatic pathology
54 pathologic substrate
55 pathology
56 patients
57 persistent hyperinsulinemic hypoglycemia
58 phenotype
59 recent advances
60 reference
61 substrate
62 schema:name The molecular basis of persistent hyperinsulinemic hypoglycemia of infancy and its pathologic substrates
63 schema:pagination 1-5
64 schema:productId N53d5b41d67f44d08acbe3e898339d9d7
65 N904c26e54ccf4931b5a331c3a420f0b9
66 Neae3b239adb1464590b7e264ad5cabf0
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010204496
68 https://doi.org/10.1007/pl00008192
69 schema:sdDatePublished 2022-01-01T18:09
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N588a165f9e48460ab55b54aa9ad071c5
72 schema:url https://doi.org/10.1007/pl00008192
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N0261bc521c064884aa6625e8c0098b5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Infant, Newborn
78 rdf:type schema:DefinedTerm
79 N0617fb10db574b539758311da6c83013 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Phenotype
81 rdf:type schema:DefinedTerm
82 N0a5dfed643ec40bf9a10764c709d8122 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Pancreatic Diseases
84 rdf:type schema:DefinedTerm
85 N146371e975514cb4b93b00787f8743bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Male
87 rdf:type schema:DefinedTerm
88 N3cc8e4e262824f5f85fa54e1d7bb1af1 rdf:first sg:person.016522011357.98
89 rdf:rest rdf:nil
90 N53d5b41d67f44d08acbe3e898339d9d7 schema:name pubmed_id
91 schema:value 10664155
92 rdf:type schema:PropertyValue
93 N588a165f9e48460ab55b54aa9ad071c5 schema:name Springer Nature - SN SciGraph project
94 rdf:type schema:Organization
95 N6e3ad27d5ef24cc5a4720063bd1894b8 schema:issueNumber 1
96 rdf:type schema:PublicationIssue
97 N7b4e35a0a1764a5ba6051ac07456e42c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Hypoglycemia
99 rdf:type schema:DefinedTerm
100 N904c26e54ccf4931b5a331c3a420f0b9 schema:name doi
101 schema:value 10.1007/pl00008192
102 rdf:type schema:PropertyValue
103 N93069e45cce84912b12e29884f171f6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Islets of Langerhans
105 rdf:type schema:DefinedTerm
106 N9ab44ab4237c431b94eae6ad9b50c762 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Hyperinsulinism
108 rdf:type schema:DefinedTerm
109 Nbdd1653e97bb4d63a9c34a22a027e8b5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Infant
111 rdf:type schema:DefinedTerm
112 Nc9d5da28daaa4536900275290f3defd7 rdf:first sg:person.01235646446.48
113 rdf:rest N3cc8e4e262824f5f85fa54e1d7bb1af1
114 Nd16d893264f64a75a97ca8a64ecbf4fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Female
116 rdf:type schema:DefinedTerm
117 Ndc1f8ed1f2f54e3da2ed3e5cf8c99ba5 schema:volumeNumber 436
118 rdf:type schema:PublicationVolume
119 Ne4941a280e434d78bd63ff77a8b7dcf8 rdf:first sg:person.01227702145.22
120 rdf:rest Nc9d5da28daaa4536900275290f3defd7
121 Ne68b5a2c15cc46dcb3b808d8b3d8dbbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Humans
123 rdf:type schema:DefinedTerm
124 Ne871116b99de49b49fbae5101f82a530 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Genotype
126 rdf:type schema:DefinedTerm
127 Neae3b239adb1464590b7e264ad5cabf0 schema:name dimensions_id
128 schema:value pub.1010204496
129 rdf:type schema:PropertyValue
130 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
131 schema:name Medical and Health Sciences
132 rdf:type schema:DefinedTerm
133 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
134 schema:name Clinical Sciences
135 rdf:type schema:DefinedTerm
136 sg:journal.1106235 schema:issn 0945-6317
137 1432-2307
138 schema:name Virchows Archiv
139 schema:publisher Springer Nature
140 rdf:type schema:Periodical
141 sg:person.01227702145.22 schema:affiliation grid-institutes:grid.9764.c
142 schema:familyName Reinecke-Lüthge
143 schema:givenName A.
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01227702145.22
145 rdf:type schema:Person
146 sg:person.01235646446.48 schema:affiliation grid-institutes:grid.9764.c
147 schema:familyName Koschoreck
148 schema:givenName F.
149 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235646446.48
150 rdf:type schema:Person
151 sg:person.016522011357.98 schema:affiliation grid-institutes:grid.9764.c
152 schema:familyName Klöppel
153 schema:givenName G.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016522011357.98
155 rdf:type schema:Person
156 grid-institutes:grid.9764.c schema:alternateName Department of Pathology, University of Kiel, Michaelisstrasse 11, D-24105 Kiel, Germany, DE
157 schema:name Department of Pathology, University of Kiel, Michaelisstrasse 11, D-24105 Kiel, Germany, DE
158 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...